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Journal Abstract Search

507 related items for PubMed ID: 20516278

  • 1. PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication.
    Lam AM, Murakami E, Espiritu C, Steuer HM, Niu C, Keilman M, Bao H, Zennou V, Bourne N, Julander JG, Morrey JD, Smee DF, Frick DN, Heck JA, Wang P, Nagarathnam D, Ross BS, Sofia MJ, Otto MJ, Furman PA.
    Antimicrob Agents Chemother; 2010 Aug; 54(8):3187-96. PubMed ID: 20516278
    [Abstract] [Full Text] [Related]

  • 2. Activity and the metabolic activation pathway of the potent and selective hepatitis C virus pronucleotide inhibitor PSI-353661.
    Furman PA, Murakami E, Niu C, Lam AM, Espiritu C, Bansal S, Bao H, Tolstykh T, Micolochick Steuer H, Keilman M, Zennou V, Bourne N, Veselenak RL, Chang W, Ross BS, Du J, Otto MJ, Sofia MJ.
    Antiviral Res; 2011 Aug; 91(2):120-32. PubMed ID: 21600932
    [Abstract] [Full Text] [Related]

  • 3. Inhibition of hepatitis C virus replicon RNA synthesis by PSI-352938, a cyclic phosphate prodrug of β-D-2'-deoxy-2'-α-fluoro-2'-β-C-methylguanosine.
    Lam AM, Espiritu C, Murakami E, Zennou V, Bansal S, Micolochick Steuer HM, Niu C, Keilman M, Bao H, Bourne N, Veselenak RL, Reddy PG, Chang W, Du J, Nagarathnam D, Sofia MJ, Otto MJ, Furman PA.
    Antimicrob Agents Chemother; 2011 Jun; 55(6):2566-75. PubMed ID: 21444700
    [Abstract] [Full Text] [Related]

  • 4. Hepatitis C virus nucleotide inhibitors PSI-352938 and PSI-353661 exhibit a novel mechanism of resistance requiring multiple mutations within replicon RNA.
    Lam AM, Espiritu C, Bansal S, Micolochick Steuer HM, Zennou V, Otto MJ, Furman PA.
    J Virol; 2011 Dec; 85(23):12334-42. PubMed ID: 21957306
    [Abstract] [Full Text] [Related]

  • 5. Selected replicon variants with low-level in vitro resistance to the hepatitis C virus NS5B polymerase inhibitor PSI-6130 lack cross-resistance with R1479.
    Ali S, Leveque V, Le Pogam S, Ma H, Philipp F, Inocencio N, Smith M, Alker A, Kang H, Najera I, Klumpp K, Symons J, Cammack N, Jiang WR.
    Antimicrob Agents Chemother; 2008 Dec; 52(12):4356-69. PubMed ID: 18838588
    [Abstract] [Full Text] [Related]

  • 6. Resistance analysis and characterization of NITD008 as an adenosine analog inhibitor against hepatitis C virus.
    Qing J, Luo R, Wang Y, Nong J, Wu M, Shao Y, Tang R, Yu X, Yin Z, Sun Y.
    Antiviral Res; 2016 Feb; 126():43-54. PubMed ID: 26724382
    [Abstract] [Full Text] [Related]

  • 7. Mechanism of activation of beta-D-2'-deoxy-2'-fluoro-2'-c-methylcytidine and inhibition of hepatitis C virus NS5B RNA polymerase.
    Murakami E, Bao H, Ramesh M, McBrayer TR, Whitaker T, Micolochick Steuer HM, Schinazi RF, Stuyver LJ, Obikhod A, Otto MJ, Furman PA.
    Antimicrob Agents Chemother; 2007 Feb; 51(2):503-9. PubMed ID: 17101674
    [Abstract] [Full Text] [Related]

  • 8. 2'-deoxy-4'-azido nucleoside analogs are highly potent inhibitors of hepatitis C virus replication despite the lack of 2'-alpha-hydroxyl groups.
    Klumpp K, Kalayanov G, Ma H, Le Pogam S, Leveque V, Jiang WR, Inocencio N, De Witte A, Rajyaguru S, Tai E, Chanda S, Irwin MR, Sund C, Winqist A, Maltseva T, Eriksson S, Usova E, Smith M, Alker A, Najera I, Cammack N, Martin JA, Johansson NG, Smith DB.
    J Biol Chem; 2008 Jan 25; 283(4):2167-75. PubMed ID: 18003608
    [Abstract] [Full Text] [Related]

  • 9. Inhibition of hepatitis C virus replication by GS-6620, a potent C-nucleoside monophosphate prodrug.
    Feng JY, Cheng G, Perry J, Barauskas O, Xu Y, Fenaux M, Eng S, Tirunagari N, Peng B, Yu M, Tian Y, Lee YJ, Stepan G, Lagpacan LL, Jin D, Hung M, Ku KS, Han B, Kitrinos K, Perron M, Birkus G, Wong KA, Zhong W, Kim CU, Carey A, Cho A, Ray AS.
    Antimicrob Agents Chemother; 2014 Jan 25; 58(4):1930-42. PubMed ID: 24419349
    [Abstract] [Full Text] [Related]

