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446 related items for PubMed ID: 20446724

  • 1. Mesd is a universal inhibitor of Wnt coreceptors LRP5 and LRP6 and blocks Wnt/beta-catenin signaling in cancer cells.
    Lu W, Liu CC, Thottassery JV, Bu G, Li Y.
    Biochemistry; 2010 Jun 08; 49(22):4635-43. PubMed ID: 20446724
    [Abstract] [Full Text] [Related]

  • 2. The C-terminal region Mesd peptide mimics full-length Mesd and acts as an inhibitor of Wnt/β-catenin signaling in cancer cells.
    Lin C, Lu W, Zhang W, Londoño-Joshi AI, Buchsbaum DJ, Bu G, Li Y.
    PLoS One; 2013 Jun 08; 8(2):e58102. PubMed ID: 23469146
    [Abstract] [Full Text] [Related]

  • 3. Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding.
    Li Y, Chen J, Lu W, McCormick LM, Wang J, Bu G.
    J Cell Sci; 2005 Nov 15; 118(Pt 22):5305-14. PubMed ID: 16263759
    [Abstract] [Full Text] [Related]

  • 4. Mesd is a general inhibitor of different Wnt ligands in Wnt/LRP signaling and inhibits PC-3 tumor growth in vivo.
    Lin C, Lu W, Zhai L, Bethea T, Berry K, Qu Z, Waud WR, Li Y.
    FEBS Lett; 2011 Oct 03; 585(19):3120-5. PubMed ID: 21907199
    [Abstract] [Full Text] [Related]

  • 5. Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6.
    Bourhis E, Tam C, Franke Y, Bazan JF, Ernst J, Hwang J, Costa M, Cochran AG, Hannoush RN.
    J Biol Chem; 2010 Mar 19; 285(12):9172-9. PubMed ID: 20093360
    [Abstract] [Full Text] [Related]

  • 6. A cell-based Dkk1 binding assay reveals roles for extracellular domains of LRP5 in Dkk1 interaction and highlights differences between wild-type and the high bone mass mutant LRP5(G171V).
    Murrills RJ, Matteo JJ, Bhat BM, Coleburn VE, Allen KM, Chen W, Damagnez V, Bhat RA, Bex FJ, Bodine PV.
    J Cell Biochem; 2009 Dec 01; 108(5):1066-75. PubMed ID: 19746449
    [Abstract] [Full Text] [Related]

  • 7. Inhibition of LRP5/6-mediated Wnt/β-catenin signaling by Mesd attenuates hyperoxia-induced pulmonary hypertension in neonatal rats.
    Alapati D, Rong M, Chen S, Lin C, Li Y, Wu S.
    Pediatr Res; 2013 Jun 01; 73(6):719-25. PubMed ID: 23481549
    [Abstract] [Full Text] [Related]

  • 8. Modulation of LRP6-mediated Wnt signaling by molecular chaperone Mesd.
    Li Y, Lu W, He X, Bu G.
    FEBS Lett; 2006 Oct 02; 580(22):5423-8. PubMed ID: 16989816
    [Abstract] [Full Text] [Related]

  • 9. Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies.
    Ettenberg SA, Charlat O, Daley MP, Liu S, Vincent KJ, Stuart DD, Schuller AG, Yuan J, Ospina B, Green J, Yu Q, Walsh R, Li S, Schmitz R, Heine H, Bilic S, Ostrom L, Mosher R, Hartlepp KF, Zhu Z, Fawell S, Yao YM, Stover D, Finan PM, Porter JA, Sellers WR, Klagge IM, Cong F.
    Proc Natl Acad Sci U S A; 2010 Aug 31; 107(35):15473-8. PubMed ID: 20713706
    [Abstract] [Full Text] [Related]

  • 10. Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity.
    Ellies DL, Viviano B, McCarthy J, Rey JP, Itasaki N, Saunders S, Krumlauf R.
    J Bone Miner Res; 2006 Nov 31; 21(11):1738-49. PubMed ID: 17002572
    [Abstract] [Full Text] [Related]

  • 11. Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling.
    Li X, Zhang Y, Kang H, Liu W, Liu P, Zhang J, Harris SE, Wu D.
    J Biol Chem; 2005 May 20; 280(20):19883-7. PubMed ID: 15778503
    [Abstract] [Full Text] [Related]

  • 12. Cooperative folding and ligand-binding properties of LRP6 beta-propeller domains.
    Liu CC, Pearson C, Bu G.
    J Biol Chem; 2009 May 29; 284(22):15299-307. PubMed ID: 19339249
    [Abstract] [Full Text] [Related]

  • 13. Lrp4, a novel receptor for Dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover in vivo.
    Choi HY, Dieckmann M, Herz J, Niemeier A.
    PLoS One; 2009 Nov 20; 4(11):e7930. PubMed ID: 19936252
    [Abstract] [Full Text] [Related]

  • 14. Opposing Roles of Wnt Inhibitors IGFBP-4 and Dkk1 in Cardiac Ischemia by Differential Targeting of LRP5/6 and β-catenin.
    Wo D, Peng J, Ren DN, Qiu L, Chen J, Zhu Y, Yan Y, Yan H, Wu J, Ma E, Zhong TP, Chen Y, Liu Z, Liu S, Ao L, Liu Z, Jiang C, Peng J, Zou Y, Qian Q, Zhu W.
    Circulation; 2016 Dec 13; 134(24):1991-2007. PubMed ID: 27803037
    [Abstract] [Full Text] [Related]

  • 15. Wnt-3a and Dickkopf-1 stimulate neurite outgrowth in Ewing tumor cells via a Frizzled3- and c-Jun N-terminal kinase-dependent mechanism.
    Endo Y, Beauchamp E, Woods D, Taylor WG, Toretsky JA, Uren A, Rubin JS.
    Mol Cell Biol; 2008 Apr 13; 28(7):2368-79. PubMed ID: 18212053
    [Abstract] [Full Text] [Related]

  • 16. The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo.
    Bryja V, Andersson ER, Schambony A, Esner M, Bryjová L, Biris KK, Hall AC, Kraft B, Cajanek L, Yamaguchi TP, Buckingham M, Arenas E.
    Mol Biol Cell; 2009 Feb 13; 20(3):924-36. PubMed ID: 19056682
    [Abstract] [Full Text] [Related]

  • 17. Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6.
    Semënov MV, Tamai K, Brott BK, Kühl M, Sokol S, He X.
    Curr Biol; 2001 Jun 26; 11(12):951-61. PubMed ID: 11448771
    [Abstract] [Full Text] [Related]

  • 18. Wnt3a and Dkk1 regulate distinct internalization pathways of LRP6 to tune the activation of beta-catenin signaling.
    Yamamoto H, Sakane H, Yamamoto H, Michiue T, Kikuchi A.
    Dev Cell; 2008 Jul 26; 15(1):37-48. PubMed ID: 18606139
    [Abstract] [Full Text] [Related]

  • 19. Expression, purification and functional characterization of Wnt signaling co-receptors LRP5 and LRP6.
    Fleury D, Vayssiere B, Touitou R, Gillard C, Lebhar H, Rawadi G, Mollat P.
    Protein Expr Purif; 2010 Mar 26; 70(1):39-47. PubMed ID: 19716419
    [Abstract] [Full Text] [Related]

  • 20. R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and beta-catenin signaling.
    Wei Q, Yokota C, Semenov MV, Doble B, Woodgett J, He X.
    J Biol Chem; 2007 May 25; 282(21):15903-11. PubMed ID: 17400545
    [Abstract] [Full Text] [Related]

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