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Journal Abstract Search

184 related items for PubMed ID: 20727958

  • 1. Brain uptake of ketoprofen-lysine prodrug in rats.
    Gynther M, Jalkanen A, Lehtonen M, Forsberg M, Laine K, Ropponen J, Leppänen J, Knuuti J, Rautio J.
    Int J Pharm; 2010 Oct 31; 399(1-2):121-8. PubMed ID: 20727958
    [Abstract] [Full Text] [Related]

  • 2. Large neutral amino acid transporter enables brain drug delivery via prodrugs.
    Gynther M, Laine K, Ropponen J, Leppänen J, Mannila A, Nevalainen T, Savolainen J, Järvinen T, Rautio J.
    J Med Chem; 2008 Feb 28; 51(4):932-6. PubMed ID: 18217702
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  • 3. Large amino acid transporter 1 (LAT1) prodrugs of valproic acid: new prodrug design ideas for central nervous system delivery.
    Peura L, Malmioja K, Laine K, Leppänen J, Gynther M, Isotalo A, Rautio J.
    Mol Pharm; 2011 Oct 03; 8(5):1857-66. PubMed ID: 21770378
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  • 4. L-type amino acid transporter 1 utilizing prodrugs: How to achieve effective brain delivery and low systemic exposure of drugs.
    Puris E, Gynther M, Huttunen J, Petsalo A, Huttunen KM.
    J Control Release; 2017 Sep 10; 261():93-104. PubMed ID: 28662899
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  • 5. Glucose promoiety enables glucose transporter mediated brain uptake of ketoprofen and indomethacin prodrugs in rats.
    Gynther M, Ropponen J, Laine K, Leppänen J, Haapakoski P, Peura L, Järvinen T, Rautio J.
    J Med Chem; 2009 May 28; 52(10):3348-53. PubMed ID: 19402664
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  • 6. Mechanistic Study on the Use of the l-Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets.
    Puris E, Gynther M, de Lange ECM, Auriola S, Hammarlund-Udenaes M, Huttunen KM, Loryan I.
    Mol Pharm; 2019 Jul 01; 16(7):3261-3274. PubMed ID: 31180686
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  • 7. Improved brain delivery of a nonsteroidal anti-inflammatory drug with a synthetic glyceride ester: a preliminary attempt at a CNS drug delivery system for the therapy of Alzheimer's disease.
    Deguchi Y, Hayashi H, Fujii S, Naito T, Yokoyama Y, Yamada S, Kimura R.
    J Drug Target; 2000 Jul 01; 8(6):371-81. PubMed ID: 11328663
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  • 8. Design, synthesis and brain uptake of LAT1-targeted amino acid prodrugs of dopamine.
    Peura L, Malmioja K, Huttunen K, Leppänen J, Hämäläinen M, Forsberg MM, Gynther M, Rautio J, Laine K.
    Pharm Res; 2013 Oct 01; 30(10):2523-37. PubMed ID: 24137801
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  • 9. L-type amino acid transporter 1 utilizing prodrugs of ferulic acid revealed structural features supporting the design of prodrugs for brain delivery.
    Puris E, Gynther M, Huttunen J, Auriola S, Huttunen KM.
    Eur J Pharm Sci; 2019 Mar 01; 129():99-109. PubMed ID: 30625368
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  • 11. In vitro and in vivo study of poly(ethylene glycol) conjugated ketoprofen to extend the duration of action.
    Choi HK, Chun MK, Lee SH, Jang MH, Kim HD, Jung CS, Oh SY.
    Int J Pharm; 2007 Aug 16; 341(1-2):50-7. PubMed ID: 17517483
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  • 13. The Effects of Prodrug Size and a Carbonyl Linker on l-Type Amino Acid Transporter 1-Targeted Cellular and Brain Uptake.
    Venteicher B, Merklin K, Ngo HX, Chien HC, Hutchinson K, Campbell J, Way H, Griffith J, Alvarado C, Chandra S, Hill E, Schlessinger A, Thomas AA.
    ChemMedChem; 2021 Mar 03; 16(5):869-880. PubMed ID: 33230949
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  • 15. Amino acid ester prodrugs conjugated to the α-carboxylic acid group do not display affinity for the L-type amino acid transporter 1 (LAT1).
    Rautio J, Kärkkäinen J, Huttunen KM, Gynther M.
    Eur J Pharm Sci; 2015 Jan 23; 66():36-40. PubMed ID: 25305508
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  • 17. L-Type Amino Acid Transporter 1 Enables the Efficient Brain Delivery of Small-Sized Prodrug across the Blood-Brain Barrier and into Human and Mouse Brain Parenchymal Cells.
    Montaser AB, Järvinen J, Löffler S, Huttunen J, Auriola S, Lehtonen M, Jalkanen A, Huttunen KM.
    ACS Chem Neurosci; 2020 Dec 16; 11(24):4301-4315. PubMed ID: 33228353
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