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Journal Abstract Search

105 related items for PubMed ID: 20857914

  • 1. Design and synthesis of prolylcarboxypeptidase (PrCP) inhibitors to validate PrCP as a potential target for obesity.
    Zhou C, Garcia-Calvo M, Pinto S, Lombardo M, Feng Z, Bender K, Pryor KD, Bhatt UR, Chabin RM, Geissler WM, Shen Z, Tong X, Zhang Z, Wong KK, Roy RS, Chapman KT, Yang L, Xiong Y.
    J Med Chem; 2010 Oct 14; 53(19):7251-63. PubMed ID: 20857914
    [Abstract] [Full Text] [Related]

  • 2. Discovery and optimization of orally active cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors.
    Debenham JS, Graham TH, Verras A, Zhang Y, Clements MJ, Kuethe JT, Madsen-Duggan C, Liu W, Bhatt UR, Chen D, Chen Q, Garcia-Calvo M, Geissler WM, He H, Li X, Lisnock J, Shen Z, Tong X, Tung EC, Wiltsie J, Xu S, Hale JJ, Pinto S, Shen DM.
    Bioorg Med Chem Lett; 2013 Dec 01; 23(23):6228-33. PubMed ID: 24157366
    [Abstract] [Full Text] [Related]

  • 3. Discovery of benzimidazole pyrrolidinyl amides as prolylcarboxypeptidase inhibitors.
    Shen HC, Ding FX, Zhou C, Xiong Y, Verras A, Chabin RM, Xu S, Tong X, Xie D, Lassman ME, Bhatt UR, Garcia-Calvo MM, Geissler W, Shen Z, Chen D, Sinharoy R, Hale JJ, Tata JR, Pinto S, Shen DM, Colletti SL.
    Bioorg Med Chem Lett; 2011 Mar 01; 21(5):1299-305. PubMed ID: 21315588
    [Abstract] [Full Text] [Related]

  • 4. Halothiophene benzimidazoles as P1 surrogates of inhibitors of blood coagulation factor Xa.
    Mederski WW, Dorsch D, Anzali S, Gleitz J, Cezanne B, Tsaklakidis C.
    Bioorg Med Chem Lett; 2004 Jul 16; 14(14):3763-9. PubMed ID: 15203158
    [Abstract] [Full Text] [Related]

  • 5. The discovery of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors.
    Graham TH, Shen HC, Liu W, Xiong Y, Verras A, Bleasby K, Bhatt UR, Chabin RM, Chen D, Chen Q, Garcia-Calvo M, Geissler WM, He H, Lassman ME, Shen Z, Tong X, Tung EC, Xie D, Xu S, Colletti SL, Tata JR, Hale JJ, Pinto S, Shen DM.
    Bioorg Med Chem Lett; 2012 Jan 01; 22(1):658-65. PubMed ID: 22079761
    [Abstract] [Full Text] [Related]

  • 6. Discovery of benzodihydroisofurans as novel, potent, bioavailable and brain-penetrant prolylcarboxypeptidase inhibitors.
    Shen HC, Ding FX, Jiang J, Verras A, Chabin RM, Xu S, Tong X, Chen Q, Xie D, Lassman ME, Bhatt UR, Garcia-Calvo MM, Geissler W, Shen Z, Murphy BA, Gorski JN, Wiltsie J, SinhaRoy R, Hale JJ, Pinto S, Shen DM.
    Bioorg Med Chem Lett; 2012 Feb 15; 22(4):1550-6. PubMed ID: 22264488
    [Abstract] [Full Text] [Related]

  • 7. Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists.
    Wu WL, Burnett DA, Caplen MA, Domalski MS, Bennett C, Greenlee WJ, Hawes BE, O'Neill K, Weig B, Weston D, Spar B, Kowalski T.
    Bioorg Med Chem Lett; 2006 Jul 15; 16(14):3674-8. PubMed ID: 16690315
    [Abstract] [Full Text] [Related]

  • 8. A new class of prolylcarboxypeptidase inhibitors, part 2: the aminocyclopentanes.
    Graham TH, Liu W, Verras A, Reibarkh M, Bleasby K, Bhatt UR, Chen Q, Garcia-Calvo M, Geissler WM, Gorski JN, He H, Lassman ME, Lisnock J, Li X, Shen Z, Tong X, Tung EC, Wiltsie J, Xie D, Xu S, Xiao J, Hale JJ, Pinto S, Shen DM.
    Bioorg Med Chem Lett; 2012 Apr 15; 22(8):2818-22. PubMed ID: 22444685
    [Abstract] [Full Text] [Related]

  • 9. Novel potent hepatitis C virus NS3 serine protease inhibitors derived from proline-based macrocycles.
    Chen KX, Njoroge FG, Arasappan A, Venkatraman S, Vibulbhan B, Yang W, Parekh TN, Pichardo J, Prongay A, Cheng KC, Butkiewicz N, Yao N, Madison V, Girijavallabhan V.
    J Med Chem; 2006 Feb 09; 49(3):995-1005. PubMed ID: 16451065
    [Abstract] [Full Text] [Related]

  • 10. Prolylcarboxypeptidase (PrCP) inhibitors and the therapeutic uses thereof: a patent review.
    Graham TH.
    Expert Opin Ther Pat; 2017 Oct 09; 27(10):1077-1088. PubMed ID: 28699813
    [Abstract] [Full Text] [Related]

