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290 related items for PubMed ID: 20881478

  • 1. Sorafenib induces apoptosis in HL60 cells by inhibiting Src kinase-mediated STAT3 phosphorylation.
    Zhao W, Zhang T, Qu B, Wu X, Zhu X, Meng F, Gu Y, Shu Y, Shen Y, Sun Y, Xu Q.
    Anticancer Drugs; 2011 Jan; 22(1):79-88. PubMed ID: 20881478
    [Abstract] [Full Text] [Related]

  • 2. Role of RAF/MEK/ERK pathway, p-STAT-3 and Mcl-1 in sorafenib activity in human pancreatic cancer cell lines.
    Ulivi P, Arienti C, Amadori D, Fabbri F, Carloni S, Tesei A, Vannini I, Silvestrini R, Zoli W.
    J Cell Physiol; 2009 Jul; 220(1):214-21. PubMed ID: 19288493
    [Abstract] [Full Text] [Related]

  • 3. The multikinase inhibitor sorafenib induces apoptosis in highly imatinib mesylate-resistant bcr/abl+ human leukemia cells in association with signal transducer and activator of transcription 5 inhibition and myeloid cell leukemia-1 down-regulation.
    Rahmani M, Nguyen TK, Dent P, Grant S.
    Mol Pharmacol; 2007 Sep; 72(3):788-95. PubMed ID: 17595328
    [Abstract] [Full Text] [Related]

  • 4. Sorafenib induces growth arrest and apoptosis of human glioblastoma cells through the dephosphorylation of signal transducers and activators of transcription 3.
    Yang F, Brown C, Buettner R, Hedvat M, Starr R, Scuto A, Schroeder A, Jensen M, Jove R.
    Mol Cancer Ther; 2010 Apr; 9(4):953-62. PubMed ID: 20371721
    [Abstract] [Full Text] [Related]

  • 5. Sorafenib induces apoptosis specifically in cells expressing BCR/ABL by inhibiting its kinase activity to activate the intrinsic mitochondrial pathway.
    Kurosu T, Ohki M, Wu N, Kagechika H, Miura O.
    Cancer Res; 2009 May 01; 69(9):3927-36. PubMed ID: 19366808
    [Abstract] [Full Text] [Related]

  • 6. 8-benzyl-4-oxo-8-azabicyclo[3.2.1]oct-2-ene-6,7-dicarboxylic acid (SD-1008), a novel janus kinase 2 inhibitor, increases chemotherapy sensitivity in human ovarian cancer cells.
    Duan Z, Bradner J, Greenberg E, Mazitschek R, Foster R, Mahoney J, Seiden MV.
    Mol Pharmacol; 2007 Nov 01; 72(5):1137-45. PubMed ID: 17675586
    [Abstract] [Full Text] [Related]

  • 7. Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5.
    Liu L, Cao Y, Chen C, Zhang X, McNabola A, Wilkie D, Wilhelm S, Lynch M, Carter C.
    Cancer Res; 2006 Dec 15; 66(24):11851-8. PubMed ID: 17178882
    [Abstract] [Full Text] [Related]

  • 8. Inhibition of doxorubicin-induced autophagy in hepatocellular carcinoma Hep3B cells by sorafenib--the role of extracellular signal-regulated kinase counteraction.
    Manov I, Pollak Y, Broneshter R, Iancu TC.
    FEBS J; 2011 Sep 15; 278(18):3494-507. PubMed ID: 21790999
    [Abstract] [Full Text] [Related]

  • 9. Taiwan cobra cardiotoxin III inhibits Src kinase leading to apoptosis and cell cycle arrest of oral squamous cell carcinoma Ca9-22 cells.
    Chien CM, Chang SY, Lin KL, Chiu CC, Chang LS, Lin SR.
    Toxicon; 2010 Sep 15; 56(4):508-20. PubMed ID: 20493203
    [Abstract] [Full Text] [Related]

  • 10. The multikinase inhibitor Sorafenib induces apoptosis and sensitises endometrial cancer cells to TRAIL by different mechanisms.
    Llobet D, Eritja N, Yeramian A, Pallares J, Sorolla A, Domingo M, Santacana M, Gonzalez-Tallada FJ, Matias-Guiu X, Dolcet X.
    Eur J Cancer; 2010 Mar 15; 46(4):836-50. PubMed ID: 20071162
    [Abstract] [Full Text] [Related]

