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Journal Abstract Search

86 related items for PubMed ID: 21041082

  • 1. Design of a novel class of biphenyl CETP inhibitors.
    Lu Z, Napolitano JB, Theberge A, Ali A, Hammond ML, Tan E, Tong X, Xu SS, Latham MJ, Peterson LB, Anderson MS, Eveland SS, Guo Q, Hyland SA, Milot DP, Chen Y, Sparrow CP, Wright SD, Sinclair PJ.
    Bioorg Med Chem Lett; 2010 Dec 15; 20(24):7469-72. PubMed ID: 21041082
    [Abstract] [Full Text] [Related]

  • 2. Biphenyl-4-ylcarbamoyl thiophene carboxylic acids as potent DHODH inhibitors.
    Leban J, Kralik M, Mies J, Baumgartner R, Gassen M, Tasler S.
    Bioorg Med Chem Lett; 2006 Jan 15; 16(2):267-70. PubMed ID: 16246558
    [Abstract] [Full Text] [Related]

  • 3. Chromanol derivatives--a novel class of CETP inhibitors.
    Vakalopoulos A, Schmeck C, Thutewohl M, Li V, Bischoff H, Lustig K, Weber O, Paulsen H, Elias H.
    Bioorg Med Chem Lett; 2011 Jan 01; 21(1):488-91. PubMed ID: 21084191
    [Abstract] [Full Text] [Related]

  • 4. 2-(4-carbonylphenyl)benzoxazole inhibitors of CETP: scaffold design and advancement in HDLc-raising efficacy.
    Sweis RF, Hunt JA, Kallashi F, Hammond ML, Chen Y, Eveland SS, Guo Q, Hyland SA, Milot DP, Cumiskey AM, Latham M, Rosa R, Peterson L, Sparrow CP, Wright SD, Anderson MS, Sinclair PJ.
    Bioorg Med Chem Lett; 2011 Mar 15; 21(6):1890-5. PubMed ID: 21147531
    [Abstract] [Full Text] [Related]

  • 5. SAR studies on the central phenyl ring of substituted biphenyl oxazolidinone-potent CETP inhibitors.
    Lu Z, Chen YH, Napolitano JB, Taylor G, Ali A, Hammond ML, Deng Q, Tan E, Tong X, Xu SS, Latham MJ, Peterson LB, Anderson MS, Eveland SS, Guo Q, Hyland SA, Milot DP, Chen Y, Sparrow CP, Wright SD, Sinclair PJ.
    Bioorg Med Chem Lett; 2012 Jan 01; 22(1):199-203. PubMed ID: 22142541
    [Abstract] [Full Text] [Related]

  • 6. 2-Arylbenzoxazoles as CETP inhibitors: raising HDL-C in cynoCETP transgenic mice.
    Kallashi F, Kim D, Kowalchick J, Park YJ, Hunt JA, Ali A, Smith CJ, Hammond ML, Pivnichny JV, Tong X, Xu SS, Anderson MS, Chen Y, Eveland SS, Guo Q, Hyland SA, Milot DP, Cumiskey AM, Latham M, Peterson LB, Rosa R, Sparrow CP, Wright SD, Sinclair PJ.
    Bioorg Med Chem Lett; 2011 Jan 01; 21(1):558-61. PubMed ID: 21094047
    [Abstract] [Full Text] [Related]

  • 7. Novel tetrahydrochinoline derived CETP inhibitors.
    Schmeck C, Gielen-Haertwig H, Vakalopoulos A, Bischoff H, Li V, Wirtz G, Weber O.
    Bioorg Med Chem Lett; 2010 Mar 01; 20(5):1740-3. PubMed ID: 20137927
    [Abstract] [Full Text] [Related]

  • 8. Design and synthesis of new tetrahydroquinolines derivatives as CETP inhibitors.
    Escribano A, Mateo AI, Martin de la Nava EM, Mayhugh DR, Cockerham SL, Beyer TP, Schmidt RJ, Cao G, Zhang Y, Jones TM, Borel AG, Sweetana SA, Cannady EA, Mantlo NB.
    Bioorg Med Chem Lett; 2012 Jun 01; 22(11):3671-5. PubMed ID: 22543028
    [Abstract] [Full Text] [Related]

  • 9. Synthesis and discovery of 2,3-dihydro-3,8-diphenylbenzo[1,4]oxazines as a novel class of potent cholesteryl ester transfer protein inhibitors.
    Wang A, Prouty CP, Pelton PD, Yong M, Demarest KT, Murray WV, Kuo GH.
    Bioorg Med Chem Lett; 2010 Feb 15; 20(4):1432-5. PubMed ID: 20089400
    [Abstract] [Full Text] [Related]

  • 10. 2D Quantitative structure-activity relationship studies on a series of cholesteryl ester transfer protein inhibitors.
    Castilho MS, Guido RV, Andricopulo AD.
    Bioorg Med Chem; 2007 Sep 15; 15(18):6242-52. PubMed ID: 17604633
    [Abstract] [Full Text] [Related]

  • 11. Design, synthesis and structure-activity-relationship of 1,5-tetrahydronaphthyridines as CETP inhibitors.
    Fernandez MC, Escribano A, Mateo AI, Parthasarathy S, Martin de la Nava EM, Wang X, Cockerham SL, Beyer TP, Schmidt RJ, Cao G, Zhang Y, Jones TM, Borel A, Sweetana SA, Cannady EA, Stephenson G, Frank S, Mantlo NB.
    Bioorg Med Chem Lett; 2012 May 01; 22(9):3056-62. PubMed ID: 22497761
    [Abstract] [Full Text] [Related]

