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Pubmed for Handhelds

PUBMED FOR HANDHELDS

Journal Abstract Search

135 related items for PubMed ID: 20507089

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  • 4. NADPH-dependent covalent binding of [3H]paroxetine to human liver microsomes and S-9 fractions: identification of an electrophilic quinone metabolite of paroxetine.
    Zhao SX, Dalvie DK, Kelly JM, Soglia JR, Frederick KS, Smith EB, Obach RS, Kalgutkar AS.
    Chem Res Toxicol; 2007 Nov; 20(11):1649-57. PubMed ID: 17907785
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  • 5. Novel and potent calcium-sensing receptor antagonists: discovery of (5R)-N-[1-ethyl-1-(4-ethylphenyl)propyl]-2,7,7-trimethyl-5-phenyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide monotosylate (TAK-075) as an orally active bone anabolic agent.
    Yoshida M, Mori A, Morimoto S, Kotani E, Oka M, Notoya K, Makino H, Ono M, Shirasaki M, Tada N, Fujita H, Ban J, Ikeda Y, Kawamoto T, Goto M, Kimura H, Baba A, Yasuma T.
    Bioorg Med Chem; 2011 Mar 15; 19(6):1881-94. PubMed ID: 21353570
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  • 6. Structural alert/reactive metabolite concept as applied in medicinal chemistry to mitigate the risk of idiosyncratic drug toxicity: a perspective based on the critical examination of trends in the top 200 drugs marketed in the United States.
    Stepan AF, Walker DP, Bauman J, Price DA, Baillie TA, Kalgutkar AS, Aleo MD.
    Chem Res Toxicol; 2011 Sep 19; 24(9):1345-410. PubMed ID: 21702456
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  • 7. A rational chemical intervention strategy to circumvent bioactivation liabilities associated with a nonpeptidyl thrombopoietin receptor agonist containing a 2-amino-4-arylthiazole motif.
    Kalgutkar AS, Driscoll J, Zhao SX, Walker GS, Shepard RM, Soglia JR, Atherton J, Yu L, Mutlib AE, Munchhof MJ, Reiter LA, Jones CS, Doty JL, Trevena KA, Shaffer CL, Ripp SL.
    Chem Res Toxicol; 2007 Dec 19; 20(12):1954-65. PubMed ID: 17935300
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  • 17. Final report on the safety assessment of capsicum annuum extract, capsicum annuum fruit extract, capsicum annuum resin, capsicum annuum fruit powder, capsicum frutescens fruit, capsicum frutescens fruit extract, capsicum frutescens resin, and capsaicin.
    Int J Toxicol; 2007 Dec 19; 26 Suppl 1():3-106. PubMed ID: 17365137
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  • 20. 3H-Quinazolin-4-ones as a new calcilytic template for the potential treatment of osteoporosis.
    Shcherbakova I, Balandrin MF, Fox J, Ghatak A, Heaton WL, Conklin RL.
    Bioorg Med Chem Lett; 2005 Mar 15; 15(6):1557-60. PubMed ID: 15745796
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