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374 related items for PubMed ID: 20959468

  • 1. FTY720 (fingolimod) sensitizes prostate cancer cells to radiotherapy by inhibition of sphingosine kinase-1.
    Pchejetski D, Bohler T, Brizuela L, Sauer L, Doumerc N, Golzio M, Salunkhe V, Teissié J, Malavaud B, Waxman J, Cuvillier O.
    Cancer Res; 2010 Nov 01; 70(21):8651-61. PubMed ID: 20959468
    [Abstract] [Full Text] [Related]

  • 2. FTY720 induced Bcl-associated and Fas-independent apoptosis in human renal cancer cells in vitro and significantly reduced in vivo tumor growth in mouse xenograft.
    Ubai T, Azuma H, Kotake Y, Inamoto T, Takahara K, Ito Y, Kiyama S, Sakamoto T, Horie S, Muto S, Takahara S, Otsuki Y, Katsuoka Y.
    Anticancer Res; 2007 Nov 01; 27(1A):75-88. PubMed ID: 17352219
    [Abstract] [Full Text] [Related]

  • 3. Induction of apoptosis in human bladder cancer cells in vitro and in vivo caused by FTY720 treatment.
    Azuma H, Takahara S, Horie S, Muto S, Otsuki Y, Katsuoka Y.
    J Urol; 2003 Jun 01; 169(6):2372-7. PubMed ID: 12771800
    [Abstract] [Full Text] [Related]

  • 4. Sphingosine kinase-1 as a chemotherapy sensor in prostate adenocarcinoma cell and mouse models.
    Pchejetski D, Golzio M, Bonhoure E, Calvet C, Doumerc N, Garcia V, Mazerolles C, Rischmann P, Teissié J, Malavaud B, Cuvillier O.
    Cancer Res; 2005 Dec 15; 65(24):11667-75. PubMed ID: 16357178
    [Abstract] [Full Text] [Related]

  • 5. Suppression of androgen-independent prostate cancer cell aggressiveness by FTY720: validating Runx2 as a potential antimetastatic drug screening platform.
    Chua CW, Chiu YT, Yuen HF, Chan KW, Man K, Wang X, Ling MT, Wong YC.
    Clin Cancer Res; 2009 Jul 01; 15(13):4322-35. PubMed ID: 19509141
    [Abstract] [Full Text] [Related]

  • 6. FTY720, a synthetic compound from Isaria sinclairii, inhibits proliferation and induces apoptosis in pancreatic cancer cells.
    Shen Y, Cai M, Xia W, Liu J, Zhang Q, Xie H, Wang C, Wang X, Zheng S.
    Cancer Lett; 2007 Sep 08; 254(2):288-97. PubMed ID: 17462818
    [Abstract] [Full Text] [Related]

  • 7. Marked prevention of tumor growth and metastasis by a novel immunosuppressive agent, FTY720, in mouse breast cancer models.
    Azuma H, Takahara S, Ichimaru N, Wang JD, Itoh Y, Otsuki Y, Morimoto J, Fukui R, Hoshiga M, Ishihara T, Nonomura N, Suzuki S, Okuyama A, Katsuoka Y.
    Cancer Res; 2002 Mar 01; 62(5):1410-9. PubMed ID: 11888913
    [Abstract] [Full Text] [Related]

  • 8. Expression of sphingosine kinase 2 in synovial fibroblasts of rheumatoid arthritis contributing to apoptosis by a sphingosine analogue, FTY720.
    Kamada K, Arita N, Tsubaki T, Takubo N, Fujino T, Soga Y, Miyazaki T, Yamamoto H, Nose M.
    Pathol Int; 2009 Jun 01; 59(6):382-9. PubMed ID: 19490468
    [Abstract] [Full Text] [Related]

  • 9. Radiosensitization of hormone-refractory prostate cancer cells by gossypol treatment.
    Akagunduz O, Karaca B, Atmaca H, Uzunoglu S, Karabulut B, Sanli UA, Haydaroglu A, Uslu R.
    J BUON; 2010 Jun 01; 15(4):763-7. PubMed ID: 21229643
    [Abstract] [Full Text] [Related]

  • 10. FTY720, a fungus metabolite, inhibits invasion ability of androgen-independent prostate cancer cells through inactivation of RhoA-GTPase.
    Zhou C, Ling MT, Kin-Wah Lee T, Man K, Wang X, Wong YC.
    Cancer Lett; 2006 Feb 20; 233(1):36-47. PubMed ID: 16473668
    [Abstract] [Full Text] [Related]