  • 12. Diphenylpyridylethanamine (DPPE)-based aminoheterocycles as cholesteryl ester transfer protein inhibitors.
    Wang Y, Yang W, Finlay HJ, Harikrishnan LS, Jiang J, Kamau MG, Van Kirk K, Nirschl DS, Taylor DS, Chen AY, Yin X, Sleph PG, Yang RZ, Huang CS, Adam LP, Lawrence RM, Wexler RR, Salvati ME.
    Bioorg Med Chem Lett; 2014 Feb 01; 24(3):860-4. PubMed ID: 24424134
    [Abstract] [Full Text] [Related]

  • 13. Biphenyl-substituted oxazolidinones as cholesteryl ester transfer protein inhibitors: modifications of the oxazolidinone ring leading to the discovery of anacetrapib.
    Smith CJ, Ali A, Hammond ML, Li H, Lu Z, Napolitano J, Taylor GE, Thompson CF, Anderson MS, Chen Y, Eveland SS, Guo Q, Hyland SA, Milot DP, Sparrow CP, Wright SD, Cumiskey AM, Latham M, Peterson LB, Rosa R, Pivnichny JV, Tong X, Xu SS, Sinclair PJ.
    J Med Chem; 2011 Jul 14; 54(13):4880-95. PubMed ID: 21682257
    [Abstract] [Full Text] [Related]

  • 14. Niacin increases HDL by reducing hepatic expression and plasma levels of cholesteryl ester transfer protein in APOE*3Leiden.CETP mice.
    van der Hoorn JW, de Haan W, Berbée JF, Havekes LM, Jukema JW, Rensen PC, Princen HM.
    Arterioscler Thromb Vasc Biol; 2008 Nov 14; 28(11):2016-22. PubMed ID: 18669886
    [Abstract] [Full Text] [Related]

  • 15. Triphenylethanamine Derivatives as Cholesteryl Ester Transfer Protein Inhibitors: Discovery of N-[(1R)-1-(3-Cyclopropoxy-4-fluorophenyl)-1-[3-fluoro-5-(1,1,2,2-tetrafluoroethoxy)phenyl]-2-phenylethyl]-4-fluoro-3-(trifluoromethyl)benzamide (BMS-795311).
    Qiao JX, Wang TC, Adam LP, Chen AY, Taylor DS, Yang RZ, Zhuang S, Sleph PG, Li JP, Li D, Yin X, Chang M, Chen XQ, Shen H, Li J, Smith D, Wu DR, Leith L, Harikrishnan LS, Kamau MG, Miller MM, Bilder D, Rampulla R, Li YX, Xu C, Lawrence RM, Poss MA, Levesque P, Gordon DA, Huang CS, Finlay HJ, Wexler RR, Salvati ME.
    J Med Chem; 2015 Nov 25; 58(22):9010-26. PubMed ID: 26524347
    [Abstract] [Full Text] [Related]

  • 16. 2-Arylbenzoxazoles as CETP inhibitors: Substitution of the benzoxazole moiety.
    Smith CJ, Ali A, Chen L, Hammond ML, Anderson MS, Chen Y, Eveland SS, Guo Q, Hyland SA, Milot DP, Sparrow CP, Wright SD, Sinclair PJ.
    Bioorg Med Chem Lett; 2010 Jan 01; 20(1):346-9. PubMed ID: 19914065
    [Abstract] [Full Text] [Related]

  • 17. Design and synthesis of potent inhibitors of cholesteryl ester transfer protein (CETP) exploiting a 1,2,3,4-tetrahydroquinoline platform.
    Rano TA, Sieber-McMaster E, Pelton PD, Yang M, Demarest KT, Kuo GH.
    Bioorg Med Chem Lett; 2009 May 01; 19(9):2456-60. PubMed ID: 19339179
    [Abstract] [Full Text] [Related]

  • 18. Design, synthesis and biological evaluation of N,N-3-phenyl-3-benzylaminopropanamide derivatives as novel cholesteryl ester transfer protein inhibitor.
    Zhao D, Xie H, Bai C, Liu C, Hao C, Zhao S, Yuan H, Luo C, Wang J, Lin B, Zheng J, Cheng M.
    Bioorg Med Chem; 2016 Apr 15; 24(8):1589-97. PubMed ID: 27010500
    [Abstract] [Full Text] [Related]

  • 19. P3 SAR exploration of biphenyl carbamate based Legumain inhibitors.
    Higgins C, Bouazzaoui S, Gaddale K, D'Costa Z, Templeman A, O'Rourke M, Young A, Scott C, Harrison T, Mullan P, Williams R.
    Bioorg Med Chem Lett; 2014 Jun 01; 24(11):2521-4. PubMed ID: 24775305
    [Abstract] [Full Text] [Related]

  • 20. Selective CETP inhibition and PPARalpha agonism increase HDL cholesterol and reduce LDL cholesterol in human ApoB100/human CETP transgenic mice.
    Hansen MK, McVey MJ, White RF, Legos JJ, Brusq JM, Grillot DA, Issandou M, Barone FC.
    J Cardiovasc Pharmacol Ther; 2010 Jun 01; 15(2):196-202. PubMed ID: 20332533
    [Abstract] [Full Text] [Related]

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