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163 related items for PubMed ID: 20606319

  • 1. Inhibition of tumor progression locus 2 protein kinase decreases lipopolysaccharide-induced tumor necrosis factor alpha production due to the inhibition of the tip-associated protein induction in RAW264.7 cells.
    Hirata K, Miyashiro M, Ogawa H, Taki H, Tobe K, Sugita T.
    Biol Pharm Bull; 2010; 33(7):1233-7. PubMed ID: 20606319
    [Abstract] [Full Text] [Related]

  • 2. Sensitivity of TLR4- and -7-induced NF kappa B1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages.
    Loniewski KJ, Patial S, Parameswaran N.
    Mol Immunol; 2007 Jul; 44(15):3715-23. PubMed ID: 17507094
    [Abstract] [Full Text] [Related]

  • 3. [Synergetic effect of mitogen-activated protein kinase pathway on expression of tumor necrosis factor alpha gene in RAW 264.7 cells induced by lipopolysaccharide].
    Jiang Y, Liu A, Qin Q, Yin Z.
    Zhonghua Yi Xue Za Zhi; 2002 Oct 25; 82(20):1410-4. PubMed ID: 12509925
    [Abstract] [Full Text] [Related]

  • 4. Inhibitors of tumor progression loci-2 (Tpl2) kinase and tumor necrosis factor alpha (TNF-alpha) production: selectivity and in vivo antiinflammatory activity of novel 8-substituted-4-anilino-6-aminoquinoline-3-carbonitriles.
    Green N, Hu Y, Janz K, Li HQ, Kaila N, Guler S, Thomason J, Joseph-McCarthy D, Tam SY, Hotchandani R, Wu J, Huang A, Wang Q, Leung L, Pelker J, Marusic S, Hsu S, Telliez JB, Hall JP, Cuozzo JW, Lin LL.
    J Med Chem; 2007 Sep 20; 50(19):4728-45. PubMed ID: 17715908
    [Abstract] [Full Text] [Related]

  • 5. Inhibition of tumor progression locus 2 protein kinase suppresses receptor activator of nuclear factor-kappaB ligand-induced osteoclastogenesis through down-regulation of the c-Fos and nuclear factor of activated T cells c1 genes.
    Hirata K, Taki H, Shinoda K, Hounoki H, Miyahara T, Tobe K, Ogawa H, Mori H, Sugiyama E.
    Biol Pharm Bull; 2010 Sep 20; 33(1):133-7. PubMed ID: 20045951
    [Abstract] [Full Text] [Related]

  • 6. The Tpl2 Kinase Regulates the COX-2/Prostaglandin E2 Axis in Adipocytes in Inflammatory Conditions.
    Berthou F, Ceppo F, Dumas K, Massa F, Vergoni B, Alemany S, Cormont M, Tanti JF.
    Mol Endocrinol; 2015 Jul 20; 29(7):1025-36. PubMed ID: 26020725
    [Abstract] [Full Text] [Related]

  • 7. Luteolin, a novel natural inhibitor of tumor progression locus 2 serine/threonine kinase, inhibits tumor necrosis factor-alpha-induced cyclooxygenase-2 expression in JB6 mouse epidermis cells.
    Kim JE, Son JE, Jang YJ, Lee DE, Kang NJ, Jung SK, Heo YS, Lee KW, Lee HJ.
    J Pharmacol Exp Ther; 2011 Sep 20; 338(3):1013-22. PubMed ID: 21705614
    [Abstract] [Full Text] [Related]

  • 8. The p38 MAPK inhibitor JLU1124 inhibits the inflammatory response induced by lipopolysaccharide through the MAPK-NF-κB pathway in RAW264.7 macrophages.
    Li XN, Su J, Zhao L, Xiang JB, Wang W, Liu F, Li HY, Zhong JT, Bai X, Sun LK.
    Int Immunopharmacol; 2013 Nov 20; 17(3):785-92. PubMed ID: 24070708
    [Abstract] [Full Text] [Related]

  • 9. Tpl2 (tumor progression locus 2) phosphorylation at Thr290 is induced by lipopolysaccharide via an Ikappa-B Kinase-beta-dependent pathway and is required for Tpl2 activation by external signals.
    Cho J, Melnick M, Solidakis GP, Tsichlis PN.
    J Biol Chem; 2005 May 27; 280(21):20442-8. PubMed ID: 15778223
    [Abstract] [Full Text] [Related]