  • 11. Discovery of a new class of potent prolylcarboxypeptidase inhibitors derived from alanine.
    Wu Z, Yang C, Xiong Y, Feng Z, Lombardo M, Verras A, Chabin RM, Xu S, Tong X, Xie D, Lassman ME, Bhatt UR, Garcia-Calvo MM, Geissler W, Shen Z, Chen Q, Sinharoy R, Hale JJ, Tata JR, Pinto S, Shen DM, Colletti SL.
    Bioorg Med Chem Lett; 2012 Feb 15; 22(4):1774-8. PubMed ID: 22248857
    [Abstract] [Full Text] [Related]

  • 12. A new class of prolylcarboxypeptidase inhibitors, part 1: discovery and evaluation.
    Graham TH, Liu W, Verras A, Sebhat IK, Xiong Y, Bleasby K, Bhatt UR, Chen Q, Garcia-Calvo M, Geissler WM, Gorski JN, He H, Lassman ME, Lisnock J, Li X, Shen Z, Tong X, Tung EC, Wiltsie J, Xiao J, Xie D, Xu S, Hale JJ, Pinto S, Shen DM.
    Bioorg Med Chem Lett; 2012 Apr 15; 22(8):2811-7. PubMed ID: 22444683
    [Abstract] [Full Text] [Related]

  • 13. Synthesis and in vitro evaluation of new azaphenylalanine derivatives as serine protease inhibitors.
    Obreza A, Stegnar M, Trampus-Bakija A, Prezelj A, Urleb U.
    Pharmazie; 2004 Oct 15; 59(10):739-43. PubMed ID: 15544050
    [Abstract] [Full Text] [Related]

  • 14. Discovery of novel, orally available benzimidazoles as melanin concentrating hormone receptor 1 (MCHR1) antagonists.
    Sasmal PK, Sasmal S, Rao PT, Venkatesham B, Roshaiah M, Abbineni C, Khanna I, Jadhav VP, Suresh J, Talwar R, Muzeeb S, Receveur JM, Frimurer TM, Rist Ø, Elster L, Högberg T.
    Bioorg Med Chem Lett; 2010 Sep 15; 20(18):5443-8. PubMed ID: 20724156
    [Abstract] [Full Text] [Related]

  • 15. Discovery of aminoheterocycles as potent and brain penetrant prolylcarboxypeptidase inhibitors.
    Wu Z, Yang C, Graham TH, Verras A, Chabin RM, Xu S, Tong X, Xie D, Lassman ME, Bhatt UR, Garcia-Calvo MM, Shen Z, Chen Q, Bleasby K, Sinharoy R, Hale JJ, Tata JR, Pinto S, Colletti SL, Shen DM.
    Bioorg Med Chem Lett; 2012 Feb 15; 22(4):1727-30. PubMed ID: 22290078
    [Abstract] [Full Text] [Related]

  • 16. Secondary amides of sulfonylated 3-amidinophenylalanine. New potent and selective inhibitors of matriptase.
    Steinmetzer T, Schweinitz A, Stürzebecher A, Dönnecke D, Uhland K, Schuster O, Steinmetzer P, Müller F, Friedrich R, Than ME, Bode W, Stürzebecher J.
    J Med Chem; 2006 Jul 13; 49(14):4116-26. PubMed ID: 16821772
    [Abstract] [Full Text] [Related]

  • 17. Design and synthesis of orally bioavailable benzimidazoles as Raf kinase inhibitors.
    Ramurthy S, Subramanian S, Aikawa M, Amiri P, Costales A, Dove J, Fong S, Jansen JM, Levine B, Ma S, McBride CM, Michaelian J, Pick T, Poon DJ, Girish S, Shafer CM, Stuart D, Sung L, Renhowe PA.
    J Med Chem; 2008 Nov 27; 51(22):7049-52. PubMed ID: 18942827
    [Abstract] [Full Text] [Related]

  • 18. Influence of a novel inhibitor (UM8190) of prolylcarboxypeptidase (PRCP) on appetite and thrombosis.
    Rabey FM, Gadepalli RS, Diano S, Cheng Q, Tabrizian T, Gailani D, Rimoldi JM, Shariat-Madar Z.
    Curr Med Chem; 2012 Nov 27; 19(24):4194-206. PubMed ID: 22664251
    [Abstract] [Full Text] [Related]

  • 19. Application of a flexible synthesis of (5R)-thiolactomycin to develop new inhibitors of type I fatty acid synthase.
    McFadden JM, Medghalchi SM, Thupari JN, Pinn ML, Vadlamudi A, Miller KI, Kuhajda FP, Townsend CA.
    J Med Chem; 2005 Feb 24; 48(4):946-61. PubMed ID: 15715465
    [Abstract] [Full Text] [Related]

  • 20. Design of potent selective zinc-mediated serine protease inhibitors.
    Katz BA, Clark JM, Finer-Moore JS, Jenkins TE, Johnson CR, Ross MJ, Luong C, Moore WR, Stroud RM.
    Nature; 1998 Feb 05; 391(6667):608-12. PubMed ID: 9468142
    [Abstract] [Full Text] [Related]

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