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Journal Abstract Search

561 related items for PubMed ID: 20463577

  • 1. New concept in nutrition for the maintenance of the aging eye redox regulation and therapeutic treatment of cataract disease; synergism of natural antioxidant imidazole-containing amino acid-based compounds, chaperone, and glutathione boosting agents: a systemic perspective on aging and longevity emerged from studies in humans.
    Babizhayev MA.
    Am J Ther; 2010; 17(4):373-89. PubMed ID: 20463577
    [Abstract] [Full Text] [Related]

  • 2. N-acetylcarnosine lubricant eyedrops possess all-in-one universal antioxidant protective effects of L-carnosine in aqueous and lipid membrane environments, aldehyde scavenging, and transglycation activities inherent to cataracts: a clinical study of the new vision-saving drug N-acetylcarnosine eyedrop therapy in a database population of over 50,500 patients.
    Babizhayev MA, Micans P, Guiotto A, Kasus-Jacobi A.
    Am J Ther; 2009; 16(6):517-33. PubMed ID: 19487926
    [Abstract] [Full Text] [Related]

  • 3. Mitochondria induce oxidative stress, generation of reactive oxygen species and redox state unbalance of the eye lens leading to human cataract formation: disruption of redox lens organization by phospholipid hydroperoxides as a common basis for cataract disease.
    Babizhayev MA.
    Cell Biochem Funct; 2011 Apr; 29(3):183-206. PubMed ID: 21381059
    [Abstract] [Full Text] [Related]

  • 4. State of the art clinical efficacy and safety evaluation of N-acetylcarnosine dipeptide ophthalmic prodrug. Principles for the delivery, self-bioactivation, molecular targets and interaction with a highly evolved histidyl-hydrazide structure in the treatment and therapeutic management of a group of sight-threatening eye diseases.
    Babizhayev MA, Kasus-Jacobi A.
    Curr Clin Pharmacol; 2009 Jan; 4(1):4-37. PubMed ID: 19149498
    [Abstract] [Full Text] [Related]

  • 5. Telomere Attrition in Human Lens Epithelial Cells Associated with Oxidative Stress Provide a New Therapeutic Target for the Treatment, Dissolving and Prevention of Cataract with N-Acetylcarnosine Lubricant Eye Drops. Kinetic, Pharmacological and Activity-Dependent Separation of Therapeutic Targeting: Transcorneal Penetration and Delivery of L-Carnosine in the Aqueous Humor and Hormone-Like Hypothalamic Antiaging Effects of the Instilled Ophthalmic Drug Through a Safe Eye Medication Technique.
    Babizhayev MA, Yegorov YE.
    Recent Pat Drug Deliv Formul; 2016 Jan; 10(2):82-129. PubMed ID: 26084629
    [Abstract] [Full Text] [Related]

  • 6. Biomarkers and special features of oxidative stress in the anterior segment of the eye linked to lens cataract and the trabecular meshwork injury in primary open-angle glaucoma: challenges of dual combination therapy with N-acetylcarnosine lubricant eye drops and oral formulation of nonhydrolyzed carnosine.
    Babizhayev MA.
    Fundam Clin Pharmacol; 2012 Feb; 26(1):86-117. PubMed ID: 21883446
    [Abstract] [Full Text] [Related]

  • 7. Potentiation of intraocular absorption and drug metabolism of N-acetylcarnosine lubricant eye drops: drug interaction with sight threatening lipid peroxides in the treatment for age-related eye diseases.
    Babizhayev MA.
    Drug Metabol Drug Interact; 2009 Feb; 24(2-4):275-323. PubMed ID: 20408504
    [Abstract] [Full Text] [Related]

  • 8. Structural and functional properties, chaperone activity and posttranslational modifications of alpha-crystallin and its related subunits in the crystalline lens: N-acetylcarnosine, carnosine and carcinine act as alpha- crystallin/small heat shock protein enhancers in prevention and dissolution of cataract in ocular drug delivery formulations of novel therapeutic agents.
    Babizhayev MA.
    Recent Pat Drug Deliv Formul; 2012 Aug; 6(2):107-48. PubMed ID: 22436026
    [Abstract] [Full Text] [Related]

  • 9. Biological activities of the natural imidazole-containing peptidomimetics n-acetylcarnosine, carcinine and L-carnosine in ophthalmic and skin care products.
    Babizhayev MA.
    Life Sci; 2006 Apr 11; 78(20):2343-57. PubMed ID: 16388826
    [Abstract] [Full Text] [Related]

  • 10. Bioactivation antioxidant and transglycating properties of N-acetylcarnosine autoinduction prodrug of a dipeptide L-carnosine in mucoadhesive drug delivery eye-drop formulation: powerful eye health application technique and therapeutic platform.
    Babizhayev MA.
    Drug Test Anal; 2012 Jun 11; 4(6):468-85. PubMed ID: 21416634
    [Abstract] [Full Text] [Related]

