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110 related items for PubMed ID: 21036913

  • 1. Pharmacological characterization of KLYP961, a dual inhibitor of inducible and neuronal nitric-oxide synthases.
    Symons KT, Nguyen PM, Massari ME, Anzola JV, Staszewski LM, Wang L, Yazdani N, Dorow S, Muhammad J, Sablad M, Rozenkrants N, Bonefous C, Payne JE, Rix PJ, Shiau AK, Noble SA, Smith ND, Hassig CA, Zhang Y, Rao TS.
    J Pharmacol Exp Ther; 2011 Feb; 336(2):468-78. PubMed ID: 21036913
    [Abstract] [Full Text] [Related]

  • 2. Discovery of dual inducible/neuronal nitric oxide synthase (iNOS/nNOS) inhibitor development candidate 4-((2-cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one (KD7332) part 2: identification of a novel, potent, and selective series of benzimidazole-quinolinone iNOS/nNOS dimerization inhibitors that are orally active in pain models.
    Payne JE, Bonnefous C, Symons KT, Nguyen PM, Sablad M, Rozenkrants N, Zhang Y, Wang L, Yazdani N, Shiau AK, Noble SA, Rix P, Rao TS, Hassig CA, Smith ND.
    J Med Chem; 2010 Nov 11; 53(21):7739-55. PubMed ID: 20931971
    [Abstract] [Full Text] [Related]

  • 3. Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models.
    Bonnefous C, Payne JE, Roppe J, Zhuang H, Chen X, Symons KT, Nguyen PM, Sablad M, Rozenkrants N, Zhang Y, Wang L, Severance D, Walsh JP, Yazdani N, Shiau AK, Noble SA, Rix P, Rao TS, Hassig CA, Smith ND.
    J Med Chem; 2009 May 14; 52(9):3047-62. PubMed ID: 19374401
    [Abstract] [Full Text] [Related]

  • 4. KLYP956 is a non-imidazole-based orally active inhibitor of nitric-oxide synthase dimerization.
    Symons KT, Massari ME, Nguyen PM, Lee TT, Roppe J, Bonnefous C, Payne JE, Smith ND, Noble SA, Sablad M, Rozenkrants N, Zhang Y, Rao TS, Shiau AK, Hassig CA.
    Mol Pharmacol; 2009 Jul 14; 76(1):153-62. PubMed ID: 19364813
    [Abstract] [Full Text] [Related]

  • 5. The novel imidazopyridine 2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine (BYK191023) is a highly selective inhibitor of the inducible nitric-oxide synthase.
    Strub A, Ulrich WR, Hesslinger C, Eltze M, Fuchss T, Strassner J, Strand S, Lehner MD, Boer R.
    Mol Pharmacol; 2006 Jan 14; 69(1):328-37. PubMed ID: 16223957
    [Abstract] [Full Text] [Related]

  • 6. Pharmacological assessments of nitric oxide synthase isoforms and downstream diversity of NO signaling in the maintenance of thermal and mechanical hypersensitivity after peripheral nerve injury in mice.
    Tanabe M, Nagatani Y, Saitoh K, Takasu K, Ono H.
    Neuropharmacology; 2009 Mar 14; 56(3):702-8. PubMed ID: 19111753
    [Abstract] [Full Text] [Related]

  • 7. Phenylpyrrole derivatives as neural and inducible nitric oxide synthase (nNOS and iNOS) inhibitors.
    López Cara LC, Camacho ME, Carrión MD, Tapias V, Gallo MA, Escames G, Acuña-Castroviejo D, Espinosa A, Entrena A.
    Eur J Med Chem; 2009 Jun 14; 44(6):2655-66. PubMed ID: 19117642
    [Abstract] [Full Text] [Related]