  • 10. Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood.
    Hall JP, Kurdi Y, Hsu S, Cuozzo J, Liu J, Telliez JB, Seidl KJ, Winkler A, Hu Y, Green N, Askew GR, Tam S, Clark JD, Lin LL.
    J Biol Chem; 2007 Nov 16; 282(46):33295-33304. PubMed ID: 17848581
    [Abstract] [Full Text] [Related]

  • 11. TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway.
    Dumitru CD, Ceci JD, Tsatsanis C, Kontoyiannis D, Stamatakis K, Lin JH, Patriotis C, Jenkins NA, Copeland NG, Kollias G, Tsichlis PN.
    Cell; 2000 Dec 22; 103(7):1071-83. PubMed ID: 11163183
    [Abstract] [Full Text] [Related]

  • 12. Tumor progression locus 2-dependent oxidative burst drives phosphorylation of extracellular signal-regulated kinase during TLR3 and 9 signaling.
    Kuriakose T, Rada B, Watford WT.
    J Biol Chem; 2014 Dec 26; 289(52):36089-100. PubMed ID: 25378393
    [Abstract] [Full Text] [Related]

  • 13. Acetaminophen and lipopolysaccharide act in synergy for the production of pro-inflammatory cytokines in murine RAW264.7 macrophages.
    Lacour S, Antonios D, Gautier JC, Pallardy M.
    J Immunotoxicol; 2009 Jun 26; 6(2):84-93. PubMed ID: 19589095
    [Abstract] [Full Text] [Related]

  • 14. Nonparticipation of nuclear factor kappa B (NFkappaB) in the signaling cascade of c-Jun N-terminal kinase (JNK)- and p38 mitogen-activated protein kinase (p38MAPK)-dependent tumor necrosis factor alpha (TNFalpha) induction in lipopolysaccharide (LPS)-stimulated microglia.
    Uesugi M, Nakajima K, Tohyama Y, Kohsaka S, Kurihara T.
    Brain Res; 2006 Feb 16; 1073-1074():48-59. PubMed ID: 16457791
    [Abstract] [Full Text] [Related]

  • 15. Stress-induced phosphorylation of STAT1 at Ser727 requires p38 mitogen-activated protein kinase whereas IFN-gamma uses a different signaling pathway.
    Kovarik P, Stoiber D, Eyers PA, Menghini R, Neininger A, Gaestel M, Cohen P, Decker T.
    Proc Natl Acad Sci U S A; 1999 Nov 23; 96(24):13956-61. PubMed ID: 10570180
    [Abstract] [Full Text] [Related]

  • 16. The role of tumor progression locus 2 protein kinase in glial inflammatory response.
    Hirschhorn J, Mohanty S, Bhat NR.
    J Neurochem; 2014 Mar 23; 128(6):919-26. PubMed ID: 24188160
    [Abstract] [Full Text] [Related]

  • 17. TPL2 Is a Key Regulator of Intestinal Inflammation in Clostridium difficile Infection.
    Wang Y, Wang S, Kelly CP, Feng H, Greenberg A, Sun X.
    Infect Immun; 2018 Aug 23; 86(8):. PubMed ID: 29844241
    [Abstract] [Full Text] [Related]

  • 18. Inhibition of TPL2 by interferon-α suppresses bladder cancer through activation of PDE4D.
    Qiang Z, Zhou ZY, Peng T, Jiang PZ, Shi N, Njoya EM, Azimova B, Liu WL, Chen WH, Zhang GL, Wang F.
    J Exp Clin Cancer Res; 2018 Nov 27; 37(1):288. PubMed ID: 30482227
    [Abstract] [Full Text] [Related]

  • 19. Effects of Ginkgo biloba extract (EGb 761) and quercetin on lipopolysaccharide-induced signaling pathways involved in the release of tumor necrosis factor-alpha.
    Wadsworth TL, McDonald TL, Koop DR.
    Biochem Pharmacol; 2001 Oct 01; 62(7):963-74. PubMed ID: 11543732
    [Abstract] [Full Text] [Related]

  • 20. Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase.
    Feng GJ, Goodridge HS, Harnett MM, Wei XQ, Nikolaev AV, Higson AP, Liew FY.
    J Immunol; 1999 Dec 15; 163(12):6403-12. PubMed ID: 10586030
    [Abstract] [Full Text] [Related]

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