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840 related items for PubMed ID: 20504915

  • 1. In vitro pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107.
    Malysz J, Anderson DJ, Grønlien JH, Ji J, Bunnelle WH, Håkerud M, Thorin-Hagene K, Ween H, Helfrich R, Hu M, Gubbins E, Gopalakrishnan S, Puttfarcken PS, Briggs CA, Li J, Meyer MD, Dyhring T, Ahring PK, Nielsen EØ, Peters D, Timmermann DB, Gopalakrishnan M.
    J Pharmacol Exp Ther; 2010 Sep 01; 334(3):863-74. PubMed ID: 20504915
    [Abstract] [Full Text] [Related]

  • 2. In vitro pharmacological characterization of a novel allosteric modulator of alpha 7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), exhibiting unique pharmacological profile.
    Malysz J, Grønlien JH, Anderson DJ, Håkerud M, Thorin-Hagene K, Ween H, Wetterstrand C, Briggs CA, Faghih R, Bunnelle WH, Gopalakrishnan M.
    J Pharmacol Exp Ther; 2009 Jul 01; 330(1):257-67. PubMed ID: 19389923
    [Abstract] [Full Text] [Related]

  • 3. In vivo pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107: preclinical considerations in Alzheimer's disease.
    Bitner RS, Bunnelle WH, Decker MW, Drescher KU, Kohlhaas KL, Markosyan S, Marsh KC, Nikkel AL, Browman K, Radek R, Anderson DJ, Buccafusco J, Gopalakrishnan M.
    J Pharmacol Exp Ther; 2010 Sep 01; 334(3):875-86. PubMed ID: 20504913
    [Abstract] [Full Text] [Related]

  • 4. JN403, in vitro characterization of a novel nicotinic acetylcholine receptor alpha7 selective agonist.
    Feuerbach D, Nozulak J, Lingenhoehl K, McAllister K, Hoyer D.
    Neurosci Lett; 2007 Apr 06; 416(1):61-5. PubMed ID: 17314009
    [Abstract] [Full Text] [Related]

  • 5. Old and new pharmacology: positive allosteric modulation of the alpha7 nicotinic acetylcholine receptor by the 5-hydroxytryptamine(2B/C) receptor antagonist SB-206553 (3,5-dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b']di pyrrole-1(2H)-carboxamide).
    Dunlop J, Lock T, Jow B, Sitzia F, Grauer S, Jow F, Kramer A, Bowlby MR, Randall A, Kowal D, Gilbert A, Comery TA, Larocque J, Soloveva V, Brown J, Roncarati R.
    J Pharmacol Exp Ther; 2009 Mar 06; 328(3):766-76. PubMed ID: 19050173
    [Abstract] [Full Text] [Related]

  • 6. Procognitive and neuroprotective activity of a novel alpha7 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders.
    Roncarati R, Scali C, Comery TA, Grauer SM, Aschmi S, Bothmann H, Jow B, Kowal D, Gianfriddo M, Kelley C, Zanelli U, Ghiron C, Haydar S, Dunlop J, Terstappen GC.
    J Pharmacol Exp Ther; 2009 May 06; 329(2):459-68. PubMed ID: 19223665
    [Abstract] [Full Text] [Related]

  • 7. Distinct profiles of alpha7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes.
    Grønlien JH, Håkerud M, Ween H, Thorin-Hagene K, Briggs CA, Gopalakrishnan M, Malysz J.
    Mol Pharmacol; 2007 Sep 06; 72(3):715-24. PubMed ID: 17565004
    [Abstract] [Full Text] [Related]

  • 8. Molecular dissection of tropisetron, an alpha7 nicotinic acetylcholine receptor-selective partial agonist.
    Papke RL, Schiff HC, Jack BA, Horenstein NA.
    Neurosci Lett; 2005 Apr 22; 378(3):140-4. PubMed ID: 15781147
    [Abstract] [Full Text] [Related]

  • 9. An allosteric modulator of the alpha7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo.
    Timmermann DB, Grønlien JH, Kohlhaas KL, Nielsen EØ, Dam E, Jørgensen TD, Ahring PK, Peters D, Holst D, Christensen JK, Malysz J, Briggs CA, Gopalakrishnan M, Olsen GM.
    J Pharmacol Exp Ther; 2007 Oct 22; 323(1):294-307. PubMed ID: 17625074
    [Abstract] [Full Text] [Related]

  • 10. Effects of the novel α7 nicotinic acetylcholine receptor agonist ABT-107 on sensory gating in DBA/2 mice: pharmacodynamic characterization.
    Radek RJ, Robb HM, Stevens KE, Gopalakrishnan M, Bitner RS.
    J Pharmacol Exp Ther; 2012 Dec 22; 343(3):736-45. PubMed ID: 22988063
    [Abstract] [Full Text] [Related]

