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181 related items for PubMed ID: 20404324

  • 1. Catalytic mechanism of heparinase II investigated by site-directed mutagenesis and the crystal structure with its substrate.
    Shaya D, Zhao W, Garron ML, Xiao Z, Cui Q, Zhang Z, Sulea T, Linhardt RJ, Cygler M.
    J Biol Chem; 2010 Jun 25; 285(26):20051-61. PubMed ID: 20404324
    [Abstract] [Full Text] [Related]

  • 2. Crystal structure of heparinase II from Pedobacter heparinus and its complex with a disaccharide product.
    Shaya D, Tocilj A, Li Y, Myette J, Venkataraman G, Sasisekharan R, Cygler M.
    J Biol Chem; 2006 Jun 02; 281(22):15525-35. PubMed ID: 16565082
    [Abstract] [Full Text] [Related]

  • 3. Characterization of chondroitin sulfate lyase ABC from Bacteroides thetaiotaomicron WAL2926.
    Shaya D, Hahn BS, Park NY, Sim JS, Kim YS, Cygler M.
    Biochemistry; 2008 Jun 24; 47(25):6650-61. PubMed ID: 18512954
    [Abstract] [Full Text] [Related]

  • 4. Isolation of the porcine heparin tetrasaccharides with glucuronate 2-O-sulfate. Heparinase cleaves glucuronate 2-O-sulfate-containing disaccharides in highly sulfated blocks in heparin.
    Yamada S, Murakami T, Tsuda H, Yoshida K, Sugahara K.
    J Biol Chem; 1995 Apr 14; 270(15):8696-705. PubMed ID: 7721774
    [Abstract] [Full Text] [Related]

  • 5. Heparinase I from Flavobacterium heparinum. Identification of a critical histidine residue essential for catalysis as probed by chemical modification and site-directed mutagenesis.
    Godavarti R, Cooney CL, Langer R, Sasisekharan R.
    Biochemistry; 1996 May 28; 35(21):6846-52. PubMed ID: 8639636
    [Abstract] [Full Text] [Related]

  • 6. Heparinase II from Flavobacterium heparinum. Role of histidine residues in enzymatic activity as probed by chemical modification and site-directed mutagenesis.
    Shriver Z, Hu Y, Sasisekharan R.
    J Biol Chem; 1998 Apr 24; 273(17):10160-7. PubMed ID: 9553064
    [Abstract] [Full Text] [Related]

  • 7. The structure of chondroitin B lyase complexed with glycosaminoglycan oligosaccharides unravels a calcium-dependent catalytic machinery.
    Michel G, Pojasek K, Li Y, Sulea T, Linhardt RJ, Raman R, Prabhakar V, Sasisekharan R, Cygler M.
    J Biol Chem; 2004 Jul 30; 279(31):32882-96. PubMed ID: 15155751
    [Abstract] [Full Text] [Related]

  • 8. Examination of the substrate specificity of heparin and heparan sulfate lyases.
    Linhardt RJ, Turnbull JE, Wang HM, Loganathan D, Gallagher JT.
    Biochemistry; 1990 Mar 13; 29(10):2611-7. PubMed ID: 2334685
    [Abstract] [Full Text] [Related]

  • 9. Expanding the Catalytic Promiscuity of Heparinase III from Pedobacter heparinus.
    Gu Y, Lu M, Wang Z, Wu X, Chen Y.
    Chemistry; 2017 Feb 21; 23(11):2548-2551. PubMed ID: 28067452
    [Abstract] [Full Text] [Related]

  • 10. Crystal structure of a bacterial unsaturated glucuronyl hydrolase with specificity for heparin.
    Nakamichi Y, Mikami B, Murata K, Hashimoto W.
    J Biol Chem; 2014 Feb 21; 289(8):4787-97. PubMed ID: 24403065
    [Abstract] [Full Text] [Related]

  • 11. Histidine 295 and histidine 510 are crucial for the enzymatic degradation of heparan sulfate by heparinase III.
    Pojasek K, Shriver Z, Hu Y, Sasisekharan R.
    Biochemistry; 2000 Apr 11; 39(14):4012-9. PubMed ID: 10747789
    [Abstract] [Full Text] [Related]

  • 12. Heparinase II from Flavobacterium heparinum. Role of cysteine in enzymatic activity as probed by chemical modification and site- directed mutagenesis.
    Shriver Z, Hu Y, Pojasek K, Sasisekharan R.
    J Biol Chem; 1998 Sep 04; 273(36):22904-12. PubMed ID: 9722510
    [Abstract] [Full Text] [Related]

  • 13. Heparinase I from Flavobacterium heparinum. Mapping and characterization of the heparin binding domain.
    Sasisekharan R, Venkataraman G, Godavarti R, Ernst S, Cooney CL, Langer R.
    J Biol Chem; 1996 Feb 09; 271(6):3124-31. PubMed ID: 8621711
    [Abstract] [Full Text] [Related]

  • 14. The heparin/heparan sulfate 2-O-sulfatase from Flavobacterium heparinum. A structural and biochemical study of the enzyme active site and saccharide substrate specificity.
    Raman R, Myette JR, Shriver Z, Pojasek K, Venkataraman G, Sasisekharan R.
    J Biol Chem; 2003 Apr 04; 278(14):12167-74. PubMed ID: 12519774
    [Abstract] [Full Text] [Related]

  • 15. Active site of chondroitin AC lyase revealed by the structure of enzyme-oligosaccharide complexes and mutagenesis.
    Huang W, Boju L, Tkalec L, Su H, Yang HO, Gunay NS, Linhardt RJ, Kim YS, Matte A, Cygler M.
    Biochemistry; 2001 Feb 27; 40(8):2359-72. PubMed ID: 11327856
    [Abstract] [Full Text] [Related]

  • 16. Heparin/heparan sulfate N-sulfamidase from Flavobacterium heparinum: structural and biochemical investigation of catalytic nitrogen-sulfur bond cleavage.
    Myette JR, Soundararajan V, Behr J, Shriver Z, Raman R, Sasisekharan R.
    J Biol Chem; 2009 Dec 11; 284(50):35189-200. PubMed ID: 19726673
    [Abstract] [Full Text] [Related]

  • 17. Crystal structure of chondroitinase B from Flavobacterium heparinum and its complex with a disaccharide product at 1.7 A resolution.
    Huang W, Matte A, Li Y, Kim YS, Linhardt RJ, Su H, Cygler M.
    J Mol Biol; 1999 Dec 17; 294(5):1257-69. PubMed ID: 10600383
    [Abstract] [Full Text] [Related]

  • 18. Specificity studies on the heparin lyases from Flavobacterium heparinum.
    Desai UR, Wang HM, Linhardt RJ.
    Biochemistry; 1993 Aug 17; 32(32):8140-5. PubMed ID: 8347612
    [Abstract] [Full Text] [Related]

  • 19. Crystal structure of Pedobacter heparinus heparin lyase Hep III with the active site in a deep cleft.
    Hashimoto W, Maruyama Y, Nakamichi Y, Mikami B, Murata K.
    Biochemistry; 2014 Feb 04; 53(4):777-86. PubMed ID: 24437462
    [Abstract] [Full Text] [Related]

  • 20. Heparin/heparan sulfate 6-O-sulfatase from Flavobacterium heparinum: integrated structural and biochemical investigation of enzyme active site and substrate specificity.
    Myette JR, Soundararajan V, Shriver Z, Raman R, Sasisekharan R.
    J Biol Chem; 2009 Dec 11; 284(50):35177-88. PubMed ID: 19726671
    [Abstract] [Full Text] [Related]

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