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Journal Abstract Search

290 related items for PubMed ID: 20863006

  • 1. Synthesis of 1,5-diarylpyrazol-3-propanoic acids towards inhibition of cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4 formation.
    Ergün BC, Nuñez MT, Labeaga L, Ledo F, Darlington J, Bain G, Cakir B, Banoglu E.
    Arzneimittelforschung; 2010; 60(8):497-505. PubMed ID: 20863006
    [Abstract] [Full Text] [Related]

  • 2. Synthesis and biological evaluation of a new class of acyl derivatives of 3-amino-1-phenyl-4,5-dihydro-1H-pyrazol-5-one as potential dual cyclooxygenase (COX-1 and COX-2) and human lipoxygenase (5-LOX) inhibitors.
    Cusan C, Spalluto G, Prato M, Adams M, Bodensieck A, Bauer R, Tubaro A, Bernardi P, Da Ros T.
    Farmaco; 2005 Apr; 60(4):327-32. PubMed ID: 15848208
    [Abstract] [Full Text] [Related]

  • 3. Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4-formation.
    Schühly W, Hüfner A, Pferschy-Wenzig EM, Prettner E, Adams M, Bodensieck A, Kunert O, Oluwemimo A, Haslinger E, Bauer R.
    Bioorg Med Chem; 2009 Jul 01; 17(13):4459-65. PubMed ID: 19481465
    [Abstract] [Full Text] [Related]

  • 4. Synthesis and structure-activity relationship studies of 1,3-diarylprop-2-yn-1-ones: dual inhibitors of cyclooxygenases and lipoxygenases.
    Rao PN, Chen QH, Knaus EE.
    J Med Chem; 2006 Mar 09; 49(5):1668-83. PubMed ID: 16509583
    [Abstract] [Full Text] [Related]

  • 5. Phenylsulphonyl urenyl chalcone derivatives as dual inhibitors of cyclo-oxygenase-2 and 5-lipoxygenase.
    Araico A, Terencio MC, Alcaraz MJ, Domínguez JN, León C, Ferrándiz ML.
    Life Sci; 2006 May 15; 78(25):2911-8. PubMed ID: 16360707
    [Abstract] [Full Text] [Related]

  • 6. Derivatives of schisandrin with increased inhibitory potential on prostaglandin E(2) and leukotriene B(4) formation in vitro.
    Blunder M, Pferschy-Wenzig EM, Fabian WM, Hüfner A, Kunert O, Saf R, Schühly W, Bauer R.
    Bioorg Med Chem; 2010 Apr 01; 18(7):2809-15. PubMed ID: 20236826
    [Abstract] [Full Text] [Related]

  • 7. Design, synthesis, and biological evaluation of (E)-3-(4-methanesulfonylphenyl)-2-(aryl)acrylic acids as dual inhibitors of cyclooxygenases and lipoxygenases.
    Moreau A, Chen QH, Praveen Rao PN, Knaus EE.
    Bioorg Med Chem; 2006 Dec 01; 14(23):7716-27. PubMed ID: 16931030
    [Abstract] [Full Text] [Related]

  • 8. Dual inhibition of 5-lipoxygenase/cyclooxygenase by a reconstituted homeopathic remedy; possible explanation for clinical efficacy and favourable gastrointestinal tolerability.
    Jäggi R, Würgler U, Grandjean F, Weiser M.
    Inflamm Res; 2004 Apr 01; 53(4):150-7. PubMed ID: 15060721
    [Abstract] [Full Text] [Related]

  • 9. Synthesis of celecoxib analogues possessing a N-difluoromethyl-1,2-dihydropyrid-2-one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.
    Chowdhury MA, Abdellatif KR, Dong Y, Das D, Suresh MR, Knaus EE.
    J Med Chem; 2009 Mar 26; 52(6):1525-9. PubMed ID: 19296694
    [Abstract] [Full Text] [Related]

  • 10. Synthesis of the butanamide derivative S 19812, a new dual inhibitor of cyclooxygenase and lipoxygenase pathways.
    Tordjman C, Sauveur F, Droual M, Briss S, Andre N, Bellot I, Deschamps C, Wierzbicki M.
    Arzneimittelforschung; 2003 Mar 26; 53(11):774-9. PubMed ID: 14677373
    [Abstract] [Full Text] [Related]

