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Journal Abstract Search

297 related items for PubMed ID: 20493882

  • 1. Crystal structure of fatty acid amide hydrolase bound to the carbamate inhibitor URB597: discovery of a deacylating water molecule and insight into enzyme inactivation.
    Mileni M, Kamtekar S, Wood DC, Benson TE, Cravatt BF, Stevens RC.
    J Mol Biol; 2010 Jul 23; 400(4):743-54. PubMed ID: 20493882
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  • 2. Chemical and mutagenic investigations of fatty acid amide hydrolase: evidence for a family of serine hydrolases with distinct catalytic properties.
    Patricelli MP, Lovato MA, Cravatt BF.
    Biochemistry; 1999 Aug 03; 38(31):9804-12. PubMed ID: 10433686
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  • 3. Binding and inactivation mechanism of a humanized fatty acid amide hydrolase by alpha-ketoheterocycle inhibitors revealed from cocrystal structures.
    Mileni M, Garfunkle J, DeMartino JK, Cravatt BF, Boger DL, Stevens RC.
    J Am Chem Soc; 2009 Aug 05; 131(30):10497-506. PubMed ID: 19722626
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  • 6. Quantum mechanics/molecular mechanics modeling of fatty acid amide hydrolase reactivation distinguishes substrate from irreversible covalent inhibitors.
    Lodola A, Capoferri L, Rivara S, Tarzia G, Piomelli D, Mulholland A, Mor M.
    J Med Chem; 2013 Mar 28; 56(6):2500-12. PubMed ID: 23425199
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  • 8. Mechanism of carbamate inactivation of FAAH: implications for the design of covalent inhibitors and in vivo functional probes for enzymes.
    Alexander JP, Cravatt BF.
    Chem Biol; 2005 Nov 28; 12(11):1179-87. PubMed ID: 16298297
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  • 10. ω-Imidazolyl- and ω-Tetrazolylalkylcarbamates as Inhibitors of Fatty Acid Amide Hydrolase: Biological Activity and in vitro Metabolic Stability.
    Terwege T, Hanekamp W, Garzinsky D, König S, Koch O, Lehr M.
    ChemMedChem; 2016 Feb 17; 11(4):429-43. PubMed ID: 26732805
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  • 11. Synthesis and structure-activity relationships of FAAH inhibitors: cyclohexylcarbamic acid biphenyl esters with chemical modulation at the proximal phenyl ring.
    Tarzia G, Duranti A, Gatti G, Piersanti G, Tontini A, Rivara S, Lodola A, Plazzi PV, Mor M, Kathuria S, Piomelli D.
    ChemMedChem; 2006 Jan 17; 1(1):130-9. PubMed ID: 16892344
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  • 19. Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).
    Korhonen J, Kuusisto A, van Bruchem J, Patel JZ, Laitinen T, Navia-Paldanius D, Laitinen JT, Savinainen JR, Parkkari T, Nevalainen TJ.
    Bioorg Med Chem; 2014 Dec 01; 22(23):6694-6705. PubMed ID: 25282655
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