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Journal Abstract Search

144 related items for PubMed ID: 20409708

  • 1. 3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts.
    Brnardic EJ, Fraley ME, Garbaccio RM, Layton ME, Sanders JM, Culberson C, Jacobson MA, Magliaro BC, Hutson PH, O'Brien JA, Huszar SL, Uslaner JM, Fillgrove KL, Tang C, Kuo Y, Sur SM, Hartman GD.
    Bioorg Med Chem Lett; 2010 May 15; 20(10):3129-33. PubMed ID: 20409708
    [Abstract] [Full Text] [Related]

  • 2. 3-Benzyl-1,3-oxazolidin-2-ones as mGluR2 positive allosteric modulators: Hit-to lead and lead optimization.
    Duplantier AJ, Efremov I, Candler J, Doran AC, Ganong AH, Haas JA, Hanks AN, Kraus KG, Lazzaro JT, Lu J, Maklad N, McCarthy SA, O'Sullivan TJ, Rogers BN, Siuciak JA, Spracklin DK, Zhang L.
    Bioorg Med Chem Lett; 2009 May 01; 19(9):2524-9. PubMed ID: 19328692
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  • 3. Benzazoles as allosteric potentiators of metabotropic glutamate receptor 2 (mGluR2): efficacy in an animal model for schizophrenia.
    Govek SP, Bonnefous C, Hutchinson JH, Kamenecka T, McQuiston J, Pracitto R, Zhao LX, Gardner MF, James JK, Daggett LP, Rowe BA, Schaffhauser H, Bristow LJ, Campbell UC, Rodriguez DE, Vernier JM.
    Bioorg Med Chem Lett; 2005 Sep 15; 15(18):4068-72. PubMed ID: 16005222
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  • 4. Positive allosteric modulators of the metabotropic glutamate receptor 2 for the treatment of schizophrenia.
    Fraley ME.
    Expert Opin Ther Pat; 2009 Sep 15; 19(9):1259-75. PubMed ID: 19552508
    [Abstract] [Full Text] [Related]

  • 5. Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice.
    Galici R, Jones CK, Hemstapat K, Nong Y, Echemendia NG, Williams LC, de Paulis T, Conn PJ.
    J Pharmacol Exp Ther; 2006 Jul 15; 318(1):173-85. PubMed ID: 16608916
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  • 6. Phenyl-tetrazolyl acetophenones: discovery of positive allosteric potentiatiors for the metabotropic glutamate 2 receptor.
    Pinkerton AB, Vernier JM, Schaffhauser H, Rowe BA, Campbell UC, Rodriguez DE, Lorrain DS, Baccei CS, Daggett LP, Bristow LJ.
    J Med Chem; 2004 Aug 26; 47(18):4595-9. PubMed ID: 15317469
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  • 7. Discovery of a potent and brain penetrant mGluR5 positive allosteric modulator.
    Ritzén A, Sindet R, Hentzer M, Svendsen N, Brodbeck RM, Bundgaard C.
    Bioorg Med Chem Lett; 2009 Jun 15; 19(12):3275-8. PubMed ID: 19443216
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  • 8. 3-(Imidazolyl methyl)-3-aza-bicyclo[3.1.0]hexan-6-yl)methyl ethers: a novel series of mGluR2 positive allosteric modulators.
    Zhang L, Rogers BN, Duplantier AJ, McHardy SF, Efremov I, Berke H, Qian W, Zhang AQ, Maklad N, Candler J, Doran AC, Lazzaro JT, Ganong AH.
    Bioorg Med Chem Lett; 2008 Oct 15; 18(20):5493-6. PubMed ID: 18812259
    [Abstract] [Full Text] [Related]

  • 9. Biphenyl-indanones: allosteric potentiators of the metabotropic glutamate subtype 2 receptor.
    Bonnefous C, Vernier JM, Hutchinson JH, Gardner MF, Cramer M, James JK, Rowe BA, Daggett LP, Schaffhauser H, Kamenecka TM.
    Bioorg Med Chem Lett; 2005 Oct 01; 15(19):4354-8. PubMed ID: 16046122
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  • 10. The identification of structurally novel, selective, orally bioavailable positive modulators of mGluR2.
    D'Alessandro PL, Corti C, Roth A, Ugolini A, Sava A, Montanari D, Bianchi F, Garland SL, Powney B, Koppe EL, Rocheville M, Osborne G, Perez P, de la Fuente J, De Los Frailes M, Smith PW, Branch C, Nash D, Watson SP.
    Bioorg Med Chem Lett; 2010 Jan 15; 20(2):759-62. PubMed ID: 20005096
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  • 12. Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 3: Identification and biological activity of indanone containing mGlu2 receptor potentiators.
    Pinkerton AB, Cube RV, Hutchinson JH, James JK, Gardner MF, Rowe BA, Schaffhauser H, Rodriguez DE, Campbell UC, Daggett LP, Vernier JM.
    Bioorg Med Chem Lett; 2005 Mar 15; 15(6):1565-71. PubMed ID: 15745798
    [Abstract] [Full Text] [Related]

  • 13. Effects of a positive allosteric modulator of mGluR5 ADX47273 on conditioned avoidance response and PCP-induced hyperlocomotion in the rat as models for schizophrenia.
    Schlumberger C, Pietraszek M, Gravius A, Danysz W.
    Pharmacol Biochem Behav; 2010 Mar 15; 95(1):23-30. PubMed ID: 19995568
    [Abstract] [Full Text] [Related]

  • 14. New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones.
    Trabanco AA, Duvey G, Cid JM, Macdonald GJ, Cluzeau P, Nhem V, Furnari R, Behaj N, Poulain G, Finn T, Lavreysen H, Poli S, Raux A, Thollon Y, Poirier N, D'Addona D, Andrés JI, Lutjens R, Le Poul E, Imogai H, Rocher JP.
    Bioorg Med Chem Lett; 2011 Feb 01; 21(3):971-6. PubMed ID: 21232953
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  • 18. The role of the mGluR allosteric modulation in the NMDA-hypofunction model of schizophrenia.
    Doreulee N, Alania M, Mitaishvili E, Chikovani M, Chkhartishvili B.
    Georgian Med News; 2009 Dec 01; (177):59-65. PubMed ID: 20090156
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  • 19. Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo.
    Lindsley CW, Wisnoski DD, Leister WH, O'brien JA, Lemaire W, Williams DL, Burno M, Sur C, Kinney GG, Pettibone DJ, Tiller PR, Smith S, Duggan ME, Hartman GD, Conn PJ, Huff JR.
    J Med Chem; 2004 Nov 18; 47(24):5825-8. PubMed ID: 15537338
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