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1208 related items for PubMed ID: 20451633

  • 1. Beat-by-beat QT interval variability, but not QT prolongation per se, predicts drug-induced torsades de pointes in the anaesthetised methoxamine-sensitized rabbit.
    Jacobson I, Carlsson L, Duker G.
    J Pharmacol Toxicol Methods; 2011; 63(1):40-6. PubMed ID: 20451633
    [Abstract] [Full Text] [Related]

  • 2. Assessment of the ion channel-blocking profile of the novel combined ion channel blocker AZD1305 and its proarrhythmic potential versus dofetilide in the methoxamine-sensitized rabbit in vivo.
    Carlsson L, Andersson B, Linhardt G, Löfberg L.
    J Cardiovasc Pharmacol; 2009 Jul; 54(1):82-9. PubMed ID: 19528812
    [Abstract] [Full Text] [Related]

  • 3. Beat-to-Beat variability of repolarization determines proarrhythmic outcome in dogs susceptible to drug-induced torsades de pointes.
    Thomsen MB, Volders PG, Beekman JD, Matz J, Vos MA.
    J Am Coll Cardiol; 2006 Sep 19; 48(6):1268-76. PubMed ID: 16979017
    [Abstract] [Full Text] [Related]

  • 4. Assessment of efficacy of proarrhythmia biomarkers in isolated rabbit hearts with attenuated repolarization reserve.
    Orosz S, Sarusi A, Csík N, Papp JG, Varró A, Farkas S, Forster T, Farkas AS, Farkas A.
    J Cardiovasc Pharmacol; 2014 Sep 19; 64(3):266-76. PubMed ID: 24887684
    [Abstract] [Full Text] [Related]

  • 5. Antiarrhythmic properties of a rapid delayed-rectifier current activator in rabbit models of acquired long QT syndrome.
    Diness TG, Yeh YH, Qi XY, Chartier D, Tsuji Y, Hansen RS, Olesen SP, Grunnet M, Nattel S.
    Cardiovasc Res; 2008 Jul 01; 79(1):61-9. PubMed ID: 18367457
    [Abstract] [Full Text] [Related]

  • 6. Combined pharmacological block of I(Kr) and I(Ks) increases short-term QT interval variability and provokes torsades de pointes.
    Lengyel C, Varró A, Tábori K, Papp JG, Baczkó I.
    Br J Pharmacol; 2007 Aug 01; 151(7):941-51. PubMed ID: 17533421
    [Abstract] [Full Text] [Related]

  • 7. Synergistic Effect of Dofetilide and Mexiletine on Prevention of Atrial Fibrillation.
    Liu G, Xue X, Gao C, Huang J, Qi D, Zhang Y, Dong JZ, Ma CS, Yan GX.
    J Am Heart Assoc; 2017 May 18; 6(5):. PubMed ID: 28522677
    [Abstract] [Full Text] [Related]

  • 8. Models of torsades de pointes: effects of FPL64176, DPI201106, dofetilide, and chromanol 293B in isolated rabbit and guinea pig hearts.
    Cheng HC, Incardona J.
    J Pharmacol Toxicol Methods; 2009 May 18; 60(2):174-84. PubMed ID: 19524054
    [Abstract] [Full Text] [Related]

  • 9. A new biomarker--index of cardiac electrophysiological balance (iCEB)--plays an important role in drug-induced cardiac arrhythmias: beyond QT-prolongation and Torsades de Pointes (TdPs).
    Lu HR, Yan GX, Gallacher DJ.
    J Pharmacol Toxicol Methods; 2013 May 18; 68(2):250-259. PubMed ID: 23337247
    [Abstract] [Full Text] [Related]

  • 10. K201, a multi-channel blocker, inhibits clofilium-induced torsades de pointes and attenuates an increase in repolarization.
    Hasumi H, Matsuda R, Shimamoto K, Hata Y, Kaneko N.
    Eur J Pharmacol; 2007 Jan 19; 555(1):54-60. PubMed ID: 17112502
    [Abstract] [Full Text] [Related]

