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117 related items for PubMed ID: 20434437

  • 1. Differences among allelic variants of human glutathione transferase A2-2 in the activation of azathioprine.
    Zhang W, Modén O, Mannervik B.
    Chem Biol Interact; 2010 Jul 30; 186(2):110-7. PubMed ID: 20434437
    [Abstract] [Full Text] [Related]

  • 2. Divergent activities of human glutathione transferases in the bioactivation of azathioprine.
    Eklund BI, Moberg M, Bergquist J, Mannervik B.
    Mol Pharmacol; 2006 Aug 30; 70(2):747-54. PubMed ID: 16717136
    [Abstract] [Full Text] [Related]

  • 3. Structural determinants of glutathione transferases with azathioprine activity identified by DNA shuffling of alpha class members.
    Kurtovic S, Modén O, Shokeer A, Mannervik B.
    J Mol Biol; 2008 Feb 01; 375(5):1365-79. PubMed ID: 18155239
    [Abstract] [Full Text] [Related]

  • 4. Glutathione transferases in the bioactivation of azathioprine.
    Modén O, Mannervik B.
    Adv Cancer Res; 2014 Feb 01; 122():199-244. PubMed ID: 24974183
    [Abstract] [Full Text] [Related]

  • 5. Human glutathione transferases catalyzing the bioactivation of anticancer thiopurine prodrugs.
    Eklund BI, Gunnarsdottir S, Elfarra AA, Mannervik B.
    Biochem Pharmacol; 2007 Jun 01; 73(11):1829-41. PubMed ID: 17433263
    [Abstract] [Full Text] [Related]

  • 6. Mutational analysis of human glutathione transferase A2-2 identifies structural elements supporting high activity with the prodrug azathioprine.
    Modén O, Zhang W, Mannervik B.
    Protein Eng Des Sel; 2012 Apr 01; 25(4):189-97. PubMed ID: 22334756
    [Abstract] [Full Text] [Related]

  • 7. Differential catalytic efficiency of allelic variants of human glutathione S-transferase Pi in catalyzing the glutathione conjugation of thiotepa.
    Srivastava SK, Singhal SS, Hu X, Awasthi YC, Zimniak P, Singh SV.
    Arch Biochem Biophys; 1999 Jun 01; 366(1):89-94. PubMed ID: 10334868
    [Abstract] [Full Text] [Related]

  • 8. Glutathione transferase activity with a novel substrate mimics the activation of the prodrug azathioprine.
    Kurtovic S, Grehn L, Karlsson A, Hellman U, Mannervik B.
    Anal Biochem; 2008 Apr 15; 375(2):339-44. PubMed ID: 18211812
    [Abstract] [Full Text] [Related]

  • 9. The anti-cancer drug chlorambucil as a substrate for the human polymorphic enzyme glutathione transferase P1-1: kinetic properties and crystallographic characterisation of allelic variants.
    Parker LJ, Ciccone S, Italiano LC, Primavera A, Oakley AJ, Morton CJ, Hancock NC, Bello ML, Parker MW.
    J Mol Biol; 2008 Jun 27; 380(1):131-44. PubMed ID: 18511072
    [Abstract] [Full Text] [Related]

  • 10. Importance of a hypervariable active-site residue in human Mu class glutathione transferases catalyzing the bioactivation of chemotherapeutic thiopurine prodrugs.
    Eklund BI, Mannervik B.
    Biochim Biophys Acta; 2007 Aug 27; 1770(8):1098-103. PubMed ID: 17493759
    [Abstract] [Full Text] [Related]

  • 11. Functional studies of single-nucleotide polymorphic variants of human glutathione transferase T1-1 involving residues in the dimer interface.
    Josephy PD, Pan D, Ianni MD, Mannervik B.
    Arch Biochem Biophys; 2011 Sep 15; 513(2):87-93. PubMed ID: 21781954
    [Abstract] [Full Text] [Related]

  • 12. Structure-based redesign of GST A2-2 for enhanced catalytic efficiency with azathioprine.
    Zhang W, Modén O, Tars K, Mannervik B.
    Chem Biol; 2012 Mar 23; 19(3):414-21. PubMed ID: 22444596
    [Abstract] [Full Text] [Related]

  • 13. A comparison of the enzymatic and physicochemical properties of human glutathione transferase M4-4 and three other human Mu class enzymes.
    Comstock KE, Widersten M, Hao XY, Henner WD, Mannervik B.
    Arch Biochem Biophys; 1994 Jun 23; 311(2):487-95. PubMed ID: 8203914
    [Abstract] [Full Text] [Related]

  • 14. Involvement of the carboxyl groups of glutathione in the catalytic mechanism of human glutathione transferase A1-1.
    Widersten M, Björnestedt R, Mannervik B.
    Biochemistry; 1996 Jun 18; 35(24):7731-42. PubMed ID: 8672473
    [Abstract] [Full Text] [Related]

  • 15. Mechanism-based phage display selection of active-site mutants of human glutathione transferase A1-1 catalyzing SNAr reactions.
    Hansson LO, Widersten M, Mannervik B.
    Biochemistry; 1997 Sep 16; 36(37):11252-60. PubMed ID: 9287168
    [Abstract] [Full Text] [Related]

  • 16. A novel quasi-species of glutathione transferase with high activity towards naturally occurring isothiocyanates evolves from promiscuous low-activity variants.
    Runarsdottir A, Mannervik B.
    J Mol Biol; 2010 Aug 20; 401(3):451-64. PubMed ID: 20600121
    [Abstract] [Full Text] [Related]

  • 17. Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
    Gearry RB, Barclay ML.
    J Gastroenterol Hepatol; 2005 Aug 20; 20(8):1149-57. PubMed ID: 16048561
    [Abstract] [Full Text] [Related]

  • 18. Experimental conditions affecting functional comparison of highly active glutathione transferases.
    Fedulova N, Mannervik B.
    Anal Biochem; 2011 Jun 01; 413(1):16-23. PubMed ID: 21295006
    [Abstract] [Full Text] [Related]

  • 19. Multivariate-activity mining for molecular quasi-species in a glutathione transferase mutant library.
    Kurtovic S, Runarsdottir A, Emrén LO, Larsson AK, Mannervik B.
    Protein Eng Des Sel; 2007 May 01; 20(5):243-56. PubMed ID: 17468114
    [Abstract] [Full Text] [Related]

  • 20. Heterologous expression of the allelic variant mu-class glutathione transferases mu and psi.
    Widersten M, Pearson WR, Engström A, Mannervik B.
    Biochem J; 1991 Jun 01; 276 ( Pt 2)(Pt 2):519-24. PubMed ID: 2049077
    [Abstract] [Full Text] [Related]

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