  • 11. Alpha7 nAChR-mediated activation of MAP kinase pathways in PC12 cells.
    Gubbins EJ, Gopalakrishnan M, Li J.
    Brain Res; 2010 Apr 30; 1328():1-11. PubMed ID: 20211606
    [Abstract] [Full Text] [Related]

  • 12. (S)-3-methyl-5-(1-methyl-2-pyrrolidinyl) isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: I. In vitro characterization.
    Arneric SP, Sullivan JP, Briggs CA, Donnelly-Roberts D, Anderson DJ, Raszkiewicz JL, Hughes ML, Cadman ED, Adams P, Garvey DS.
    J Pharmacol Exp Ther; 1994 Jul 30; 270(1):310-8. PubMed ID: 7518514
    [Abstract] [Full Text] [Related]

  • 13. Importance of M2-M3 loop in governing properties of genistein at the α7 nicotinic acetylcholine receptor inferred from α7/5-HT3A chimera.
    Grønlien JH, Ween H, Thorin-Hagene K, Cassar S, Li J, Briggs CA, Gopalakrishnan M, Malysz J.
    Eur J Pharmacol; 2010 Nov 25; 647(1-3):37-47. PubMed ID: 20816816
    [Abstract] [Full Text] [Related]

  • 14. Local and global calcium signals associated with the opening of neuronal alpha7 nicotinic acetylcholine receptors.
    Gilbert D, Lecchi M, Arnaudeau S, Bertrand D, Demaurex N.
    Cell Calcium; 2009 Feb 25; 45(2):198-207. PubMed ID: 19038445
    [Abstract] [Full Text] [Related]

  • 15. Selective alpha7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes.
    Sydserff S, Sutton EJ, Song D, Quirk MC, Maciag C, Li C, Jonak G, Gurley D, Gordon JC, Christian EP, Doherty JJ, Hudzik T, Johnson E, Mrzljak L, Piser T, Smagin GN, Wang Y, Widzowski D, Smith JS.
    Biochem Pharmacol; 2009 Oct 01; 78(7):880-8. PubMed ID: 19615981
    [Abstract] [Full Text] [Related]

  • 16. Differential coupling of alpha7 and non-alpha7 nicotinic acetylcholine receptors to calcium-induced calcium release and voltage-operated calcium channels in PC12 cells.
    Dickinson JA, Hanrott KE, Mok MH, Kew JN, Wonnacott S.
    J Neurochem; 2007 Feb 01; 100(4):1089-96. PubMed ID: 17181555
    [Abstract] [Full Text] [Related]

  • 17. Identification and in vitro pharmacological characterization of a novel and selective α7 nicotinic acetylcholine receptor agonist, Br-IQ17B.
    Tang JS, Xie BX, Bian XL, Xue Y, Wei NN, Zhou JH, Hao YC, Li G, Zhang LR, Wang KW.
    Acta Pharmacol Sin; 2015 Jul 01; 36(7):800-12. PubMed ID: 25948478
    [Abstract] [Full Text] [Related]

  • 18. Presynaptic alpha 7- and beta 2-containing nicotinic acetylcholine receptors modulate excitatory amino acid release from rat prefrontal cortex nerve terminals via distinct cellular mechanisms.
    Dickinson JA, Kew JN, Wonnacott S.
    Mol Pharmacol; 2008 Aug 01; 74(2):348-59. PubMed ID: 18445710
    [Abstract] [Full Text] [Related]

  • 19. A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization.
    Hurst RS, Hajós M, Raggenbass M, Wall TM, Higdon NR, Lawson JA, Rutherford-Root KL, Berkenpas MB, Hoffmann WE, Piotrowski DW, Groppi VE, Allaman G, Ogier R, Bertrand S, Bertrand D, Arneric SP.
    J Neurosci; 2005 Apr 27; 25(17):4396-405. PubMed ID: 15858066
    [Abstract] [Full Text] [Related]

  • 20. [3H]A-585539 [(1S,4S)-2,2-dimethyl-5-(6-phenylpyridazin-3-yl)-5-aza-2-azoniabicyclo[2.2.1]heptane], a novel high-affinity alpha7 neuronal nicotinic receptor agonist: radioligand binding characterization to rat and human brain.
    Anderson DJ, Bunnelle W, Surber B, Du J, Surowy C, Tribollet E, Marguerat A, Bertrand D, Gopalakrishnan M.
    J Pharmacol Exp Ther; 2008 Jan 27; 324(1):179-87. PubMed ID: 17959745
    [Abstract] [Full Text] [Related]

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