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Journal Abstract Search

149 related items for PubMed ID: 20869417

  • 1. Functional coupling of Cys-226 and Cys-296 in the glucagon-like peptide-1 (GLP-1) receptor indicates a disulfide bond that is close to the activation pocket.
    Mann RJ, Al-Sabah S, de Maturana RL, Sinfield JK, Donnelly D.
    Peptides; 2010 Dec; 31(12):2289-93. PubMed ID: 20869417
    [Abstract] [Full Text] [Related]

  • 2. Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activation.
    Koole C, Wootten D, Simms J, Miller LJ, Christopoulos A, Sexton PM.
    J Biol Chem; 2012 Feb 03; 287(6):3642-58. PubMed ID: 22147710
    [Abstract] [Full Text] [Related]

  • 3. Residues within the transmembrane domain of the glucagon-like peptide-1 receptor involved in ligand binding and receptor activation: modelling the ligand-bound receptor.
    Coopman K, Wallis R, Robb G, Brown AJ, Wilkinson GF, Timms D, Willars GB.
    Mol Endocrinol; 2011 Oct 03; 25(10):1804-18. PubMed ID: 21868452
    [Abstract] [Full Text] [Related]

  • 4. Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) differentially regulates orthosteric but not allosteric agonist binding and function.
    Koole C, Wootten D, Simms J, Savage EE, Miller LJ, Christopoulos A, Sexton PM.
    J Biol Chem; 2012 Feb 03; 287(6):3659-73. PubMed ID: 22147709
    [Abstract] [Full Text] [Related]

  • 5. Development of a cysteine-deprived and C-terminally truncated GLP-1 receptor.
    Underwood CR, Knudsen LB, Garibay PW, Peters GH, Reedtz-Runge S.
    Peptides; 2013 Nov 03; 49():100-8. PubMed ID: 24045233
    [Abstract] [Full Text] [Related]

  • 6. Ligand binding pocket formed by evolutionarily conserved residues in the glucagon-like peptide-1 (GLP-1) receptor core domain.
    Moon MJ, Lee YN, Park S, Reyes-Alcaraz A, Hwang JI, Millar RP, Choe H, Seong JY.
    J Biol Chem; 2015 Feb 27; 290(9):5696-706. PubMed ID: 25561730
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  • 7. Crystal structure of glucagon-like peptide-1 in complex with the extracellular domain of the glucagon-like peptide-1 receptor.
    Underwood CR, Garibay P, Knudsen LB, Hastrup S, Peters GH, Rudolph R, Reedtz-Runge S.
    J Biol Chem; 2010 Jan 01; 285(1):723-30. PubMed ID: 19861722
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  • 10. Systematic analysis of the entire second extracellular loop of the V(1a) vasopressin receptor: key residues, conserved throughout a G-protein-coupled receptor family, identified.
    Conner M, Hawtin SR, Simms J, Wootten D, Lawson Z, Conner AC, Parslow RA, Wheatley M.
    J Biol Chem; 2007 Jun 15; 282(24):17405-12. PubMed ID: 17403667
    [Abstract] [Full Text] [Related]

  • 11. Understanding the molecular functions of the second extracellular loop (ECL2) of the calcitonin gene-related peptide (CGRP) receptor using a comprehensive mutagenesis approach.
    Woolley MJ, Simms J, Mobarec JC, Reynolds CA, Poyner DR, Conner AC.
    Mol Cell Endocrinol; 2017 Oct 15; 454():39-49. PubMed ID: 28572046
    [Abstract] [Full Text] [Related]

  • 12. Differential Requirement of the Extracellular Domain in Activation of Class B G Protein-coupled Receptors.
    Zhao LH, Yin Y, Yang D, Liu B, Hou L, Wang X, Pal K, Jiang Y, Feng Y, Cai X, Dai A, Liu M, Wang MW, Melcher K, Xu HE.
    J Biol Chem; 2016 Jul 15; 291(29):15119-30. PubMed ID: 27226600
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  • 13. The glucagon-like peptide-2 receptor C terminus modulates beta-arrestin-2 association but is dispensable for ligand-induced desensitization, endocytosis, and G-protein-dependent effector activation.
    Estall JL, Koehler JA, Yusta B, Drucker DJ.
    J Biol Chem; 2005 Jun 10; 280(23):22124-34. PubMed ID: 15817468
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  • 15. A second disulfide bridge from the N-terminal domain to extracellular loop 2 dampens receptor activity in GPR39.
    Storjohann L, Holst B, Schwartz TW.
    Biochemistry; 2008 Sep 02; 47(35):9198-207. PubMed ID: 18693759
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  • 16. An intramolecular disulfide bond between conserved extracellular cysteines in the gonadotropin-releasing hormone receptor is essential for binding and activation.
    Cook JV, Eidne KA.
    Endocrinology; 1997 Jul 02; 138(7):2800-6. PubMed ID: 9202220
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  • 17. Structural Determinants of Binding the Seven-transmembrane Domain of the Glucagon-like Peptide-1 Receptor (GLP-1R).
    Yang D, de Graaf C, Yang L, Song G, Dai A, Cai X, Feng Y, Reedtz-Runge S, Hanson MA, Yang H, Jiang H, Stevens RC, Wang MW.
    J Biol Chem; 2016 Jun 17; 291(25):12991-3004. PubMed ID: 27059958
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  • 19. Extracellular Loop 2 of the Adenosine A1 Receptor Has a Key Role in Orthosteric Ligand Affinity and Agonist Efficacy.
    Nguyen AT, Baltos JA, Thomas T, Nguyen TD, Muñoz LL, Gregory KJ, White PJ, Sexton PM, Christopoulos A, May LT.
    Mol Pharmacol; 2016 Dec 17; 90(6):703-714. PubMed ID: 27683014
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  • 20. The amino terminal domain of the glucagon-like peptide-1 receptor is a critical determinant of subtype specificity.
    Graziano MP, Hey PJ, Strader CD.
    Recept Channels; 1996 Dec 17; 4(1):9-17. PubMed ID: 8723643
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