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151 related items for PubMed ID: 20695530

  • 1. Chemical basis for the selectivity of the von Hippel Lindau tumor suppressor pVHL for prolyl-hydroxylated HIF-1alpha.
    Illingworth CJ, Loenarz C, Schofield CJ, Domene C.
    Biochemistry; 2010 Aug 17; 49(32):6936-44. PubMed ID: 20695530
    [Abstract] [Full Text] [Related]

  • 2. Quantifying the Binding Interaction between the Hypoxia-Inducible Transcription Factor and the von Hippel-Lindau Suppressor.
    Domene C, Jorgensen C, Vanommeslaeghe K, Schofield CJ, MacKerell A.
    J Chem Theory Comput; 2015 Aug 11; 11(8):3946-54. PubMed ID: 26574473
    [Abstract] [Full Text] [Related]

  • 3. Proline hydroxylation at different sites in hypoxia-inducible factor 1α modulates its interactions with the von Hippel-Lindau tumor suppressor protein.
    Qian H, Zou Y, Tang Y, Gong Y, Qian Z, Wei G, Zhang Q.
    Phys Chem Chem Phys; 2018 Jul 11; 20(27):18756-18765. PubMed ID: 29961792
    [Abstract] [Full Text] [Related]

  • 4. In silico investigation of PHD-3 specific HIF1-α proline 567 hydroxylation: a new player in the VHL/HIF-1α interaction pathway?
    Minervini G, Masiero A, Moro S, Tosatto SC.
    FEBS Lett; 2013 Sep 17; 587(18):2996-3001. PubMed ID: 23886708
    [Abstract] [Full Text] [Related]

  • 5. Simulation of the mutation F76del on the von Hippel-Lindau tumor suppressor protein: mechanism of the disease and implications for drug development.
    Limaverde-Sousa G, Barreto Ede A, Ferreira CG, Casali-da-Rocha JC.
    Proteins; 2013 Feb 17; 81(2):349-63. PubMed ID: 23011899
    [Abstract] [Full Text] [Related]

  • 6. Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.
    Hon WC, Wilson MI, Harlos K, Claridge TD, Schofield CJ, Pugh CW, Maxwell PH, Ratcliffe PJ, Stuart DI, Jones EY.
    Nature; 2002 Jun 27; 417(6892):975-8. PubMed ID: 12050673
    [Abstract] [Full Text] [Related]

  • 7. Effects of point mutations in pVHL on the binding of HIF-1α.
    Domene C, Illingworth CJ.
    Proteins; 2012 Mar 27; 80(3):733-46. PubMed ID: 22105711
    [Abstract] [Full Text] [Related]

  • 8. Evidence for a stereoelectronic effect in human oxygen sensing.
    Loenarz C, Mecinović J, Chowdhury R, McNeill LA, Flashman E, Schofield CJ.
    Angew Chem Int Ed Engl; 2009 Mar 27; 48(10):1784-7. PubMed ID: 19180614
    [Abstract] [Full Text] [Related]

  • 9. Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing.
    Mole DR, Maxwell PH, Pugh CW, Ratcliffe PJ.
    IUBMB Life; 2001 Jul 27; 52(1-2):43-7. PubMed ID: 11795592
    [Abstract] [Full Text] [Related]

  • 10. HIF-1alpha peptide derivatives with modifications at the hydroxyproline residue as activators of HIF-1alpha.
    Ahn DR, Kim SY, Lee MJ, Yang EG.
    Bioorg Med Chem Lett; 2009 Aug 01; 19(15):4403-5. PubMed ID: 19515556
    [Abstract] [Full Text] [Related]

  • 11. von Hippel-Lindau β-domain-luciferase fusion protein as a bioluminescent hydroxyproline sensor for a hypoxia-inducible factor prolyl hydroxylase assay.
    Hong S, Yum S, Ha NC, Jung Y.
    Anal Biochem; 2010 Dec 15; 407(2):220-5. PubMed ID: 20705044
    [Abstract] [Full Text] [Related]

  • 12. Allosteric effects in the marginally stable von Hippel-Lindau tumor suppressor protein and allostery-based rescue mutant design.
    Liu J, Nussinov R.
    Proc Natl Acad Sci U S A; 2008 Jan 22; 105(3):901-6. PubMed ID: 18195360
    [Abstract] [Full Text] [Related]

  • 13. Hydroxylation-Dependent Interaction of Substrates to the Von Hippel-Lindau Tumor Suppressor Protein (VHL).
    Heir P, Ohh M.
    Methods Mol Biol; 2016 Jan 22; 1458():87-94. PubMed ID: 27581016
    [Abstract] [Full Text] [Related]

  • 14. von Hippel-Lindau protein adjusts oxygen sensing of the FIH asparaginyl hydroxylase.
    Li SH, Chun YS, Lim JH, Huang LE, Park JW.
    Int J Biochem Cell Biol; 2011 May 22; 43(5):795-804. PubMed ID: 21316481
    [Abstract] [Full Text] [Related]

  • 15. Alternative regulation of HIF-1α stability through Phosphorylation on Ser451.
    Han HJ, Saeidi S, Kim SJ, Piao JY, Lim S, Guillen-Quispe YN, Choi BY, Surh YJ.
    Biochem Biophys Res Commun; 2021 Mar 19; 545():150-156. PubMed ID: 33550096
    [Abstract] [Full Text] [Related]

  • 16. Nitric oxide donor, (+/-)-S-nitroso-N-acetylpenicillamine, stabilizes transactive hypoxia-inducible factor-1alpha by inhibiting von Hippel-Lindau recruitment and asparagine hydroxylation.
    Park YK, Ahn DR, Oh M, Lee T, Yang EG, Son M, Park H.
    Mol Pharmacol; 2008 Jul 19; 74(1):236-45. PubMed ID: 18426857
    [Abstract] [Full Text] [Related]

  • 17. Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling.
    Min JH, Yang H, Ivan M, Gertler F, Kaelin WG, Pavletich NP.
    Science; 2002 Jun 07; 296(5574):1886-9. PubMed ID: 12004076
    [Abstract] [Full Text] [Related]

  • 18. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.
    Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ, von Kriegsheim A, Hebestreit HF, Mukherji M, Schofield CJ, Maxwell PH, Pugh CW, Ratcliffe PJ.
    Science; 2001 Apr 20; 292(5516):468-72. PubMed ID: 11292861
    [Abstract] [Full Text] [Related]

  • 19. Homology modeling and molecular dynamics simulation of the HIF2α degradation-related HIF2α-VHL complex.
    Dong X, Su X, Yu J, Liu J, Shi X, Pan Q, Yang J, Chen J, Li L, Cao H.
    J Mol Graph Model; 2017 Jan 20; 71():116-123. PubMed ID: 27902963
    [Abstract] [Full Text] [Related]

  • 20. Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases.
    Chowdhury R, McDonough MA, Mecinović J, Loenarz C, Flashman E, Hewitson KS, Domene C, Schofield CJ.
    Structure; 2009 Jul 15; 17(7):981-9. PubMed ID: 19604478
    [Abstract] [Full Text] [Related]

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