  • 8. Specific inhibition of nitric oxide synthases at different time points in a murine model of pulmonary sepsis.
    Lange M, Hamahata A, Traber DL, Nakano Y, Traber LD, Enkhbaatar P.
    Biochem Biophys Res Commun; 2011 Jan 21; 404(3):877-81. PubMed ID: 21184738
    [Abstract] [Full Text] [Related]

  • 9. Chemopreventive properties of a selective inducible nitric oxide synthase inhibitor in colon carcinogenesis, administered alone or in combination with celecoxib, a selective cyclooxygenase-2 inhibitor.
    Rao CV, Indranie C, Simi B, Manning PT, Connor JR, Reddy BS.
    Cancer Res; 2002 Jan 01; 62(1):165-70. PubMed ID: 11782374
    [Abstract] [Full Text] [Related]

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  • 11. PPA250 [3-(2,4-difluorophenyl)-6-[2-[4-(1H-imidazol-1-ylmethyl) phenoxy]ethoxy]-2-phenylpyridine], a novel orally effective inhibitor of the dimerization of inducible nitric-oxide synthase, exhibits an anti-inflammatory effect in animal models of chronic arthritis.
    Ohtsuka M, Konno F, Honda H, Oikawa T, Ishikawa M, Iwase N, Isomae K, Ishii F, Hemmi H, Sato S.
    J Pharmacol Exp Ther; 2002 Oct 01; 303(1):52-7. PubMed ID: 12235232
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  • 13. Antinociceptive activity of the selective iNOS inhibitor AR-C102222 in rodent models of inflammatory, neuropathic and post-operative pain.
    LaBuda CJ, Koblish M, Tuthill P, Dolle RE, Little PJ.
    Eur J Pain; 2006 Aug 01; 10(6):505-12. PubMed ID: 16125426
    [Abstract] [Full Text] [Related]

  • 14. Identification and SAR of selective inducible nitric oxide synthase (iNOS) dimerization inhibitors.
    Gahman TC, Herbert MR, Lang H, Thayer A, Symons KT, Nguyen PM, Massari ME, Dozier S, Zhang Y, Sablad M, Rao TS, Noble SA, Shiau AK, Hassig CA.
    Bioorg Med Chem Lett; 2011 Nov 15; 21(22):6888-94. PubMed ID: 21986586
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  • 16. Peripheral antinociceptive effects of mu- and delta-opioid receptor agonists in NOS2 and NOS1 knockout mice during chronic inflammatory pain.
    Leánez S, Hervera A, Pol O.
    Eur J Pharmacol; 2009 Jan 05; 602(1):41-9. PubMed ID: 19041302
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  • 18. ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties. II. In vivo characterization in the rat.
    Kowaluk EA, Mikusa J, Wismer CT, Zhu CZ, Schweitzer E, Lynch JJ, Lee CH, Jiang M, Bhagwat SS, Gomtsyan A, McKie J, Cox BF, Polakowski J, Reinhart G, Williams M, Jarvis MF.
    J Pharmacol Exp Ther; 2000 Dec 05; 295(3):1165-74. PubMed ID: 11082454
    [Abstract] [Full Text] [Related]

  • 19. The anti-inflammatory effects of Pyrolae herba extract through the inhibition of the expression of inducible nitric oxide synthase (iNOS) and NO production.
    Lee MH, Lee JM, Jun SH, Lee SH, Kim NW, Lee JH, Ko NY, Mun SH, Kim BK, Lim BO, Choi DK, Choi WS.
    J Ethnopharmacol; 2007 May 30; 112(1):49-54. PubMed ID: 17395412
    [Abstract] [Full Text] [Related]

  • 20. Differences in inflammatory pain in nNOS-, iNOS- and eNOS-deficient mice.
    Boettger MK, Uceyler N, Zelenka M, Schmitt A, Reif A, Chen Y, Sommer C.
    Eur J Pain; 2007 Oct 30; 11(7):810-8. PubMed ID: 17395508
    [Abstract] [Full Text] [Related]

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