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Journal Abstract Search

207 related items for PubMed ID: 20392070

  • 1. Synthesis of reblastatin, autolytimycin, and non-benzoquinone analogues: potent inhibitors of heat shock protein 90.
    Wrona IE, Gozman A, Taldone T, Chiosis G, Panek JS.
    J Org Chem; 2010 May 07; 75(9):2820-35. PubMed ID: 20392070
    [Abstract] [Full Text] [Related]

  • 2. Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.
    Ge J, Normant E, Porter JR, Ali JA, Dembski MS, Gao Y, Georges AT, Grenier L, Pak RH, Patterson J, Sydor JR, Tibbitts TT, Tong JK, Adams J, Palombella VJ.
    J Med Chem; 2006 Jul 27; 49(15):4606-15. PubMed ID: 16854066
    [Abstract] [Full Text] [Related]

  • 3. Potent cytotoxic C-11 modified geldanamycin analogues.
    Tian ZQ, Wang Z, MacMillan KS, Zhou Y, Carreras CW, Mueller T, Myles DC, Liu Y.
    J Med Chem; 2009 May 28; 52(10):3265-73. PubMed ID: 19405528
    [Abstract] [Full Text] [Related]

  • 4. Synthesis and biological evaluation of a new class of geldanamycin derivatives as potent inhibitors of Hsp90.
    Le Brazidec JY, Kamal A, Busch D, Thao L, Zhang L, Timony G, Grecko R, Trent K, Lough R, Salazar T, Khan S, Burrows F, Boehm MF.
    J Med Chem; 2004 Jul 15; 47(15):3865-73. PubMed ID: 15239664
    [Abstract] [Full Text] [Related]

  • 5. Total synthesis of the Hsp90 inhibitor geldanamycin.
    Qin HL, Panek JS.
    Org Lett; 2008 Jun 19; 10(12):2477-9. PubMed ID: 18489177
    [Abstract] [Full Text] [Related]

  • 6. Synthetic ansamycins prepared by a ring-expanding Claisen rearrangement. Synthesis and biological evaluation of ring and conformational analogues of the Hsp90 molecular chaperone inhibitor geldanamycin.
    McErlean CS, Proisy N, Davis CJ, Boland NA, Sharp SY, Boxall K, Slawin AM, Workman P, Moody CJ.
    Org Biomol Chem; 2007 Feb 07; 5(3):531-46. PubMed ID: 17252137
    [Abstract] [Full Text] [Related]

  • 7. In vitro and in vivo Evaluation of 17-phenylpropylamine/phenoxyethylamine- 17-demethoxygeldanamycins as Potent Hsp90 Inhibitors.
    Li Z, Jia L, Xu H, Lu C, Shena Y.
    Med Chem; 2015 Feb 07; 11(5):482-8. PubMed ID: 25537129
    [Abstract] [Full Text] [Related]

  • 8. An improved route to 19-substituted geldanamycins as novel Hsp90 inhibitors--potential therapeutics in cancer and neurodegeneration.
    Kitson RR, Moody CJ.
    Chem Commun (Camb); 2013 Oct 04; 49(76):8441-3. PubMed ID: 23770604
    [Abstract] [Full Text] [Related]

  • 9. Design, synthesis and biological evaluation of 17-arylmethylamine-17-demethoxygeldanamycin derivatives as potent Hsp90 inhibitors.
    Li Z, Jia L, Wang J, Wu X, Hao H, Xu H, Wu Y, Shi G, Lu C, Shen Y.
    Eur J Med Chem; 2014 Oct 06; 85():359-70. PubMed ID: 25105924
    [Abstract] [Full Text] [Related]

  • 10. Synthesis and anticancer activity of geldanamycin derivatives derived from biosynthetically generated metabolites.
    Lee K, Ryu JS, Jin Y, Kim W, Kaur N, Chung SJ, Jeon YJ, Park JT, Bang JS, Lee HS, Kim TY, Lee JJ, Hong YS.
    Org Biomol Chem; 2008 Jan 21; 6(2):340-8. PubMed ID: 18175003
    [Abstract] [Full Text] [Related]

