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Journal Abstract Search

230 related items for PubMed ID: 20595376

  • 1. Assessment of a micropatterned hepatocyte coculture system to generate major human excretory and circulating drug metabolites.
    Wang WW, Khetani SR, Krzyzewski S, Duignan DB, Obach RS.
    Drug Metab Dispos; 2010 Oct; 38(10):1900-5. PubMed ID: 20595376
    [Abstract] [Full Text] [Related]

  • 2. Generation of major human excretory and circulating drug metabolites using a hepatocyte relay method.
    Ballard TE, Orozco CC, Obach RS.
    Drug Metab Dispos; 2014 May; 42(5):899-902. PubMed ID: 24608634
    [Abstract] [Full Text] [Related]

  • 3. Assessment of three human in vitro systems in the generation of major human excretory and circulating metabolites.
    Dalvie D, Obach RS, Kang P, Prakash C, Loi CM, Hurst S, Nedderman A, Goulet L, Smith E, Bu HZ, Smith DA.
    Chem Res Toxicol; 2009 Feb; 22(2):357-68. PubMed ID: 19146377
    [Abstract] [Full Text] [Related]

  • 4. Metabolism of prazosin in rat, dog, and human liver microsomes and cryopreserved rat and human hepatocytes and characterization of metabolites by liquid chromatography/tandem mass spectrometry.
    Erve JC, Vashishtha SC, DeMaio W, Talaat RE.
    Drug Metab Dispos; 2007 Jun; 35(6):908-16. PubMed ID: 17353349
    [Abstract] [Full Text] [Related]

  • 5. A new in vitro approach for the simultaneous determination of phase I and phase II enzymatic activities of human hepatocyte preparations.
    Lahoz A, Donato MT, Montero S, Castell JV, Gómez-Lechón MJ.
    Rapid Commun Mass Spectrom; 2008 Jun; 22(2):240-4. PubMed ID: 18088071
    [Abstract] [Full Text] [Related]

  • 6. Low-Turnover Drug Molecules: A Current Challenge for Drug Metabolism Scientists.
    Hutzler JM, Ring BJ, Anderson SR.
    Drug Metab Dispos; 2015 Dec; 43(12):1917-28. PubMed ID: 26363026
    [Abstract] [Full Text] [Related]

  • 7. Studies comparing in vivo:in vitro metabolism of three pharmaceutical compounds in rat, dog, monkey, and human using cryopreserved hepatocytes, microsomes, and collagen gel immobilized hepatocyte cultures.
    Hewitt NJ, Bühring KU, Dasenbrock J, Haunschild J, Ladstetter B, Utesch D.
    Drug Metab Dispos; 2001 Jul; 29(7):1042-50. PubMed ID: 11408372
    [Abstract] [Full Text] [Related]

  • 8. In vitro metabolism of rivaroxaban, an oral, direct factor Xa inhibitor, in liver microsomes and hepatocytes of rats, dogs, and humans.
    Lang D, Freudenberger C, Weinz C.
    Drug Metab Dispos; 2009 May; 37(5):1046-55. PubMed ID: 19196846
    [Abstract] [Full Text] [Related]

  • 9. In vitro evaluation of major in vivo drug metabolic pathways using primary human hepatocytes and HepaRG cells in suspension and a dynamic three-dimensional bioreactor system.
    Darnell M, Ulvestad M, Ellis E, Weidolf L, Andersson TB.
    J Pharmacol Exp Ther; 2012 Oct; 343(1):134-44. PubMed ID: 22776955
    [Abstract] [Full Text] [Related]

  • 10. Use of HμREL Human Coculture System for Prediction of Intrinsic Clearance and Metabolite Formation for Slowly Metabolized Compounds.
    Hultman Ia, Vedin C, Abrahamsson A, Winiwarter S, Darnell M.
    Mol Pharm; 2016 Aug 01; 13(8):2796-807. PubMed ID: 27377099
    [Abstract] [Full Text] [Related]

  • 11. Application of a Micropatterned Cocultured Hepatocyte System To Predict Preclinical and Human-Specific Drug Metabolism.
    Ballard TE, Wang S, Cox LM, Moen MA, Krzyzewski S, Ukairo O, Obach RS.
    Drug Metab Dispos; 2016 Feb 01; 44(2):172-9. PubMed ID: 26608083
    [Abstract] [Full Text] [Related]

  • 12. Transport, metabolism, and hepatotoxicity of flutamide, drug-drug interaction with acetaminophen involving phase I and phase II metabolites.
    Kostrubsky SE, Strom SC, Ellis E, Nelson SD, Mutlib AE.
    Chem Res Toxicol; 2007 Oct 01; 20(10):1503-12. PubMed ID: 17900172
    [Abstract] [Full Text] [Related]

  • 13. Evaluation of fresh and cryopreserved hepatocytes as in vitro drug metabolism tools for the prediction of metabolic clearance.
    McGinnity DF, Soars MG, Urbanowicz RA, Riley RJ.
    Drug Metab Dispos; 2004 Nov 01; 32(11):1247-53. PubMed ID: 15286053
    [Abstract] [Full Text] [Related]

  • 14. Micropatterned coculture of hepatocytes on electrospun fibers as a potential in vitro model for predictive drug metabolism.
    Liu Y, Wei J, Lu J, Lei D, Yan S, Li X.
    Mater Sci Eng C Mater Biol Appl; 2016 Jun 01; 63():475-84. PubMed ID: 27040241
    [Abstract] [Full Text] [Related]

  • 15. Human hepatocytes: isolation, cryopreservation and applications in drug development.
    Li AP.
    Chem Biol Interact; 2007 May 20; 168(1):16-29. PubMed ID: 17270162
    [Abstract] [Full Text] [Related]

  • 16. Hepatocytes--the choice to investigate drug metabolism and toxicity in man: in vitro variability as a reflection of in vivo.
    Gómez-Lechón MJ, Castell JV, Donato MT.
    Chem Biol Interact; 2007 May 20; 168(1):30-50. PubMed ID: 17134688
    [Abstract] [Full Text] [Related]

  • 17. Characterization of the in vitro metabolic profile of amlodipine in rat using liquid chromatography-mass spectrometry.
    Suchanova B, Kostiainen R, Ketola RA.
    Eur J Pharm Sci; 2008 Jan 20; 33(1):91-9. PubMed ID: 18055188
    [Abstract] [Full Text] [Related]

  • 18. From known knowns to known unknowns: predicting in vivo drug metabolites.
    Pelkonen O, Tolonen A, Korjamo T, Turpeinen M, Raunio H.
    Bioanalysis; 2009 May 20; 1(2):393-414. PubMed ID: 21083174
    [Abstract] [Full Text] [Related]

  • 19. Predicting circulating human metabolites: how good are we?
    Anderson S, Luffer-Atlas D, Knadler MP.
    Chem Res Toxicol; 2009 Feb 20; 22(2):243-56. PubMed ID: 19138063
    [Abstract] [Full Text] [Related]

  • 20. Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data.
    Jones HM, Barton HA, Lai Y, Bi YA, Kimoto E, Kempshall S, Tate SC, El-Kattan A, Houston JB, Galetin A, Fenner KS.
    Drug Metab Dispos; 2012 May 20; 40(5):1007-17. PubMed ID: 22344703
    [Abstract] [Full Text] [Related]

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