  • 11. An "enigmatic" L-carnosine (β-alanyl-L-histidine)? Cell proliferative activity as a fundamental property of a natural dipeptide inherent to traditional antioxidant, anti-aging biological activities: balancing and a hormonally correct agent, novel patented oral therapy dosage formulation for mobility, skeletal muscle power and functional performance, hypothalamic-pituitary- brain relationship in health, aging and stress studies.
    Babizhayev MA, Yegorov YE.
    Recent Pat Drug Deliv Formul; 2015 Jun 11; 9(1):1-64. PubMed ID: 25524476
    [Abstract] [Full Text] [Related]

  • 12. N-Acetylcarnosine sustained drug delivery eye drops to control the signs of ageless vision: glare sensitivity, cataract amelioration and quality of vision currently available treatment for the challenging 50,000-patient population.
    Babizhayev MA, Burke L, Micans P, Richer SP.
    Clin Interv Aging; 2009 Jun 11; 4():31-50. PubMed ID: 19503764
    [Abstract] [Full Text] [Related]

  • 13. Reactive Oxygen Species and the Aging Eye: Specific Role of Metabolically Active Mitochondria in Maintaining Lens Function and in the Initiation of the Oxidation-Induced Maturity Onset Cataract--A Novel Platform of Mitochondria-Targeted Antioxidants With Broad Therapeutic Potential for Redox Regulation and Detoxification of Oxidants in Eye Diseases.
    Babizhayev MA, Yegorov YE.
    Am J Ther; 2016 Jun 11; 23(1):e98-117. PubMed ID: 21048433
    [Abstract] [Full Text] [Related]

  • 14. Designation of imidazole-containing dipeptides as pharmacological chaperones.
    Babizhayev MA.
    Hum Exp Toxicol; 2011 Jul 11; 30(7):736-61. PubMed ID: 20656726
    [Abstract] [Full Text] [Related]

  • 15. Novel intraocular and systemic absorption drug delivery and efficacy of N-acetylcarnosine lubricant eye drops or carcinine biologics in pharmaceutical usage and therapeutic vision care.
    Babizhayev MA, Khoroshilova-Maslova IP, Kasus-Jacobi A.
    Fundam Clin Pharmacol; 2012 Oct 11; 26(5):644-78. PubMed ID: 21793899
    [Abstract] [Full Text] [Related]

  • 16. Analysis of lipid peroxidation and electron microscopic survey of maturation stages during human cataractogenesis: pharmacokinetic assay of Can-C N-acetylcarnosine prodrug lubricant eye drops for cataract prevention.
    Babizhayev MA.
    Drugs R D; 2005 Oct 11; 6(6):345-69. PubMed ID: 16274259
    [Abstract] [Full Text] [Related]

  • 17. The natural histidine-containing dipeptide Nalpha-acetylcarnosine as an antioxidant for ophthalmic use.
    Babizhayev MA, Yermakova VN, Semiletov YA, Deyev AI.
    Biochemistry (Mosc); 2000 May 11; 65(5):588-98. PubMed ID: 10851037
    [Abstract] [Full Text] [Related]

  • 18. Biologic activities of molecular chaperones and pharmacologic chaperone imidazole-containing dipeptide-based compounds: natural skin care help and the ultimate challenge: implication for adaptive responses in the skin.
    Babizhayev MA, Nikolayev GM, Nikolayeva JG, Yegorov YE.
    Am J Ther; 2012 Mar 11; 19(2):e69-89. PubMed ID: 20861720
    [Abstract] [Full Text] [Related]

  • 19. Novel neuroendocrine and metabolic mechanism provides the patented platform for important rejuvenation therapies: targeted therapy of telomere attrition and lifestyle changes of telomerase activity with the timing of neuron-specific imidazole-containing dipeptide-dominant pharmaconutrition provision.
    Babizhayev MA, Kasus-Jacobi A, Vishnyakova KS, Yegorov YE.
    Recent Pat Endocr Metab Immune Drug Discov; 2014 Mar 11; 8(3):153-79. PubMed ID: 24910283
    [Abstract] [Full Text] [Related]

  • 20. Telomere-dependent senescent phenotype of lens epithelial cells as a biological marker of aging and cataractogenesis: the role of oxidative stress intensity and specific mechanism of phospholipid hydroperoxide toxicity in lens and aqueous.
    Babizhayev MA, Vishnyakova KS, Yegorov YE.
    Fundam Clin Pharmacol; 2011 Apr 11; 25(2):139-62. PubMed ID: 20412312
    [Abstract] [Full Text] [Related]

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