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Journal Abstract Search

187 related items for PubMed ID: 20836985

  • 21. Structures of cytochrome P450 2B6 bound to 4-benzylpyridine and 4-(4-nitrobenzyl)pyridine: insight into inhibitor binding and rearrangement of active site side chains.
    Shah MB, Pascual J, Zhang Q, Stout CD, Halpert JR.
    Mol Pharmacol; 2011 Dec; 80(6):1047-55. PubMed ID: 21875942
    [Abstract] [Full Text] [Related]

  • 22. Quantitative structure-activity relationships (QSARs) for inhibitors and substrates of CYP2B enzymes: importance of compound lipophilicity in explanation of potency differences.
    Lewis DF, Ito Y, Lake BG.
    J Enzyme Inhib Med Chem; 2010 Oct; 25(5):679-84. PubMed ID: 20100069
    [Abstract] [Full Text] [Related]

  • 23. Mechanism-based inactivation of cytochromes P450 2E1 and 2E1 T303A by tert-butyl acetylenes: characterization of reactive intermediate adducts to the heme and apoprotein.
    Blobaum AL, Kent UM, Alworth WL, Hollenberg PF.
    Chem Res Toxicol; 2002 Dec; 15(12):1561-71. PubMed ID: 12482238
    [Abstract] [Full Text] [Related]

  • 24. Peroxynitrite inactivation of human cytochrome P450s 2B6 and 2E1: heme modification and site-specific nitrotyrosine formation.
    Lin HL, Myshkin E, Waskell L, Hollenberg PF.
    Chem Res Toxicol; 2007 Nov; 20(11):1612-22. PubMed ID: 17907788
    [Abstract] [Full Text] [Related]

  • 25. Elucidation of amino acid residues critical for unique activities of rabbit cytochrome P450 2B5 using hybrid enzymes and reciprocal site-directed mutagenesis with rabbit cytochrome P450 2B4.
    Szklarz GD, He YQ, Kedzie KM, Halpert JR, Burnett VL.
    Arch Biochem Biophys; 1996 Mar 15; 327(2):308-18. PubMed ID: 8619620
    [Abstract] [Full Text] [Related]

  • 26. Coumarin Derivatives as Substrate Probes of Mammalian Cytochromes P450 2B4 and 2B6: Assessing the Importance of 7-Alkoxy Chain Length, Halogen Substitution, and Non-Active Site Mutations.
    Liu J, Shah MB, Zhang Q, Stout CD, Halpert JR, Wilderman PR.
    Biochemistry; 2016 Apr 05; 55(13):1997-2007. PubMed ID: 26982502
    [Abstract] [Full Text] [Related]

  • 27. Identification of 17-alpha-ethynylestradiol-modified active site peptides and glutathione conjugates formed during metabolism and inactivation of P450s 2B1 and 2B6.
    Kent UM, Lin HL, Mills DE, Regal KA, Hollenberg PF.
    Chem Res Toxicol; 2006 Feb 05; 19(2):279-87. PubMed ID: 16485904
    [Abstract] [Full Text] [Related]

  • 28. Thiophene derivatives as new mechanism-based inhibitors of cytochromes P-450: inactivation of yeast-expressed human liver cytochrome P-450 2C9 by tienilic acid.
    López-Garcia MP, Dansette PM, Mansuy D.
    Biochemistry; 1994 Jan 11; 33(1):166-75. PubMed ID: 8286335
    [Abstract] [Full Text] [Related]

  • 29. Rational engineering of cytochromes P450 2B6 and 2B11 for enhanced stability: Insights into structural importance of residue 334.
    Talakad JC, Wilderman PR, Davydov DR, Kumar S, Halpert JR.
    Arch Biochem Biophys; 2010 Feb 15; 494(2):151-8. PubMed ID: 19944064
    [Abstract] [Full Text] [Related]

