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211 related items for PubMed ID: 20951759

  • 1. The cooked meat-derived mammary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine promotes invasive behaviour of breast cancer cells.
    Lauber SN, Gooderham NJ.
    Toxicology; 2011 Jan 11; 279(1-3):139-45. PubMed ID: 20951759
    [Abstract] [Full Text] [Related]

  • 2. The cooked meat-derived mammary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) elicits estrogenic-like microRNA responses in breast cancer cells.
    Papaioannou MD, Koufaris C, Gooderham NJ.
    Toxicol Lett; 2014 Aug 17; 229(1):9-16. PubMed ID: 24877718
    [Abstract] [Full Text] [Related]

  • 3. The cooked meat carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine activates the extracellular signal regulated kinase mitogen-activated protein kinase pathway.
    Creton SK, Zhu H, Gooderham NJ.
    Cancer Res; 2007 Dec 01; 67(23):11455-62. PubMed ID: 18056474
    [Abstract] [Full Text] [Related]

  • 4. The cooked food derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine is a potent oestrogen: a mechanistic basis for its tissue-specific carcinogenicity.
    Lauber SN, Ali S, Gooderham NJ.
    Carcinogenesis; 2004 Dec 01; 25(12):2509-17. PubMed ID: 15319301
    [Abstract] [Full Text] [Related]

  • 5. Carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rats: dose-response studies.
    Shirai T, Tamano S, Sano M, Masui T, Hasegawa R, Ito N.
    Princess Takamatsu Symp; 1995 Dec 01; 23():232-9. PubMed ID: 8844814
    [Abstract] [Full Text] [Related]

  • 6. Detection of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine-DNA adducts in normal breast tissues and risk of breast cancer.
    Zhu J, Chang P, Bondy ML, Sahin AA, Singletary SE, Takahashi S, Shirai T, Li D.
    Cancer Epidemiol Biomarkers Prev; 2003 Sep 01; 12(9):830-7. PubMed ID: 14504191
    [Abstract] [Full Text] [Related]

  • 7. Inhibition of cell death in human mammary epithelial cells by the cooked meat-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4, 5-b]pyridine.
    Venugopal M, Agarwal R, Callaway A, Schut HA, Snyderwine EG.
    Biochem Biophys Res Commun; 1999 Dec 09; 266(1):203-7. PubMed ID: 10581190
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  • 9. Ethanol potentiates the genotoxicity of the food-derived mammary carcinogen PhIP in human estrogen receptor-positive mammary cells: mechanistic support for lifestyle factors (cooked red meat and ethanol) associated with mammary cancer.
    Malik DE, David RM, Gooderham NJ.
    Arch Toxicol; 2018 Apr 09; 92(4):1639-1655. PubMed ID: 29362861
    [Abstract] [Full Text] [Related]

  • 10. The food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine activates S-phase checkpoint and apoptosis, and induces gene mutation in human lymphoblastoid TK6 cells.
    Zhu H, Boobis AR, Gooderham NJ.
    Cancer Res; 2000 Mar 01; 60(5):1283-9. PubMed ID: 10728688
    [Abstract] [Full Text] [Related]

  • 11. The dietary charred meat carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine acts as both a tumor initiator and promoter in the rat ventral prostate.
    Nakai Y, Nelson WG, De Marzo AM.
    Cancer Res; 2007 Feb 01; 67(3):1378-84. PubMed ID: 17264317
    [Abstract] [Full Text] [Related]

  • 12. Diallyl sulfide inhibits PhIP-induced DNA strand breaks in normal human breast epithelial cells.
    Wilson C, Aboyade-Cole A, Newell O, Darling-Reed S, Oriaku E, Thomas R.
    Oncol Rep; 2007 Apr 01; 17(4):807-11. PubMed ID: 17342319
    [Abstract] [Full Text] [Related]

  • 13. Allelic imbalance and altered expression of genes in chromosome 2q11-2q16 from rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
    Qiu C, Yu M, Shan L, Snyderwine EG.
    Oncogene; 2003 Feb 27; 22(8):1253-60. PubMed ID: 12606953
    [Abstract] [Full Text] [Related]

  • 14. Intra- and interindividual variability in systemic exposure in humans to 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline and 2-amino-1-methyl- 6-phenylimidazo[4,5-b]pyridine, carcinogens present in cooked beef.
    Lynch AM, Knize MG, Boobis AR, Gooderham NJ, Davies DS, Murray S.
    Cancer Res; 1992 Nov 15; 52(22):6216-23. PubMed ID: 1423264
    [Abstract] [Full Text] [Related]

  • 15. Increased risk of mammary carcinoma development following transplacental and trans-breast milk exposure to a food-derived carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), in Sprague-Dawley rats.
    Hasegawa R, Kimura J, Yaono M, Takahashi S, Kato T, Futakuchi M, Fukutake M, Fukutome K, Wakabayashi K, Sugimura T.
    Cancer Res; 1995 Oct 01; 55(19):4333-8. PubMed ID: 7671244
    [Abstract] [Full Text] [Related]

  • 16. Inflammation does not precede or accompany the induction of preneoplastic lesions in the colon of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-fed rats.
    Kühnel D, Taugner F, Scholtka B, Steinberg P.
    Arch Toxicol; 2009 Aug 01; 83(8):763-8. PubMed ID: 19212758
    [Abstract] [Full Text] [Related]

  • 17. PhIP carcinogenicity in breast cancer: computational and experimental evidence for competitive interactions with human estrogen receptor.
    Bennion BJ, Cosman M, Lightstone FC, Knize MG, Montgomery JL, Bennett LM, Felton JS, Kulp KS.
    Chem Res Toxicol; 2005 Oct 01; 18(10):1528-36. PubMed ID: 16533016
    [Abstract] [Full Text] [Related]

  • 18. Protection against 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine cytotoxicity and DNA adduct formation in human prostate by glutathione S-transferase P1.
    Nelson CP, Kidd LC, Sauvageot J, Isaacs WB, De Marzo AM, Groopman JD, Nelson WG, Kensler TW.
    Cancer Res; 2001 Jan 01; 61(1):103-9. PubMed ID: 11196146
    [Abstract] [Full Text] [Related]

  • 19. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induces genetic changes in murine intestinal tumours and cells with ApcMin mutation.
    Andreassen A, Vikse R, Mikalsen A, Adamovic T, Steffensen IL, Hjertholm H, Levan G, Alexander J.
    Mutat Res; 2006 Apr 30; 604(1-2):60-70. PubMed ID: 16574467
    [Abstract] [Full Text] [Related]

  • 20. Application of the Margin of Exposure (MOE) approach to substances in food that are genotoxic and carcinogenic: example: CAS No: 105650-23-5 PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine).
    Carthew P, DiNovi M, Setzer RW.
    Food Chem Toxicol; 2010 Jan 30; 48 Suppl 1():S98-105. PubMed ID: 20113859
    [Abstract] [Full Text] [Related]

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