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846 related items for PubMed ID: 20446772

  • 1. Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway.
    Hayes JD, McMahon M, Chowdhry S, Dinkova-Kostova AT.
    Antioxid Redox Signal; 2010 Dec 01; 13(11):1713-48. PubMed ID: 20446772
    [Abstract] [Full Text] [Related]

  • 2. Antioxidant-induced INrf2 (Keap1) tyrosine 85 phosphorylation controls the nuclear export and degradation of the INrf2-Cul3-Rbx1 complex to allow normal Nrf2 activation and repression.
    Kaspar JW, Niture SK, Jaiswal AK.
    J Cell Sci; 2012 Feb 15; 125(Pt 4):1027-38. PubMed ID: 22448038
    [Abstract] [Full Text] [Related]

  • 3. Review of molecular mechanisms involved in the activation of the Nrf2-ARE signaling pathway by chemopreventive agents.
    Giudice A, Arra C, Turco MC.
    Methods Mol Biol; 2010 Feb 15; 647():37-74. PubMed ID: 20694660
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  • 6. Discovery of the negative regulator of Nrf2, Keap1: a historical overview.
    Itoh K, Mimura J, Yamamoto M.
    Antioxid Redox Signal; 2010 Dec 01; 13(11):1665-78. PubMed ID: 20446768
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  • 7. Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2 x Keap1 x Cul3 complex and recruiting Nrf2 x Maf to the antioxidant response element enhancer.
    He X, Chen MG, Lin GX, Ma Q.
    J Biol Chem; 2006 Aug 18; 281(33):23620-31. PubMed ID: 16785233
    [Abstract] [Full Text] [Related]

  • 8. Activation of the Nrf2/ARE pathway via S-alkylation of cysteine 151 in the chemopreventive agent-sensor Keap1 protein by falcarindiol, a conjugated diacetylene compound.
    Ohnuma T, Nakayama S, Anan E, Nishiyama T, Ogura K, Hiratsuka A.
    Toxicol Appl Pharmacol; 2010 Apr 01; 244(1):27-36. PubMed ID: 20026152
    [Abstract] [Full Text] [Related]

  • 9. The Keap1-Nrf2 system as an in vivo sensor for electrophiles.
    Uruno A, Motohashi H.
    Nitric Oxide; 2011 Aug 01; 25(2):153-60. PubMed ID: 21385624
    [Abstract] [Full Text] [Related]

  • 10. Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2.
    Sun Z, Zhang S, Chan JY, Zhang DD.
    Mol Cell Biol; 2007 Sep 01; 27(18):6334-49. PubMed ID: 17636022
    [Abstract] [Full Text] [Related]

  • 11. CAND1-mediated substrate adaptor recycling is required for efficient repression of Nrf2 by Keap1.
    Lo SC, Hannink M.
    Mol Cell Biol; 2006 Feb 01; 26(4):1235-44. PubMed ID: 16449638
    [Abstract] [Full Text] [Related]

  • 12. Action of Nrf2 and Keap1 in ARE-mediated NQO1 expression by quercetin.
    Tanigawa S, Fujii M, Hou DX.
    Free Radic Biol Med; 2007 Jun 01; 42(11):1690-703. PubMed ID: 17462537
    [Abstract] [Full Text] [Related]

  • 13. Zinc-binding triggers a conformational-switch in the cullin-3 substrate adaptor protein KEAP1 that controls transcription factor NRF2.
    McMahon M, Swift SR, Hayes JD.
    Toxicol Appl Pharmacol; 2018 Dec 01; 360():45-57. PubMed ID: 30261176
    [Abstract] [Full Text] [Related]

  • 14. Regulation of the Nrf2-Keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases.
    Villeneuve NF, Lau A, Zhang DD.
    Antioxid Redox Signal; 2010 Dec 01; 13(11):1699-712. PubMed ID: 20486766
    [Abstract] [Full Text] [Related]

  • 15. Nrf2: a potential molecular target for cancer chemoprevention by natural compounds.
    Jeong WS, Jun M, Kong AN.
    Antioxid Redox Signal; 2006 Dec 01; 8(1-2):99-106. PubMed ID: 16487042
    [Abstract] [Full Text] [Related]

  • 16. Molecular cross-talk between the NRF2/KEAP1 signaling pathway, autophagy, and apoptosis.
    Stępkowski TM, Kruszewski MK.
    Free Radic Biol Med; 2011 May 01; 50(9):1186-95. PubMed ID: 21295136
    [Abstract] [Full Text] [Related]

  • 17. Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1.
    Eggler AL, Small E, Hannink M, Mesecar AD.
    Biochem J; 2009 Jul 29; 422(1):171-80. PubMed ID: 19489739
    [Abstract] [Full Text] [Related]

  • 18. Chemopreventive promise of targeting the Nrf2 pathway.
    Yates MS, Kensler TW.
    Drug News Perspect; 2007 Mar 29; 20(2):109-17. PubMed ID: 17440634
    [Abstract] [Full Text] [Related]

  • 19. Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation.
    Kobayashi M, Yamamoto M.
    Antioxid Redox Signal; 2005 Mar 29; 7(3-4):385-94. PubMed ID: 15706085
    [Abstract] [Full Text] [Related]

  • 20. Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution.
    Taguchi K, Motohashi H, Yamamoto M.
    Genes Cells; 2011 Feb 29; 16(2):123-40. PubMed ID: 21251164
    [Abstract] [Full Text] [Related]

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