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Journal Abstract Search

166 related items for PubMed ID: 20421447

  • 1. Species-specific metabolism of SGX523 by aldehyde oxidase and the toxicological implications.
    Diamond S, Boer J, Maduskuie TP, Falahatpisheh N, Li Y, Yeleswaram S.
    Drug Metab Dispos; 2010 Aug; 38(8):1277-85. PubMed ID: 20421447
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  • 2. Bioactivation of isothiazoles: minimizing the risk of potential toxicity in drug discovery.
    Teffera Y, Choquette D, Liu J, Colletti AE, Hollis LS, Lin MH, Zhao Z.
    Chem Res Toxicol; 2010 Nov 15; 23(11):1743-52. PubMed ID: 20825217
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  • 5. Preclinical pharmacokinetics and metabolism of 6-(4-(2,5-difluorophenyl)oxazol-5-yl)-3-isopropyl-[1,2,4]-triazolo[4,3-a]pyridine, a novel and selective p38alpha inhibitor: identification of an active metabolite in preclinical species and human liver microsomes.
    Kalgutkar AS, Hatch HL, Kosea F, Nguyen HT, Choo EF, McClure KF, Taylor TJ, Henne KR, Kuperman AV, Dombroski MA, Letavic MA.
    Biopharm Drug Dispos; 2006 Nov 15; 27(8):371-86. PubMed ID: 16944451
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  • 6. The in vitro hepatic metabolism of ABT-418, a cholinergic channel activator, in rats, dogs, cynomolgus monkeys, and humans.
    Rodrigues AD, Ferrero JL, Amann MT, Rotert GA, Cepa SP, Surber BW, Machinist JM, Tich NR, Sullivan JP, Garvey DS.
    Drug Metab Dispos; 1994 Nov 15; 22(5):788-98. PubMed ID: 7530622
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  • 9. Species differences in enantioselective 2-oxidations of RS-8359, a selective and reversible MAO-A inhibitor, and cinchona alkaloids by aldehyde oxidase.
    Itoh K, Yamamura M, Takasaki W, Sasaki T, Masubuchi A, Tanaka Y.
    Biopharm Drug Dispos; 2006 Apr 15; 27(3):133-9. PubMed ID: 16400710
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  • 10. Oxidative metabolic pathway of lenvatinib mediated by aldehyde oxidase.
    Inoue K, Mizuo H, Kawaguchi S, Fukuda K, Kusano K, Yoshimura T.
    Drug Metab Dispos; 2014 Aug 15; 42(8):1326-33. PubMed ID: 24914245
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  • 13. In vitro hepatic metabolism of ABT-418 in chimpanzee (Pan troglodytes). A unique pattern of microsomal flavin-containing monooxygenase-dependent stereoselective N'-oxidation.
    Rodrigues AD, Kukulka MJ, Ferrero JL, Cashman JR.
    Drug Metab Dispos; 1995 Oct 15; 23(10):1143-52. PubMed ID: 8654204
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  • 15. Metabolism and excretion of 6-chloro-9-(4-methoxy-3,5-dimethylpyridin-2-ylmethyl)-9H-purin-2-ylamine, an HSP90 inhibitor, in rats and dogs and assessment of its metabolic profile in plasma of humans.
    Xu L, Woodward C, Dai J, Prakash C.
    Drug Metab Dispos; 2013 Dec 15; 41(12):2133-47. PubMed ID: 24046333
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  • 18. Species differences in the toxicity and cytochrome P450 IIIA-dependent metabolism of digitoxin.
    Eberhart DC, Gemzik B, Halvorson MR, Parkinson A.
    Mol Pharmacol; 1991 Nov 15; 40(5):859-67. PubMed ID: 1944247
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  • 19. Zebularine metabolism by aldehyde oxidase in hepatic cytosol from humans, monkeys, dogs, rats, and mice: influence of sex and inhibitors.
    Klecker RW, Cysyk RL, Collins JM.
    Bioorg Med Chem; 2006 Jan 01; 14(1):62-6. PubMed ID: 16143537
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  • 20. A novel ring oxidation of 4- or 5-substituted 2H-oxazole to corresponding 2-oxazolone catalyzed by cytosolic aldehyde oxidase.
    Arora VK, Philip T, Huang S, Shu YZ.
    Drug Metab Dispos; 2012 Sep 01; 40(9):1668-76. PubMed ID: 22621803
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