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371 related items for PubMed ID: 20590592

  • 1. The xanthine derivative KMUP-1 inhibits models of pulmonary artery hypertension via increased NO and cGMP-dependent inhibition of RhoA/Rho kinase.
    Chung HH, Dai ZK, Wu BN, Yeh JL, Chai CY, Chu KS, Liu CP, Chen IJ.
    Br J Pharmacol; 2010 Jun; 160(4):971-86. PubMed ID: 20590592
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  • 2. Endothelial nitric oxide synthase-enhancing G-protein coupled receptor antagonist inhibits pulmonary artery hypertension by endothelin-1-dependent and endothelin-1-independent pathways in a monocrotaline model.
    Liu CP, Dai ZK, Huang CH, Yeh JL, Wu BN, Wu JR, Chen IJ.
    Kaohsiung J Med Sci; 2014 Jun; 30(6):267-78. PubMed ID: 24835346
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  • 3. Buffered l-ascorbic acid, alone or bound to KMUP-1 or sildenafil, reduces vascular endothelium growth factor and restores endothelium nitric oxide synthase in hypoxic pulmonary artery.
    Wu JR, Kao LP, Wu BN, Dai ZK, Wang YY, Chai CY, Chen IJ.
    Kaohsiung J Med Sci; 2015 May; 31(5):241-54. PubMed ID: 25910559
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  • 4. KMUP-1 inhibits pulmonary artery proliferation by targeting serotonin receptors/transporter and NO synthase, inactivating RhoA and suppressing AKT/ERK phosphorylation.
    Chung HH, Dai ZK, Wu BN, Yeh JL, Chai CY, Chu KS, Liu CP, Chen IJ.
    Vascul Pharmacol; 2010 May; 53(5-6):239-49. PubMed ID: 20870034
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  • 7. KMUP-1 ameliorates monocrotaline-induced pulmonary arterial hypertension through the modulation of Ca2+ sensitization and K+-channel.
    Dai ZK, Cheng YJ, Chung HH, Wu JR, Chen IJ, Wu BN.
    Life Sci; 2010 May 08; 86(19-20):747-55. PubMed ID: 20303989
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  • 8. Sustained therapeutic hypercapnia attenuates pulmonary arterial Rho-kinase activity and ameliorates chronic hypoxic pulmonary hypertension in juvenile rats.
    Peng G, Ivanovska J, Kantores C, Van Vliet T, Engelberts D, Kavanagh BP, Enomoto M, Belik J, Jain A, McNamara PJ, Jankov RP.
    Am J Physiol Heart Circ Physiol; 2012 Jun 15; 302(12):H2599-611. PubMed ID: 22505643
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  • 9. Liraglutide prevents and reverses monocrotaline-induced pulmonary arterial hypertension by suppressing ET-1 and enhancing eNOS/sGC/PKG pathways.
    Lee MY, Tsai KB, Hsu JH, Shin SJ, Wu JR, Yeh JL.
    Sci Rep; 2016 Sep 01; 6():31788. PubMed ID: 27581840
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  • 10. Inhibition of proinflammatory tumor necrosis factor-{alpha}-induced inducible nitric-oxide synthase by xanthine-based 7-[2-[4-(2-chlorobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine (KMUP-1) and 7-[2-[4-(4-nitrobenzene)piperazinyl]ethyl]-1, 3-dimethylxanthine (KMUP-3) in rat trachea: The involvement of soluble guanylate cyclase and protein kinase G.
    Wu BN, Chen CW, Liou SF, Yeh JL, Chung HH, Chen IJ.
    Mol Pharmacol; 2006 Sep 01; 70(3):977-85. PubMed ID: 16754782
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  • 11. cGMP-enhancing- and alpha1A/alpha1D-adrenoceptor blockade-derived inhibition of Rho-kinase by KMUP-1 provides optimal prostate relaxation and epithelial cell anti-proliferation efficacy.
    Liu CM, Lo YC, Wu BN, Wu WJ, Chou YH, Huang CH, An LM, Chen IJ.
    Prostate; 2007 Sep 15; 67(13):1397-410. PubMed ID: 17639498
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  • 17. Inhibition of RhoA/ROCK signaling pathway ameliorates hypoxic pulmonary hypertension via HIF-1α-dependent functional TRPC channels.
    Wang XY, Mo D, Tian W, Liu XX, Zhou YG, Sun Y, Feng YD, Xiao X, Hao XW, Zhang HN, Li C, Cao W, Li XQ.
    Toxicol Appl Pharmacol; 2019 Apr 15; 369():60-72. PubMed ID: 30831131
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  • 19. Cyclic guanosine monophosphate-enhancing reduces androgenic extracellular regulated protein kinases-phosphorylation/Rho kinase II-activation in benign prostate hyperplasia.
    Liu CM, Fan YC, Lo YC, Wu BN, Yeh JL, Chen IJ.
    Int J Urol; 2014 Jan 15; 21(1):87-92. PubMed ID: 23692571
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  • 20. The Xanthine Derivative KMUP-1 Attenuates Serotonin-Induced Vasoconstriction and K⁺-Channel Inhibitory Activity via the PKC Pathway in Pulmonary Arteries.
    Dai ZK, Liu YW, Hsu JH, Yeh JL, Chen IJ, Wu JR, Wu BN.
    Int J Biol Sci; 2015 Jan 15; 11(6):633-42. PubMed ID: 25999786
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