  • 11. Assessment of drug-induced proarrhythmia: The importance of study design in the rabbit left ventricular wedge model.
    Lu HR, Gallacher DJ, Yan GX.
    J Pharmacol Toxicol Methods; 2016 Jan 19; 81():151-60. PubMed ID: 27374776
    [Abstract] [Full Text] [Related]

  • 12. No proarrhythmic properties of the antibiotics Moxifloxacin or Azithromycin in anaesthetized dogs with chronic-AV block.
    Thomsen MB, Beekman JD, Attevelt NJ, Takahara A, Sugiyama A, Chiba K, Vos MA.
    Br J Pharmacol; 2006 Dec 19; 149(8):1039-48. PubMed ID: 17088870
    [Abstract] [Full Text] [Related]

  • 13. New in vitro model for proarrhythmia safety screening: IKs inhibition potentiates the QTc prolonging effect of IKr inhibitors in isolated guinea pig hearts.
    Kui P, Orosz S, Takács H, Sarusi A, Csík N, Rárosi F, Csekő C, Varró A, Papp JG, Forster T, Farkas AS, Farkas A.
    J Pharmacol Toxicol Methods; 2016 Dec 19; 80():26-34. PubMed ID: 27063345
    [Abstract] [Full Text] [Related]

  • 14. Vernakalant is devoid of proarrhythmic effects in the complete AV block dog model.
    Varkevisser R, van der Heyden MA, Tieland RG, Beekman JD, Vos MA.
    Eur J Pharmacol; 2013 Nov 15; 720(1-3):49-54. PubMed ID: 24211677
    [Abstract] [Full Text] [Related]

  • 15. Assessment of the proarrhythmic potential of the novel antiarrhythmic agent AZD7009 and dofetilide in experimental models of torsades de pointes.
    Wu Y, Carlsson L, Liu T, Kowey PR, Yan GX.
    J Cardiovasc Electrophysiol; 2005 Aug 15; 16(8):898-904. PubMed ID: 16101634
    [Abstract] [Full Text] [Related]

  • 16. Beat-to-beat variability of QT intervals is increased in patients with drug-induced long-QT syndrome: a case control pilot study.
    Hinterseer M, Thomsen MB, Beckmann BM, Pfeufer A, Schimpf R, Wichmann HE, Steinbeck G, Vos MA, Kaab S.
    Eur Heart J; 2008 Jan 15; 29(2):185-90. PubMed ID: 18156612
    [Abstract] [Full Text] [Related]

  • 17. Biomarkers and endogenous determinants of dofetilide-induced torsades de pointes in α(1) -adrenoceptor-stimulated, anaesthetized rabbits.
    Farkas AS, Rudas L, Makra P, Csík N, Leprán I, Forster T, Csanády M, Papp JG, Varró A, Farkas A.
    Br J Pharmacol; 2010 Dec 15; 161(7):1477-95. PubMed ID: 20659107
    [Abstract] [Full Text] [Related]

  • 18. Tedisamil and dofetilide-induced torsades de pointes, rate and potassium dependence.
    Barrett TD, Hennan JK, Fischbach PS, O'Neill BP, Driscoll EM, Lucchesi BR.
    Br J Pharmacol; 2001 Apr 15; 132(7):1493-500. PubMed ID: 11264243
    [Abstract] [Full Text] [Related]

  • 19. Proarrhythmic effects of the class III agent almokalant: importance of infusion rate, QT dispersion, and early afterdepolarisations.
    Carlsson L, Abrahamsson C, Andersson B, Duker G, Schiller-Linhardt G.
    Cardiovasc Res; 1993 Dec 15; 27(12):2186-93. PubMed ID: 8313427
    [Abstract] [Full Text] [Related]

  • 20. Atrial-specific drug AVE0118 is free of torsades de pointes in anesthetized dogs with chronic complete atrioventricular block.
    Oros A, Volders PG, Beekman JD, van der Nagel T, Vos MA.
    Heart Rhythm; 2006 Nov 15; 3(11):1339-45. PubMed ID: 17074641
    [Abstract] [Full Text] [Related]

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