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Pubmed for Handhelds

PUBMED FOR HANDHELDS

Journal Abstract Search

153 related items for PubMed ID: 20541405

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  • 25. Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization.
    Prongay AJ, Guo Z, Yao N, Pichardo J, Fischmann T, Strickland C, Myers J, Weber PC, Beyer BM, Ingram R, Hong Z, Prosise WW, Ramanathan L, Taremi SS, Yarosh-Tomaine T, Zhang R, Senior M, Yang RS, Malcolm B, Arasappan A, Bennett F, Bogen SL, Chen K, Jao E, Liu YT, Lovey RG, Saksena AK, Venkatraman S, Girijavallabhan V, Njoroge FG, Madison V.
    J Med Chem; 2007 May 17; 50(10):2310-8. PubMed ID: 17444623
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  • 29. The metabolism and disposition of a potent inhibitor of hepatitis C virus NS3/4A protease.
    Monteagudo E, Fonsi M, Chu X, Bleasby K, Evers R, Pucci V, Orsale MV, Cianetti S, Ferrara M, Harper S, Laufer R, Rowley M, Summa V.
    Xenobiotica; 2010 Dec 17; 40(12):826-39. PubMed ID: 20925584
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  • 32. Pyrrolidine-5,5-trans-lactams. 1. Synthesis and incorporation into inhibitors of hepatitis C virus NS3/4A protease.
    Andrews DM, Carey SJ, Chaignot H, Coomber BA, Gray NM, Hind SL, Jones PS, Mills G, Robinson JE, Slater MJ.
    Org Lett; 2002 Dec 12; 4(25):4475-8. PubMed ID: 12465916
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  • 33. Blunting the Swiss army knife of hepatitis C virus: inhibitors of NS3/4A protease.
    White PW, Llinas-Brunet M, Bös M.
    Prog Med Chem; 2006 Dec 12; 44():65-107. PubMed ID: 16697895
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  • 34. Development of a cell-based assay for monitoring hepatitis C virus ns3/4a protease activity.
    Lei YF, Yin W, Yang J, Lv X, Wei SH, An QX, Hu XB, Xu ZK.
    Acta Virol; 2008 Dec 12; 52(3):133-41. PubMed ID: 18999887
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  • 37. Pyrrolidine-5,5-trans-lactams. 4. Incorporation of a P3/P4 urea leads to potent intracellular inhibitors of hepatitis C virus NS3/4A protease.
    Slater MJ, Amphlett EM, Andrews DM, Bamborough P, Carey SJ, Johnson MR, Jones PS, Mills G, Parry NR, Somers DO, Stewart AJ, Skarzynski T.
    Org Lett; 2003 Nov 27; 5(24):4627-30. PubMed ID: 14627400
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  • 38. Synthesis and SAR of acyclic HCV NS3 protease inhibitors with novel P4-benzoxaborole moieties.
    Li X, Zhang S, Zhang YK, Liu Y, Ding CZ, Zhou Y, Plattner JJ, Baker SJ, Bu W, Liu L, Kazmierski WM, Duan M, Grimes RM, Wright LL, Smith GK, Jarvest RL, Ji JJ, Cooper JP, Tallant MD, Crosby RM, Creech K, Ni ZJ, Zou W, Wright J.
    Bioorg Med Chem Lett; 2011 Apr 01; 21(7):2048-54. PubMed ID: 21353550
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  • 39. Design and synthesis of depeptidized macrocyclic inhibitors of hepatitis C NS3-4A protease using structure-based drug design.
    Venkatraman S, Njoroge FG, Girijavallabhan VM, Madison VS, Yao NH, Prongay AJ, Butkiewicz N, Pichardo J.
    J Med Chem; 2005 Aug 11; 48(16):5088-91. PubMed ID: 16078825
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  • 40. NMR structural characterization of peptide inhibitors bound to the Hepatitis C virus NS3 protease: design of a new P2 substituent.
    Goudreau N, Cameron DR, Bonneau P, Gorys V, Plouffe C, Poirier M, Lamarre D, Llinas-Brunet M.
    J Med Chem; 2004 Jan 01; 47(1):123-32. PubMed ID: 14695826
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