  • 11. Synthesis and biological evaluation of 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives as novel COX-1/2 and 5-LOX inhibitors.
    Lai Y, Ma L, Huang W, Yu X, Zhang Y, Ji H, Tian J.
    Bioorg Med Chem Lett; 2010 Dec 15; 20(24):7349-53. PubMed ID: 21055929
    [Abstract] [Full Text] [Related]

  • 12. Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors.
    Reddy MV, Billa VK, Pallela VR, Mallireddigari MR, Boominathan R, Gabriel JL, Reddy EP.
    Bioorg Med Chem; 2008 Apr 01; 16(7):3907-16. PubMed ID: 18272371
    [Abstract] [Full Text] [Related]

  • 13. 3-(2-Methoxytetrahydrofuran-2-yl)pyrazoles: a novel class of potent, selective cyclooxygenase-2 (COX-2) inhibitors.
    Ranatunge RR, Earl RA, Garvey DS, Janero DR, Letts LG, Martino AM, Murty MG, Richardson SK, Schwalb DJ, Young DV, Zemtseva IS.
    Bioorg Med Chem Lett; 2004 Dec 20; 14(24):6049-52. PubMed ID: 15546727
    [Abstract] [Full Text] [Related]

  • 14. Tepoxalin: a dual cyclooxygenase/5-lipoxygenase inhibitor of arachidonic acid metabolism with potent anti-inflammatory activity and a favorable gastrointestinal profile.
    Argentieri DC, Ritchie DM, Ferro MP, Kirchner T, Wachter MP, Anderson DW, Rosenthale ME, Capetola RJ.
    J Pharmacol Exp Ther; 1994 Dec 20; 271(3):1399-408. PubMed ID: 7996452
    [Abstract] [Full Text] [Related]

  • 15. Synthesis of celecoxib analogs that possess a N-hydroxypyrid-2(1H)one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.
    Chowdhury MA, Abdellatif KR, Dong Y, Das D, Suresh MR, Knaus EE.
    Bioorg Med Chem Lett; 2008 Dec 01; 18(23):6138-41. PubMed ID: 18945614
    [Abstract] [Full Text] [Related]

  • 16. Synthesis and biological evaluation of a novel class of rofecoxib analogues as dual inhibitors of cyclooxygenases (COXs) and lipoxygenases (LOXs).
    Chen QH, Rao PN, Knaus EE.
    Bioorg Med Chem; 2006 Dec 01; 14(23):7898-909. PubMed ID: 16904331
    [Abstract] [Full Text] [Related]

  • 17. Synthesis and biological evaluation of new phenidone analogues as potential dual cyclooxygenase (COX-1 and COX-2) and human lipoxygenase (5-LOX) inhibitors.
    Cusan C, Spalluto G, Prato M, Adams M, Bodensieck A, Bauer R, Tubaro A, Bernardi P, Da Ros T.
    Farmaco; 2005 Jan 01; 60(1):7-13. PubMed ID: 15652362
    [Abstract] [Full Text] [Related]

  • 18. Synthesis and screening of cyclooxygenase inhibitory activity of some 1,3-dioxoisoindoline derivatives.
    Cizmeciolu M, Pabuguoglu V, Ballar P, Pabuççuoğlu A, Soyer Z.
    Arzneimittelforschung; 2011 Jan 01; 61(3):186-90. PubMed ID: 21528644
    [Abstract] [Full Text] [Related]

  • 19. 5-Lipoxygenase inhibitors: synthesis and structure-activity relationships of a series of 1-aryl-2H,4H-tetrahydro-1,2,4-triazin-3-ones.
    Bhatia PA, Brooks CD, Basha A, Ratajczyk JD, Gunn BP, Bouska JB, Lanni C, Young PR, Bell RL, Carter GW.
    J Med Chem; 1996 Sep 27; 39(20):3938-50. PubMed ID: 8831760
    [Abstract] [Full Text] [Related]

  • 20. Synthesis and biological activity of disubstituted 4,5-polymethylenepyrazoles as selective cyclooxygenase-2 inhibitors.
    Yu JW, Kim HH, Jahng Y.
    Pharmazie; 2002 May 27; 57(5):301-5. PubMed ID: 12061251
    [Abstract] [Full Text] [Related]

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