  • 11. Discovery of diamine-linked 17-aroylamido-17-demethoxygeldanamycins as potent Hsp90 inhibitors.
    Li Z, Jia L, Wang J, Wu X, Hao H, Wu Y, Xu H, Wang Z, Shi G, Lu C, Shen Y.
    Eur J Med Chem; 2014 Nov 24; 87():346-63. PubMed ID: 25277067
    [Abstract] [Full Text] [Related]

  • 12. Discovery and development of heat shock protein 90 inhibitors as anticancer agents: a review of patented potent geldanamycin derivatives.
    Kim T, Keum G, Pae AN.
    Expert Opin Ther Pat; 2013 Aug 24; 23(8):919-43. PubMed ID: 23641970
    [Abstract] [Full Text] [Related]

  • 13. Learning from nature: advances in geldanamycin- and radicicol-based inhibitors of Hsp90.
    Kitson RR, Moody CJ.
    J Org Chem; 2013 Jun 07; 78(11):5117-41. PubMed ID: 23496136
    [Abstract] [Full Text] [Related]

  • 14. Synthesis and biological activities of novel 17-aminogeldanamycin derivatives.
    Tian ZQ, Liu Y, Zhang D, Wang Z, Dong SD, Carreras CW, Zhou Y, Rastelli G, Santi DV, Myles DC.
    Bioorg Med Chem; 2004 Oct 15; 12(20):5317-29. PubMed ID: 15388159
    [Abstract] [Full Text] [Related]

  • 15. Targeting heat-shock-protein 90 (Hsp90) by natural products: geldanamycin, a show case in cancer therapy.
    Franke J, Eichner S, Zeilinger C, Kirschning A.
    Nat Prod Rep; 2013 Oct 11; 30(10):1299-323. PubMed ID: 23934201
    [Abstract] [Full Text] [Related]

  • 16. Conformational significance of EH21A1-A4, phenolic derivatives of geldanamycin, for Hsp90 inhibitory activity.
    Onodera H, Kaneko M, Takahashi Y, Uochi Y, Funahashi J, Nakashima T, Soga S, Suzuki M, Ikeda S, Yamashita Y, Rahayu ES, Kanda Y, Ichimura M.
    Bioorg Med Chem Lett; 2008 Mar 01; 18(5):1588-91. PubMed ID: 18243703
    [Abstract] [Full Text] [Related]

  • 17. Convergent synthesis and discovery of a natural product-inspired paralog-selective Hsp90 inhibitor.
    Jeso V, Cherry L, Macklin TK, Pan SC, LoGrasso PV, Micalizio GC.
    Org Lett; 2011 Oct 07; 13(19):5108-11. PubMed ID: 21866939
    [Abstract] [Full Text] [Related]

  • 18. Radester, a novel inhibitor of the Hsp90 protein folding machinery.
    Shen G, Blagg BS.
    Org Lett; 2005 May 26; 7(11):2157-60. PubMed ID: 15901158
    [Abstract] [Full Text] [Related]

  • 19. Design of quinolinedione-based geldanamycin analogues.
    Hargreaves R, David CL, Whitesell L, Skibo EB.
    Bioorg Med Chem Lett; 2003 Sep 15; 13(18):3075-8. PubMed ID: 12941337
    [Abstract] [Full Text] [Related]

  • 20. Benzoquinone ansamycin heat shock protein 90 inhibitors modulate multiple functions required for tumor angiogenesis.
    Sanderson S, Valenti M, Gowan S, Patterson L, Ahmad Z, Workman P, Eccles SA.
    Mol Cancer Ther; 2006 Mar 15; 5(3):522-32. PubMed ID: 16546966
    [Abstract] [Full Text] [Related]

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