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Journal Abstract Search

123 related items for PubMed ID: 20669986

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  • 4. Cytochrome P450 oxidation of the thiophene-containing anticancer drug 3-[(quinolin-4-ylmethyl)-amino]-thiophene-2-carboxylic acid (4-trifluoromethoxy-phenyl)-amide to an electrophilic intermediate.
    Medower C, Wen L, Johnson WW.
    Chem Res Toxicol; 2008 Aug; 21(8):1570-7. PubMed ID: 18672911
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  • 5. Investigation of bioactivation of ticlopidine using linear ion trap/orbitrap mass spectrometry and an improved mass defect filtering technique.
    Ruan Q, Zhu M.
    Chem Res Toxicol; 2010 May 17; 23(5):909-17. PubMed ID: 20297803
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  • 8. Identification of the thiophene ring of methapyrilene as a novel bioactivation-dependent hepatic toxicophore.
    Graham EE, Walsh RJ, Hirst CM, Maggs JL, Martin S, Wild MJ, Wilson ID, Harding JR, Kenna JG, Peter RM, Williams DP, Park BK.
    J Pharmacol Exp Ther; 2008 Aug 17; 326(2):657-71. PubMed ID: 18451316
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  • 9. Characterization of novel dihydrothienopyridinium and thienopyridinium metabolites of ticlopidine in vitro: role of peroxidases, cytochromes p450, and monoamine oxidases.
    Dalvie DK, O'Connell TN.
    Drug Metab Dispos; 2004 Jan 17; 32(1):49-57. PubMed ID: 14709620
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  • 11. Metabolism and bioactivation of 3-methylindole by human liver microsomes.
    Yan Z, Easterwood LM, Maher N, Torres R, Huebert N, Yost GS.
    Chem Res Toxicol; 2007 Jan 17; 20(1):140-8. PubMed ID: 17226936
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  • 12. A rational chemical intervention strategy to circumvent bioactivation liabilities associated with a nonpeptidyl thrombopoietin receptor agonist containing a 2-amino-4-arylthiazole motif.
    Kalgutkar AS, Driscoll J, Zhao SX, Walker GS, Shepard RM, Soglia JR, Atherton J, Yu L, Mutlib AE, Munchhof MJ, Reiter LA, Jones CS, Doty JL, Trevena KA, Shaffer CL, Ripp SL.
    Chem Res Toxicol; 2007 Dec 17; 20(12):1954-65. PubMed ID: 17935300
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  • 16. Metabolic activation of the phenothiazine antipsychotics chlorpromazine and thioridazine to electrophilic iminoquinone species in human liver microsomes and recombinant P450s.
    Wen B, Zhou M.
    Chem Biol Interact; 2009 Oct 07; 181(2):220-6. PubMed ID: 19482014
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  • 19. Role of human glutathione S-transferases in the inactivation of reactive metabolites of clozapine.
    Dragovic S, Boerma JS, van Bergen L, Vermeulen NP, Commandeur JN.
    Chem Res Toxicol; 2010 Sep 20; 23(9):1467-76. PubMed ID: 20849150
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