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Journal Abstract Search

513 related items for PubMed ID: 20460383

  • 1. A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity.
    Heilig EA, Xia W, Shen J, Kelleher RJ.
    J Biol Chem; 2010 Jul 16; 285(29):22350-9. PubMed ID: 20460383
    [Abstract] [Full Text] [Related]

  • 2. Suppressor Mutations for Presenilin 1 Familial Alzheimer Disease Mutants Modulate γ-Secretase Activities.
    Futai E, Osawa S, Cai T, Fujisawa T, Ishiura S, Tomita T.
    J Biol Chem; 2016 Jan 01; 291(1):435-46. PubMed ID: 26559975
    [Abstract] [Full Text] [Related]

  • 3. Conformational Models of APP Processing by Gamma Secretase Based on Analysis of Pathogenic Mutations.
    Kim M, Bezprozvanny I.
    Int J Mol Sci; 2021 Dec 18; 22(24):. PubMed ID: 34948396
    [Abstract] [Full Text] [Related]

  • 4. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
    Bentahir M, Nyabi O, Verhamme J, Tolia A, Horré K, Wiltfang J, Esselmann H, De Strooper B.
    J Neurochem; 2006 Feb 18; 96(3):732-42. PubMed ID: 16405513
    [Abstract] [Full Text] [Related]

  • 5. Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified γ-secretase complexes.
    Cacquevel M, Aeschbach L, Houacine J, Fraering PC.
    PLoS One; 2012 Feb 18; 7(4):e35133. PubMed ID: 22529981
    [Abstract] [Full Text] [Related]

  • 6. Nicastrin is dispensable for gamma-secretase protease activity in the presence of specific presenilin mutations.
    Futai E, Yagishita S, Ishiura S.
    J Biol Chem; 2009 May 08; 284(19):13013-22. PubMed ID: 19254953
    [Abstract] [Full Text] [Related]

  • 7. Decreased Abeta secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1.
    Shimojo M, Sahara N, Murayama M, Ichinose H, Takashima A.
    Neurosci Res; 2007 Mar 08; 57(3):446-53. PubMed ID: 17210196
    [Abstract] [Full Text] [Related]

  • 8. G206D Mutation of Presenilin-1 Reduces Pen2 Interaction, Increases Aβ42/Aβ40 Ratio and Elevates ER Ca(2+) Accumulation.
    Chen WT, Hsieh YF, Huang YJ, Lin CC, Lin YT, Liu YC, Lien CC, Cheng IH.
    Mol Neurobiol; 2015 Dec 08; 52(3):1835-1849. PubMed ID: 25394380
    [Abstract] [Full Text] [Related]

  • 9. Analysis of Non-Amyloidogenic Mutations in APP Supports Loss of Function Hypothesis of Alzheimer's Disease.
    Kim M, Bezprozvanny I.
    Int J Mol Sci; 2023 Jan 20; 24(3):. PubMed ID: 36768421
    [Abstract] [Full Text] [Related]

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  • 11. Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations.
    Czirr E, Leuchtenberger S, Dorner-Ciossek C, Schneider A, Jucker M, Koo EH, Pietrzik CU, Baumann K, Weggen S.
    J Biol Chem; 2007 Aug 24; 282(34):24504-13. PubMed ID: 17573346
    [Abstract] [Full Text] [Related]

  • 12. Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta.
    Shimojo M, Sahara N, Mizoroki T, Funamoto S, Morishima-Kawashima M, Kudo T, Takeda M, Ihara Y, Ichinose H, Takashima A.
    J Biol Chem; 2008 Jun 13; 283(24):16488-96. PubMed ID: 18430735
    [Abstract] [Full Text] [Related]

  • 13. Minor contribution of presenilin 2 for γ-secretase activity in mouse embryonic fibroblasts and adult mouse brain.
    Frånberg J, Svensson AI, Winblad B, Karlström H, Frykman S.
    Biochem Biophys Res Commun; 2011 Jan 07; 404(1):564-8. PubMed ID: 21146496
    [Abstract] [Full Text] [Related]

  • 14. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
    Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, Koo EH, Shen J, Selkoe DJ.
    Biochemistry; 1998 Nov 24; 37(47):16465-71. PubMed ID: 9843412
    [Abstract] [Full Text] [Related]

  • 15. Human Presenilin-1 delivered by AAV9 rescues impaired γ-secretase activity, memory deficits, and neurodegeneration in Psen mutant mice.
    Montenegro P, Chen P, Kang J, Lee SH, Leone S, Shen J.
    Proc Natl Acad Sci U S A; 2023 Oct 17; 120(42):e2306714120. PubMed ID: 37816062
    [Abstract] [Full Text] [Related]

  • 16. Specificity of presenilin-1- and presenilin-2-dependent γ-secretases towards substrate processing.
    Stanga S, Vrancx C, Tasiaux B, Marinangeli C, Karlström H, Kienlen-Campard P.
    J Cell Mol Med; 2018 Feb 17; 22(2):823-833. PubMed ID: 28994238
    [Abstract] [Full Text] [Related]

  • 17. Evidence that enzyme processivity mediates differential Aβ production by PS1 and PS2.
    Pintchovski SA, Schenk DB, Basi GS.
    Curr Alzheimer Res; 2013 Jan 17; 10(1):4-10. PubMed ID: 22950863
    [Abstract] [Full Text] [Related]

  • 18. Flexible and Accurate Substrate Processing with Distinct Presenilin/γ-Secretases in Human Cortical Neurons.
    Watanabe H, Imaizumi K, Cai T, Zhou Z, Tomita T, Okano H.
    eNeuro; 2021 Jan 17; 8(2):. PubMed ID: 33608391
    [Abstract] [Full Text] [Related]

  • 19. Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.
    Mastrangelo P, Mathews PM, Chishti MA, Schmidt SD, Gu Y, Yang J, Mazzella MJ, Coomaraswamy J, Horne P, Strome B, Pelly H, Levesque G, Ebeling C, Jiang Y, Nixon RA, Rozmahel R, Fraser PE, St George-Hyslop P, Carlson GA, Westaway D.
    Proc Natl Acad Sci U S A; 2005 Jun 21; 102(25):8972-7. PubMed ID: 15951428
    [Abstract] [Full Text] [Related]

  • 20. Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.
    Steiner H, Capell A, Leimer U, Haass C.
    Eur Arch Psychiatry Clin Neurosci; 1999 Jun 21; 249(6):266-70. PubMed ID: 10653281
    [Abstract] [Full Text] [Related]

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