  • 10. Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus.
    Lam AM, Espiritu C, Bansal S, Micolochick Steuer HM, Niu C, Zennou V, Keilman M, Zhu Y, Lan S, Otto MJ, Furman PA.
    Antimicrob Agents Chemother; 2012 Jun 25; 56(6):3359-68. PubMed ID: 22430955
    [Abstract] [Full Text] [Related]

  • 11. The novel nucleoside analog R1479 (4'-azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture.
    Klumpp K, Lévêque V, Le Pogam S, Ma H, Jiang WR, Kang H, Granycome C, Singer M, Laxton C, Hang JQ, Sarma K, Smith DB, Heindl D, Hobbs CJ, Merrett JH, Symons J, Cammack N, Martin JA, Devos R, Nájera I.
    J Biol Chem; 2006 Feb 17; 281(7):3793-9. PubMed ID: 16316989
    [Abstract] [Full Text] [Related]

  • 12. Inhibition of hepatitis C replicon RNA synthesis by beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine: a specific inhibitor of hepatitis C virus replication.
    Stuyver LJ, McBrayer TR, Tharnish PM, Clark J, Hollecker L, Lostia S, Nachman T, Grier J, Bennett MA, Xie MY, Schinazi RF, Morrey JD, Julander JL, Furman PA, Otto MJ.
    Antivir Chem Chemother; 2006 Feb 17; 17(2):79-87. PubMed ID: 17042329
    [Abstract] [Full Text] [Related]

  • 13. Preclinical characterization of BMS-791325, an allosteric inhibitor of hepatitis C Virus NS5B polymerase.
    Lemm JA, Liu M, Gentles RG, Ding M, Voss S, Pelosi LA, Wang YK, Rigat KL, Mosure KW, Bender JA, Knipe JO, Colonno R, Meanwell NA, Kadow JF, Santone KS, Roberts SB, Gao M.
    Antimicrob Agents Chemother; 2014 Jun 17; 58(6):3485-95. PubMed ID: 24733465
    [Abstract] [Full Text] [Related]

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  • 15. HCV NS5A replication complex inhibitors. Part 4. Optimization for genotype 1a replicon inhibitory activity.
    St Laurent DR, Serrano-Wu MH, Belema M, Ding M, Fang H, Gao M, Goodrich JT, Krause RG, Lemm JA, Liu M, Lopez OD, Nguyen VN, Nower PT, O'Boyle DR, Pearce BC, Romine JL, Valera L, Sun JH, Wang YK, Yang F, Yang X, Meanwell NA, Snyder LB.
    J Med Chem; 2014 Mar 13; 57(5):1976-94. PubMed ID: 23573957
    [Abstract] [Full Text] [Related]

  • 16. In vitro characterization of GSK2485852, a novel hepatitis C virus polymerase inhibitor.
    Voitenleitner C, Crosby R, Walker J, Remlinger K, Vamathevan J, Wang A, You S, Johnson J, Woldu E, Van Horn S, Horton J, Creech K, Shotwell JB, Hong Z, Hamatake R.
    Antimicrob Agents Chemother; 2013 Nov 13; 57(11):5216-24. PubMed ID: 23939896
    [Abstract] [Full Text] [Related]

  • 17. A 2'-deoxy-2'-fluoro-2'-C-methyl uridine cyclopentyl carbocyclic analog and its phosphoramidate prodrug as inhibitors of HCV NS5B polymerase.
    Liu J, Du J, Wang P, Nagarathnam D, Espiritu CL, Bao H, Murakami E, Furman PA, Sofia MJ.
    Nucleosides Nucleotides Nucleic Acids; 2012 Apr 13; 31(4):277-85. PubMed ID: 22444190
    [Abstract] [Full Text] [Related]

  • 18. Novel nonnucleoside inhibitor of hepatitis C virus RNA-dependent RNA polymerase.
    Howe AY, Bloom J, Baldick CJ, Benetatos CA, Cheng H, Christensen JS, Chunduru SK, Coburn GA, Feld B, Gopalsamy A, Gorczyca WP, Herrmann S, Johann S, Jiang X, Kimberland ML, Krisnamurthy G, Olson M, Orlowski M, Swanberg S, Thompson I, Thorn M, Del Vecchio A, Young DC, van Zeijl M, Ellingboe JW, Upeslacis J, Collett M, Mansour TS, O'Connell JF.
    Antimicrob Agents Chemother; 2004 Dec 13; 48(12):4813-21. PubMed ID: 15561861
    [Abstract] [Full Text] [Related]

  • 19. In vitro activity and resistance profile of dasabuvir, a nonnucleoside hepatitis C virus polymerase inhibitor.
    Kati W, Koev G, Irvin M, Beyer J, Liu Y, Krishnan P, Reisch T, Mondal R, Wagner R, Molla A, Maring C, Collins C.
    Antimicrob Agents Chemother; 2015 Mar 13; 59(3):1505-11. PubMed ID: 25534735
    [Abstract] [Full Text] [Related]

  • 20. Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) and identification of a novel active 5'-triphosphate species.
    Ma H, Jiang WR, Robledo N, Leveque V, Ali S, Lara-Jaime T, Masjedizadeh M, Smith DB, Cammack N, Klumpp K, Symons J.
    J Biol Chem; 2007 Oct 12; 282(41):29812-20. PubMed ID: 17698842
    [Abstract] [Full Text] [Related]

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