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Journal Abstract Search

147 related items for PubMed ID: 2066994

  • 1. Quinazoline antifolate thymidylate synthase inhibitors: bridge modifications and conformationally restricted analogues in the C2-methyl series.
    Marsham PR, Jackman AL, Hayter AJ, Daw MR, Snowden JL, O'Connor BM, Bishop JA, Calvert AH, Hughes LR.
    J Med Chem; 1991 Jul; 34(7):2209-18. PubMed ID: 2066994
    [Abstract] [Full Text] [Related]

  • 2. Quinazoline antifolate thymidylate synthase inhibitors: nitrogen, oxygen, sulfur, and chlorine substituents in the C2 position.
    Marsham PR, Chambers P, Hayter AJ, Hughes LR, Jackman AL, O'Connor BM, Bishop JA, Calvert AH.
    J Med Chem; 1989 Mar; 32(3):569-75. PubMed ID: 2918503
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  • 3. Quinazoline antifolate thymidylate synthase inhibitors: difluoro-substituted benzene ring analogues.
    Thornton TJ, Jackman AL, Marsham PR, O'Connor BM, Bishop JA, Calvert AH.
    J Med Chem; 1992 Jun 12; 35(12):2321-7. PubMed ID: 1613755
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  • 4. Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C2 position.
    Hughes LR, Jackman AL, Oldfield J, Smith RC, Burrows KD, Marsham PR, Bishop JA, Jones TR, O'Connor BM, Calvert AH.
    J Med Chem; 1990 Nov 12; 33(11):3060-7. PubMed ID: 2231606
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  • 5. Quinazoline antifolate thymidylate synthase inhibitors: heterocyclic benzoyl ring modifications.
    Marsham PR, Hughes LR, Jackman AL, Hayter AJ, Oldfield J, Wardleworth JM, Bishop JA, O'Connor BM, Calvert AH.
    J Med Chem; 1991 May 12; 34(5):1594-605. PubMed ID: 2033585
    [Abstract] [Full Text] [Related]

  • 6. Quinazoline antifolate thymidylate synthase inhibitors: replacement of glutamic acid in the C2-methyl series.
    Marsham PR, Jackman AL, Barker AJ, Boyle FT, Pegg SJ, Wardleworth JM, Kimbell R, O'Connor BM, Calvert AH, Hughes LR.
    J Med Chem; 1995 Mar 17; 38(6):994-1004. PubMed ID: 7699716
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  • 7. Quinazoline antifolate thymidylate synthase inhibitors: benzoyl ring modifications in the C2-methyl series.
    Marsham PR, Jackman AL, Oldfield J, Hughes LR, Thornton TJ, Bisset GM, O'Connor BM, Bishop JA, Calvert AH.
    J Med Chem; 1990 Nov 17; 33(11):3072-8. PubMed ID: 2231608
    [Abstract] [Full Text] [Related]

  • 8. Quinazoline antifolate thymidylate synthase inhibitors: 2'-fluoro-N10-propargyl-5,8-dideazafolic acid and derivatives with modifications in the C2 position.
    Jackman AL, Marsham PR, Thornton TJ, Bishop JA, O'Connor BM, Hughes LR, Calvert AH, Jones TR.
    J Med Chem; 1990 Nov 17; 33(11):3067-71. PubMed ID: 2231607
    [Abstract] [Full Text] [Related]

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  • 11. Quinoline antifolate thymidylate synthase inhibitors: variation of the C2- and C4-substituents.
    Warner P, Barker AJ, Jackman AL, Burrows KD, Roberts N, Bishop JA, O'Connor BM, Hughes LR.
    J Med Chem; 1992 Jul 24; 35(15):2761-8. PubMed ID: 1495009
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  • 12. Quinazoline antifolates inhibiting thymidylate synthase: variation of the amino acid.
    Jones TR, Smithers MJ, Betteridge RF, Taylor MA, Jackman AL, Calvert AH, Davies LC, Harrap KR.
    J Med Chem; 1986 Jun 24; 29(6):1114-8. PubMed ID: 3712376
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  • 13. Quinazoline antifolates inhibiting thymidylate synthase: 2-desamino derivatives with enhanced solubility and potency.
    Jones TR, Thornton TJ, Flinn A, Jackman AL, Newell DR, Calvert AH.
    J Med Chem; 1989 Apr 24; 32(4):847-52. PubMed ID: 2704030
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  • 14. Quinazoline antifolates inhibiting thymidylate synthase: computer modelling of the N10 substituent.
    Jones TR, Betteridge RF, Neidle S, Jackman AL, Calvert AH.
    Anticancer Drug Des; 1989 Mar 24; 3(4):243-8. PubMed ID: 2930626
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  • 15. Design and synthesis of potent non-polyglutamatable quinazoline antifolate thymidylate synthase inhibitors.
    Marsham PR, Wardleworth JM, Boyle FT, Hennequin LF, Kimbell R, Brown M, Jackman AL.
    J Med Chem; 1999 Sep 23; 42(19):3809-20. PubMed ID: 10508430
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  • 18. Quinazoline antifolates inhibiting thymidylate synthase: variation of the N10 substituent.
    Jones TR, Calvert AH, Jackman AL, Eakin MA, Smithers MJ, Betteridge RF, Newell DR, Hayter AJ, Stocker A, Harland SJ.
    J Med Chem; 1985 Oct 23; 28(10):1468-76. PubMed ID: 4045922
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