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Journal Abstract Search

330 related items for PubMed ID: 20869591

  • 1. SCA1-like disease in mice expressing wild-type ataxin-1 with a serine to aspartic acid replacement at residue 776.
    Duvick L, Barnes J, Ebner B, Agrawal S, Andresen M, Lim J, Giesler GJ, Zoghbi HY, Orr HT.
    Neuron; 2010 Sep 23; 67(6):929-35. PubMed ID: 20869591
    [Abstract] [Full Text] [Related]

  • 2. Purkinje cell ataxin-1 modulates climbing fiber synaptic input in developing and adult mouse cerebellum.
    Ebner BA, Ingram MA, Barnes JA, Duvick LA, Frisch JL, Clark HB, Zoghbi HY, Ebner TJ, Orr HT.
    J Neurosci; 2013 Mar 27; 33(13):5806-20. PubMed ID: 23536093
    [Abstract] [Full Text] [Related]

  • 3. Serine 776 of ataxin-1 is critical for polyglutamine-induced disease in SCA1 transgenic mice.
    Emamian ES, Kaytor MD, Duvick LA, Zu T, Tousey SK, Zoghbi HY, Clark HB, Orr HT.
    Neuron; 2003 May 08; 38(3):375-87. PubMed ID: 12741986
    [Abstract] [Full Text] [Related]

  • 4. Abnormalities in the climbing fiber-Purkinje cell circuitry contribute to neuronal dysfunction in ATXN1[82Q] mice.
    Barnes JA, Ebner BA, Duvick LA, Gao W, Chen G, Orr HT, Ebner TJ.
    J Neurosci; 2011 Sep 07; 31(36):12778-89. PubMed ID: 21900557
    [Abstract] [Full Text] [Related]

  • 5. Focused cerebellar laser light induced hyperthermia improves symptoms and pathology of polyglutamine disease SCA1 in a mouse model.
    Hearst SM, Shao Q, Lopez M, Raucher D, Vig PJ.
    Cerebellum; 2014 Oct 07; 13(5):596-606. PubMed ID: 24930030
    [Abstract] [Full Text] [Related]

  • 6. Glial S100B protein modulates mutant ataxin-1 aggregation and toxicity: TRTK12 peptide, a potential candidate for SCA1 therapy.
    Vig PJ, Hearst S, Shao Q, Lopez ME, Murphy HA, Safaya E.
    Cerebellum; 2011 Jun 07; 10(2):254-66. PubMed ID: 21384195
    [Abstract] [Full Text] [Related]

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  • 9. miR-19, miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis.
    Lee Y, Samaco RC, Gatchel JR, Thaller C, Orr HT, Zoghbi HY.
    Nat Neurosci; 2008 Oct 07; 11(10):1137-9. PubMed ID: 18758459
    [Abstract] [Full Text] [Related]

  • 10. Amino acids in a region of ataxin-1 outside of the polyglutamine tract influence the course of disease in SCA1 transgenic mice.
    Skinner PJ, Vierra-Green CA, Emamian E, Zoghbi HY, Orr HT.
    Neuromolecular Med; 2002 Oct 07; 1(1):33-42. PubMed ID: 12025814
    [Abstract] [Full Text] [Related]

  • 11. Recovery from polyglutamine-induced neurodegeneration in conditional SCA1 transgenic mice.
    Zu T, Duvick LA, Kaytor MD, Berlinger MS, Zoghbi HY, Clark HB, Orr HT.
    J Neurosci; 2004 Oct 06; 24(40):8853-61. PubMed ID: 15470152
    [Abstract] [Full Text] [Related]

  • 12. Partial loss of ataxin-1 function contributes to transcriptional dysregulation in spinocerebellar ataxia type 1 pathogenesis.
    Crespo-Barreto J, Fryer JD, Shaw CA, Orr HT, Zoghbi HY.
    PLoS Genet; 2010 Jul 08; 6(7):e1001021. PubMed ID: 20628574
    [Abstract] [Full Text] [Related]

  • 13. Beyond the glutamine expansion: influence of posttranslational modifications of ataxin-1 in the pathogenesis of spinocerebellar ataxia type 1.
    Ju H, Kokubu H, Lim J.
    Mol Neurobiol; 2014 Dec 08; 50(3):866-874. PubMed ID: 24752589
    [Abstract] [Full Text] [Related]

  • 14. SCA1-phosphorylation, a regulator of Ataxin-1 function and pathogenesis.
    Orr HT.
    Prog Neurobiol; 2012 Dec 08; 99(3):179-85. PubMed ID: 22531670
    [Abstract] [Full Text] [Related]

  • 15. Cerebellar Transcriptome Profiles of ATXN1 Transgenic Mice Reveal SCA1 Disease Progression and Protection Pathways.
    Ingram M, Wozniak EAL, Duvick L, Yang R, Bergmann P, Carson R, O'Callaghan B, Zoghbi HY, Henzler C, Orr HT.
    Neuron; 2016 Mar 16; 89(6):1194-1207. PubMed ID: 26948890
    [Abstract] [Full Text] [Related]

  • 16. Hsp70/Hsc70 regulates the effect phosphorylation has on stabilizing ataxin-1.
    Jorgensen ND, Andresen JM, Pitt JE, Swenson MA, Zoghbi HY, Orr HT.
    J Neurochem; 2007 Sep 16; 102(6):2040-2048. PubMed ID: 17540008
    [Abstract] [Full Text] [Related]

  • 17. The histone deacetylase HDAC3 is essential for Purkinje cell function, potentially complicating the use of HDAC inhibitors in SCA1.
    Venkatraman A, Hu YS, Didonna A, Cvetanovic M, Krbanjevic A, Bilesimo P, Opal P.
    Hum Mol Genet; 2014 Jul 15; 23(14):3733-45. PubMed ID: 24594842
    [Abstract] [Full Text] [Related]

  • 18. USP7, a ubiquitin-specific protease, interacts with ataxin-1, the SCA1 gene product.
    Hong S, Kim SJ, Ka S, Choi I, Kang S.
    Mol Cell Neurosci; 2002 Jun 15; 20(2):298-306. PubMed ID: 12093161
    [Abstract] [Full Text] [Related]

  • 19. Suppression of calbindin-D28k expression exacerbates SCA1 phenotype in a disease mouse model.
    Vig PJ, Wei J, Shao Q, Lopez ME, Halperin R, Gerber J.
    Cerebellum; 2012 Sep 15; 11(3):718-32. PubMed ID: 22076800
    [Abstract] [Full Text] [Related]

  • 20. Polyglutamine disease toxicity is regulated by Nemo-like kinase in spinocerebellar ataxia type 1.
    Ju H, Kokubu H, Todd TW, Kahle JJ, Kim S, Richman R, Chirala K, Orr HT, Zoghbi HY, Lim J.
    J Neurosci; 2013 May 29; 33(22):9328-36. PubMed ID: 23719801
    [Abstract] [Full Text] [Related]

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