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250 related items for PubMed ID: 20829391

  • 1. The inositol phosphatase SHIP2 negatively regulates insulin/IGF-I actions implicated in neuroprotection and memory function in mouse brain.
    Soeda Y, Tsuneki H, Muranaka H, Mori N, Hosoh S, Ichihara Y, Kagawa S, Wang X, Toyooka N, Takamura Y, Uwano T, Nishijo H, Wada T, Sasaoka T.
    Mol Endocrinol; 2010 Oct; 24(10):1965-77. PubMed ID: 20829391
    [Abstract] [Full Text] [Related]

  • 2. Impact of transgenic overexpression of SH2-containing inositol 5'-phosphatase 2 on glucose metabolism and insulin signaling in mice.
    Kagawa S, Soeda Y, Ishihara H, Oya T, Sasahara M, Yaguchi S, Oshita R, Wada T, Tsuneki H, Sasaoka T.
    Endocrinology; 2008 Feb; 149(2):642-50. PubMed ID: 18039790
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  • 3. SH2-containing inositol 5'-phosphatase 2 selectively impairs hypothalamic insulin signalling and regulation of food intake in mice.
    Ichihara Y, Wada T, Soeda Y, Ishii Y, Sasahara M, Tsuneki H, Sasaoka T.
    J Neuroendocrinol; 2013 Apr; 25(4):372-82. PubMed ID: 23286299
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  • 4. Dual role of SRC homology domain 2-containing inositol phosphatase 2 in the regulation of platelet-derived growth factor and insulin-like growth factor I signaling in rat vascular smooth muscle cells.
    Sasaoka T, Kikuchi K, Wada T, Sato A, Hori H, Murakami S, Fukui K, Ishihara H, Aota R, Kimura I, Kobayashi M.
    Endocrinology; 2003 Sep; 144(9):4204-14. PubMed ID: 12933696
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  • 5. Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase, SHIP2.
    Suwa A, Yamamoto T, Sawada A, Minoura K, Hosogai N, Tahara A, Kurama T, Shimokawa T, Aramori I.
    Br J Pharmacol; 2009 Oct; 158(3):879-87. PubMed ID: 19694723
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  • 8. Lipid phosphatases as a possible therapeutic target in cases of type 2 diabetes and obesity.
    Sasaoka T, Wada T, Tsuneki H.
    Pharmacol Ther; 2006 Dec; 112(3):799-809. PubMed ID: 16842857
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  • 9. Membrane localization of Src homology 2-containing inositol 5'-phosphatase 2 via Shc association is required for the negative regulation of insulin signaling in Rat1 fibroblasts overexpressing insulin receptors.
    Ishihara H, Sasaoka T, Ishiki M, Wada T, Hori H, Kagawa S, Kobayashi M.
    Mol Endocrinol; 2002 Oct; 16(10):2371-81. PubMed ID: 12351701
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  • 10. The association between the SH2-containing inositol polyphosphate 5-Phosphatase 2 (SHIP2) and the adaptor protein APS has an impact on biochemical properties of both partners.
    Onnockx S, De Schutter J, Blockmans M, Xie J, Jacobs C, Vanderwinden JM, Erneux C, Pirson I.
    J Cell Physiol; 2008 Jan; 214(1):260-72. PubMed ID: 17620296
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  • 12. Ebselen enhances insulin sensitivity and decreases oxidative stress by inhibiting SHIP2 and protects from inflammation in diabetic mice.
    Polianskyte-Prause Z, Tolvanen TA, Lindfors S, Kon K, Hautala LC, Wang H, Wada T, Tsuneki H, Sasaoka T, Lehtonen S.
    Int J Biol Sci; 2022 Jan; 18(5):1852-1864. PubMed ID: 35342343
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  • 13. Lipid phosphatase SHIP2 downregulates insulin signalling in podocytes.
    Hyvönen ME, Saurus P, Wasik A, Heikkilä E, Havana M, Trokovic R, Saleem M, Holthöfer H, Lehtonen S.
    Mol Cell Endocrinol; 2010 Oct 26; 328(1-2):70-9. PubMed ID: 20654688
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  • 14. SH2-containing inositol phosphatase 2 predominantly regulates Akt2, and not Akt1, phosphorylation at the plasma membrane in response to insulin in 3T3-L1 adipocytes.
    Sasaoka T, Wada T, Fukui K, Murakami S, Ishihara H, Suzuki R, Tobe K, Kadowaki T, Kobayashi M.
    J Biol Chem; 2004 Apr 09; 279(15):14835-43. PubMed ID: 14744864
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  • 15. SH2 domain-containing inositol 5-phosphatase (SHIP2) inhibition ameliorates high glucose-induced de-novo lipogenesis and VLDL production through regulating AMPK/mTOR/SREBP1 pathway and ROS production in HepG2 cells.
    Gorgani-Firuzjaee S, Meshkani R.
    Free Radic Biol Med; 2015 Dec 09; 89():679-89. PubMed ID: 26456051
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  • 16. Overexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5'-phosphatase catalytic activity.
    Wada T, Sasaoka T, Funaki M, Hori H, Murakami S, Ishiki M, Haruta T, Asano T, Ogawa W, Ishihara H, Kobayashi M.
    Mol Cell Biol; 2001 Mar 09; 21(5):1633-46. PubMed ID: 11238900
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  • 18. SHIP2: an emerging target for the treatment of type 2 diabetes mellitus.
    Baumgartener JW.
    Curr Drug Targets Immune Endocr Metabol Disord; 2003 Dec 09; 3(4):291-8. PubMed ID: 14683460
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  • 19. Impact of Src homology 2-containing inositol 5'-phosphatase 2 on the regulation of insulin signaling leading to protein synthesis in 3T3-L1 adipocytes cultured with excess amino acids.
    Murakami S, Sasaoka T, Wada T, Fukui K, Nagira K, Ishihara H, Usui I, Kobayashi M.
    Endocrinology; 2004 Jul 09; 145(7):3215-23. PubMed ID: 15044364
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  • 20. SHIP2: a "new" insulin pathway target for aging research.
    Accardi G, Virruso C, Balistreri CR, Emanuele F, Licastro F, Monastero R, Porcellini E, Vasto S, Verga S, Caruso C, Candore G.
    Rejuvenation Res; 2014 Apr 09; 17(2):221-5. PubMed ID: 24313349
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