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Journal Abstract Search

184 related items for PubMed ID: 20727958

  • 21. Distribution and quantitation of the anti-trypanosomal diamidine 2,5-bis(4-amidinophenyl)furan (DB75) and its N-methoxy prodrug DB289 in murine brain tissue.
    Sturk LM, Brock JL, Bagnell CR, Hall JE, Tidwell RR.
    Acta Trop; 2004 Jul; 91(2):131-43. PubMed ID: 15234662
    [Abstract] [Full Text] [Related]

  • 22. Amino Acid Promoieties Alter Valproic Acid Pharmacokinetics and Enable Extended Brain Exposure.
    Gynther M, Peura L, Vernerová M, Leppänen J, Kärkkäinen J, Lehtonen M, Rautio J, Huttunen KM.
    Neurochem Res; 2016 Oct; 41(10):2797-2809. PubMed ID: 27412117
    [Abstract] [Full Text] [Related]

  • 23. Optimized prodrug approach: a means for achieving enhanced anti-inflammatory potential in experimentally induced colitis.
    Philip AK, Dabas S, Pathak K.
    J Drug Target; 2009 Apr; 17(3):235-41. PubMed ID: 19558362
    [Abstract] [Full Text] [Related]

  • 24. Developmental regulation of the rabbit blood-brain barrier LAT1 large neutral amino acid transporter mRNA and protein.
    Boado RJ, Li JY, Pardridge WM.
    Pediatr Res; 2004 Apr; 55(4):557-60. PubMed ID: 14764922
    [Abstract] [Full Text] [Related]

  • 25. [Pharmacokinetic study of ketoprofen in rat by blood microdialysis technique].
    He HB, Tang X, Cui FD.
    Yao Xue Xue Bao; 2006 May; 41(5):452-6. PubMed ID: 16848323
    [Abstract] [Full Text] [Related]

  • 26. Novel brain targeting prodrugs of naproxen based on dimethylamino group with various linkages.
    Zhang Q, Liang Z, Chen LY, Sun X, Gong T, Zhang ZR.
    Arzneimittelforschung; 2012 Jun; 62(6):261-6. PubMed ID: 22407924
    [Abstract] [Full Text] [Related]

  • 27. System L-amino acid transporters are differently expressed in rat astrocyte and C6 glioma cells.
    Kim DK, Kim IJ, Hwang S, Kook JH, Lee MC, Shin BA, Bae CS, Yoon JH, Ahn SG, Kim SA, Kanai Y, Endou H, Kim JK.
    Neurosci Res; 2004 Dec; 50(4):437-46. PubMed ID: 15567481
    [Abstract] [Full Text] [Related]

  • 28. Evaluation of the permeation characteristics of a model opioid peptide, H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (DADLE), and its cyclic prodrugs across the blood-brain barrier using an in situ perfused rat brain model.
    Chen W, Yang JZ, Andersen R, Nielsen LH, Borchardt RT.
    J Pharmacol Exp Ther; 2002 Nov; 303(2):849-57. PubMed ID: 12388672
    [Abstract] [Full Text] [Related]

  • 29. Secondary carbamate linker can facilitate the sustained release of dopamine from brain-targeted prodrug.
    Thiele NA, Kärkkäinen J, Sloan KB, Rautio J, Huttunen KM.
    Bioorg Med Chem Lett; 2018 Sep 15; 28(17):2856-2860. PubMed ID: 30055889
    [Abstract] [Full Text] [Related]

  • 30. Applications of a blood-brain barrier technology platform to predict CNS penetration of various chemotherapeutic agents. 2. Cationic peptide vectors for brain delivery.
    Adenot M, Merida P, Lahana R.
    Chemotherapy; 2007 Sep 15; 53(1):73-6. PubMed ID: 17202815
    [Abstract] [Full Text] [Related]

  • 31. Systemic and Brain Pharmacokinetics of Perforin Inhibitor Prodrugs.
    Gynther M, Pickering DS, Spicer JA, Denny WA, Huttunen KM.
    Mol Pharm; 2016 Jul 05; 13(7):2484-91. PubMed ID: 27266990
    [Abstract] [Full Text] [Related]

  • 32. Species differences in the intra-brain distribution of an L-type amino acid transporter 1 (LAT1) -utilizing compound between mice and rats.
    Jalkanen AJ, Ihalainen J, Lehtonen M, Forsberg MM, Rautio J, Huttunen KM, Gynther M.
    Int J Pharm; 2021 Mar 01; 596():120300. PubMed ID: 33540026
    [Abstract] [Full Text] [Related]

  • 33. Prodrug design for brain delivery of small- and medium-sized neuropeptides.
    Prokai-Tatrai K, Prokai L.
    Methods Mol Biol; 2011 Mar 01; 789():313-36. PubMed ID: 21922418
    [Abstract] [Full Text] [Related]

  • 34. Synthesis of pro-prodrugs L-lysine based for 5-aminosalicylic acid and 6-mercaptopurine colon specific release.
    Trombino S, Cassano R, Cilea A, Ferrarelli T, Muzzalupo R, Picci N.
    Int J Pharm; 2011 Nov 28; 420(2):290-6. PubMed ID: 21925255
    [Abstract] [Full Text] [Related]

  • 35. Enhancement of availability of cloricromene at brain level by a lipophilic prodrug.
    Pignatello R, Maltese A, Maugeri F, Bucolo C.
    J Pharm Pharmacol; 2006 Jul 28; 58(7):1001-5. PubMed ID: 16805962
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  • 36. Synthesis, in vitro and in vivo characterization of glycosyl derivatives of ibuprofen as novel prodrugs for brain drug delivery.
    Chen Q, Gong T, Liu J, Wang X, Fu H, Zhang Z.
    J Drug Target; 2009 May 28; 17(4):318-28. PubMed ID: 19558357
    [Abstract] [Full Text] [Related]

  • 37. In vitro stability and in vivo pharmacokinetic studies of a model opioid peptide, H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (DADLE), and its cyclic prodrugs.
    Yang JZ, Chen W, Borchardt RT.
    J Pharmacol Exp Ther; 2002 Nov 28; 303(2):840-8. PubMed ID: 12388671
    [Abstract] [Full Text] [Related]

  • 38. Manganese distribution across the blood-brain barrier III. The divalent metal transporter-1 is not the major mechanism mediating brain manganese uptake.
    Crossgrove JS, Yokel RA.
    Neurotoxicology; 2004 Mar 28; 25(3):451-60. PubMed ID: 15019308
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  • 39. Evaluation of hydroxyimine as cytochrome P450-selective prodrug structure.
    Kumpulainen H, Mähönen N, Laitinen ML, Jaurakkajärvi M, Raunio H, Juvonen RO, Vepsäläinen J, Järvinen T, Rautio J.
    J Med Chem; 2006 Feb 09; 49(3):1207-11. PubMed ID: 16451086
    [Abstract] [Full Text] [Related]

  • 40. Active transport of high-affinity choline and nicotine analogs into the central nervous system by the blood-brain barrier choline transporter.
    Allen DD, Lockman PR, Roder KE, Dwoskin LP, Crooks PA.
    J Pharmacol Exp Ther; 2003 Mar 09; 304(3):1268-74. PubMed ID: 12604705
    [Abstract] [Full Text] [Related]

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