  • 11. Sphingosine kinase 1 overexpression contributes to cetuximab resistance in human colorectal cancer models.
    Rosa R, Marciano R, Malapelle U, Formisano L, Nappi L, D'Amato C, D'Amato V, Damiano V, Marfè G, Del Vecchio S, Zannetti A, Greco A, De Stefano A, Carlomagno C, Veneziani BM, Troncone G, De Placido S, Bianco R.
    Clin Cancer Res; 2013 Jan 01; 19(1):138-47. PubMed ID: 23166225
    [Abstract] [Full Text] [Related]

  • 12. Sphingosine analog fingolimod (FTY720) increases radiation sensitivity of human breast cancer cells in vitro.
    Marvaso G, Barone A, Amodio N, Raimondi L, Agosti V, Altomare E, Scotti V, Lombardi A, Bianco R, Bianco C, Caraglia M, Tassone P, Tagliaferri P.
    Cancer Biol Ther; 2014 Jun 01; 15(6):797-805. PubMed ID: 24657936
    [Abstract] [Full Text] [Related]

  • 13. FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance.
    Yasui H, Hideshima T, Raje N, Roccaro AM, Shiraishi N, Kumar S, Hamasaki M, Ishitsuka K, Tai YT, Podar K, Catley L, Mitsiades CS, Richardson PG, Albert R, Brinkmann V, Chauhan D, Anderson KC.
    Cancer Res; 2005 Aug 15; 65(16):7478-84. PubMed ID: 16103102
    [Abstract] [Full Text] [Related]

  • 14. The sphingosine-1-phosphate analogue FTY720 reduces atherosclerosis in apolipoprotein E-deficient mice.
    Keul P, Tölle M, Lucke S, von Wnuck Lipinski K, Heusch G, Schuchardt M, van der Giet M, Levkau B.
    Arterioscler Thromb Vasc Biol; 2007 Mar 15; 27(3):607-13. PubMed ID: 17158351
    [Abstract] [Full Text] [Related]

  • 15. Selective cancer cell apoptosis induced by FTY720; evidence for a Bcl-dependent pathway and impairment in ERK activity.
    Azuma H, Horie S, Muto S, Otsuki Y, Matsumoto K, Morimoto J, Gotoh R, Okuyama A, Suzuki S, Katsuoka Y, Takahara S.
    Anticancer Res; 2003 Mar 15; 23(4):3183-93. PubMed ID: 12926052
    [Abstract] [Full Text] [Related]

  • 16. Sphingosine kinase 1 inhibition sensitizes hormone-resistant prostate cancer to docetaxel.
    Sauer L, Nunes J, Salunkhe V, Skalska L, Kohama T, Cuvillier O, Waxman J, Pchejetski D.
    Int J Cancer; 2009 Dec 01; 125(11):2728-36. PubMed ID: 19521959
    [Abstract] [Full Text] [Related]

  • 17. Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells.
    Nagaoka Y, Otsuki K, Fujita T, Uesato S.
    Biol Pharm Bull; 2008 Jun 01; 31(6):1177-81. PubMed ID: 18520051
    [Abstract] [Full Text] [Related]

  • 18. The immunosuppressant FTY720 inhibits tumor angiogenesis via the sphingosine 1-phosphate receptor 1.
    Schmid G, Guba M, Ischenko I, Papyan A, Joka M, Schrepfer S, Bruns CJ, Jauch KW, Heeschen C, Graeb C.
    J Cell Biochem; 2007 May 01; 101(1):259-70. PubMed ID: 17203465
    [Abstract] [Full Text] [Related]

  • 19. Sphingosine kinase 1 as a potential therapeutic target in epithelial ovarian cancer.
    Lee JW, Ryu JY, Yoon G, Jeon HK, Cho YJ, Choi JJ, Song SY, Do IG, Lee YY, Kim TJ, Choi CH, Kim BG, Bae DS.
    Int J Cancer; 2015 Jul 01; 137(1):221-9. PubMed ID: 25429856
    [Abstract] [Full Text] [Related]

  • 20. FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells.
    Berdyshev EV, Gorshkova I, Skobeleva A, Bittman R, Lu X, Dudek SM, Mirzapoiazova T, Garcia JG, Natarajan V.
    J Biol Chem; 2009 Feb 27; 284(9):5467-77. PubMed ID: 19119142
    [Abstract] [Full Text] [Related]

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