  • 30. Formation of a novel reversible cytochrome P450 spectral intermediate: role of threonine 303 in P450 2E1 inactivation.
    Blobaum AL, Lu Y, Kent UM, Wang S, Hollenberg PF.
    Biochemistry; 2004 Sep 28; 43(38):11942-52. PubMed ID: 15379534
    [Abstract] [Full Text] [Related]

  • 31. Mechanism-based inactivators as probes of cytochrome P450 structure and function.
    Kent UM, Juschyshyn MI, Hollenberg PF.
    Curr Drug Metab; 2001 Sep 28; 2(3):215-43. PubMed ID: 11513328
    [Abstract] [Full Text] [Related]

  • 32. Kinetics of oxidation of benzphetamine by compounds I of cytochrome P450 2B4 and its mutants.
    Sheng X, Zhang H, Im SC, Horner JH, Waskell L, Hollenberg PF, Newcomb M.
    J Am Chem Soc; 2009 Mar 04; 131(8):2971-6. PubMed ID: 19209859
    [Abstract] [Full Text] [Related]

  • 33. Catalytic selectivity and mechanism-based inactivation of stably expressed and hepatic cytochromes P450 2B4 and 2B5: implications of the cytochrome P450 2B5 polymorphism.
    Grimm SW, Dyroff MC, Philpot RM, Halpert JR.
    Mol Pharmacol; 1994 Dec 04; 46(6):1090-9. PubMed ID: 7808429
    [Abstract] [Full Text] [Related]

  • 34. Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution.
    Gay SC, Shah MB, Talakad JC, Maekawa K, Roberts AG, Wilderman PR, Sun L, Yang JY, Huelga SC, Hong WX, Zhang Q, Stout CD, Halpert JR.
    Mol Pharmacol; 2010 Apr 04; 77(4):529-38. PubMed ID: 20061448
    [Abstract] [Full Text] [Related]

  • 35. Mechanism-based inactivation of CYP2B1 and its F-helix mutant by two tert-butyl acetylenic compounds: covalent modification of prosthetic heme versus apoprotein.
    Lin HL, Zhang H, Noon KR, Hollenberg PF.
    J Pharmacol Exp Ther; 2009 Nov 04; 331(2):392-403. PubMed ID: 19700628
    [Abstract] [Full Text] [Related]

  • 36. Progress in cytochrome P450 active site modeling.
    Kemp CA, Maréchal JD, Sutcliffe MJ.
    Arch Biochem Biophys; 2005 Jan 15; 433(2):361-8. PubMed ID: 15581592
    [Abstract] [Full Text] [Related]

  • 37. Mechanism-based inactivation of human cytochrome P450 2B6 by clopidogrel: involvement of both covalent modification of cysteinyl residue 475 and loss of heme.
    Zhang H, Amunugama H, Ney S, Cooper N, Hollenberg PF.
    Mol Pharmacol; 2011 Nov 15; 80(5):839-47. PubMed ID: 21862689
    [Abstract] [Full Text] [Related]

  • 38. Investigation of the mechanisms underlying the differential effects of the K262R mutation of P450 2B6 on catalytic activity.
    Bumpus NN, Hollenberg PF.
    Mol Pharmacol; 2008 Oct 15; 74(4):990-9. PubMed ID: 18621926
    [Abstract] [Full Text] [Related]

  • 39. Differential behavior of the sub-sites of cytochrome 450 active site in binding of substrates, and products (implications for coupling/uncoupling).
    Narasimhulu S.
    Biochim Biophys Acta; 2007 Mar 15; 1770(3):360-75. PubMed ID: 17134838
    [Abstract] [Full Text] [Related]

  • 40. The mechanism-based inactivation of human cytochrome P450 2B6 by phencyclidine.
    Jushchyshyn MI, Kent UM, Hollenberg PF.
    Drug Metab Dispos; 2003 Jan 15; 31(1):46-52. PubMed ID: 12485952
    [Abstract] [Full Text] [Related]

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