  • 11. Roles of activated Src and Stat3 signaling in melanoma tumor cell growth.
    Niu G, Bowman T, Huang M, Shivers S, Reintgen D, Daud A, Chang A, Kraker A, Jove R, Yu H.
    Oncogene; 2002 Oct 10; 21(46):7001-10. PubMed ID: 12370822
    [Abstract] [Full Text] [Related]

  • 12. Multikinase inhibitor sorafenib exerts cytocidal efficacy against Non-Hodgkin lymphomas associated with inhibition of MAPK14 and AKT phosphorylation.
    Chapuy B, Schuelper N, Panse M, Dohm A, Hand E, Schroers R, Truemper L, Wulf GG.
    Br J Haematol; 2011 Feb 10; 152(4):401-12. PubMed ID: 21689083
    [Abstract] [Full Text] [Related]

  • 13. Galiellalactone is a novel therapeutic candidate against hormone-refractory prostate cancer expressing activated Stat3.
    Hellsten R, Johansson M, Dahlman A, Dizeyi N, Sterner O, Bjartell A.
    Prostate; 2008 Feb 15; 68(3):269-80. PubMed ID: 18163422
    [Abstract] [Full Text] [Related]

  • 14. Naphtho[1,2-b]furan-4,5-dione disrupts Janus kinase-2 and induces apoptosis in breast cancer MDA-MB-231 cells.
    Lin KL, Su JC, Chien CM, Tseng CH, Chen YL, Chang LS, Lin SR.
    Toxicol In Vitro; 2010 Jun 15; 24(4):1158-67. PubMed ID: 20197088
    [Abstract] [Full Text] [Related]

  • 15. Embelin suppresses STAT3 signaling, proliferation, and survival of multiple myeloma via the protein tyrosine phosphatase PTEN.
    Heo JY, Kim HJ, Kim SM, Park KR, Park SY, Kim SW, Nam D, Jang HJ, Lee SG, Ahn KS, Kim SH, Shim BS, Choi SH, Ahn KS.
    Cancer Lett; 2011 Sep 01; 308(1):71-80. PubMed ID: 21565443
    [Abstract] [Full Text] [Related]

  • 16. Cell density dependent increase of constitutive signal transducers and activators of transcription 3 activity in melanoma cells is mediated by Janus kinases.
    Kreis S, Munz GA, Haan S, Heinrich PC, Behrmann I.
    Mol Cancer Res; 2007 Dec 01; 5(12):1331-41. PubMed ID: 18171991
    [Abstract] [Full Text] [Related]

  • 17. Coadministration of sorafenib with rottlerin potently inhibits cell proliferation and migration in human malignant glioma cells.
    Jane EP, Premkumar DR, Pollack IF.
    J Pharmacol Exp Ther; 2006 Dec 01; 319(3):1070-80. PubMed ID: 16959960
    [Abstract] [Full Text] [Related]

  • 18. Src family kinases promote AML cell survival through activation of signal transducers and activators of transcription (STAT).
    Ozawa Y, Williams AH, Estes ML, Matsushita N, Boschelli F, Jove R, List AF.
    Leuk Res; 2008 Jun 01; 32(6):893-903. PubMed ID: 18179820
    [Abstract] [Full Text] [Related]

  • 19. Abrogation of signal transducer and activator of transcription 3 reactivation after Src kinase inhibition results in synergistic antitumor effects.
    Johnson FM, Saigal B, Tran H, Donato NJ.
    Clin Cancer Res; 2007 Jul 15; 13(14):4233-44. PubMed ID: 17634553
    [Abstract] [Full Text] [Related]

  • 20. Sorafenib inhibits signal transducer and activator of transcription 3 signaling associated with growth arrest and apoptosis of medulloblastomas.
    Yang F, Van Meter TE, Buettner R, Hedvat M, Liang W, Kowolik CM, Mepani N, Mirosevich J, Nam S, Chen MY, Tye G, Kirschbaum M, Jove R.
    Mol Cancer Ther; 2008 Nov 15; 7(11):3519-26. PubMed ID: 19001435
    [Abstract] [Full Text] [Related]

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