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Journal Abstract Search

164 related items for PubMed ID: 21042745

  • 1. Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce cell cycle arrest and apoptosis in prostate cancer cells.
    Nathwani SM, Cloonan SM, Stronach M, Campiani G, Lawler M, Williams DC, Zisterer DM.
    Oncol Rep; 2010 Dec; 24(6):1499-507. PubMed ID: 21042745
    [Abstract] [Full Text] [Related]

  • 2. Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce apoptosis in multi-drug-resistant cancer cells.
    Nathwani SM, Butler S, Fayne D, McGovern NN, Sarkadi B, Meegan MJ, Lloyd DG, Campiani G, Lawler M, Williams DC, Zisterer DM.
    Cancer Chemother Pharmacol; 2010 Aug; 66(3):585-96. PubMed ID: 20020128
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  • 3. Identification of tubulin as the molecular target of proapoptotic pyrrolo-1,5-benzoxazepines.
    Mulligan JM, Greene LM, Cloonan S, Mc Gee MM, Onnis V, Campiani G, Fattorusso C, Lawler M, Williams DC, Zisterer DM.
    Mol Pharmacol; 2006 Jul; 70(1):60-70. PubMed ID: 16571652
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  • 4. BubR1 is required for a sustained mitotic spindle checkpoint arrest in human cancer cells treated with tubulin-targeting pyrrolo-1,5-benzoxazepines.
    Greene LM, Campiani G, Lawler M, Williams DC, Zisterer DM.
    Mol Pharmacol; 2008 Feb; 73(2):419-30. PubMed ID: 17991869
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  • 5. The novel pyrrolo-1,5-benzoxazepine, PBOX-6, synergistically enhances the apoptotic effects of carboplatin in drug sensitive and multidrug resistant neuroblastoma cells.
    Lennon JC, Bright SA, Carroll E, Butini S, Campiani G, O'Meara A, Williams DC, Zisterer DM.
    Biochem Pharmacol; 2014 Feb 15; 87(4):611-24. PubMed ID: 24406249
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  • 7. Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells.
    Fiore D, Proto MC, Pisanti S, Picardi P, Pagano Zottola AC, Butini S, Gemma S, Casagni A, Laezza C, Vitale M, Ligresti A, Di Marzo V, Zisterer DM, Nathwani S, Williams DC, Campiani G, Gazzerro P, Bifulco M.
    Cancer Biol Ther; 2016 Aug 02; 17(8):849-58. PubMed ID: 26392056
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  • 8. Involvement of AMP-activated protein kinase in mediating pyrrolo-1,5-benzoxazepine-induced apoptosis in neuroblastoma cells.
    Lennon JC, Butini S, Campiani G, O'Meara A, Williams DC, Zisterer DM.
    Invest New Drugs; 2016 Oct 02; 34(5):663-76. PubMed ID: 27334143
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  • 10. Dual targeting of tumour cells and host endothelial cells by novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines.
    Nathwani SM, Butler S, Meegan MJ, Campiani G, Lawler M, Williams DC, Zisterer DM.
    Cancer Chemother Pharmacol; 2010 Jan 02; 65(2):289-300. PubMed ID: 19479253
    [Abstract] [Full Text] [Related]

  • 11. The novel tubulin-targeting agent pyrrolo-1,5-benzoxazepine-15 induces apoptosis in poor prognostic subgroups of chronic lymphocytic leukemia.
    McElligott AM, Maginn EN, Greene LM, McGuckin S, Hayat A, Browne PV, Butini S, Campiani G, Catherwood MA, Vandenberghe E, Williams DC, Zisterer DM, Lawler M.
    Cancer Res; 2009 Nov 01; 69(21):8366-75. PubMed ID: 19826055
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  • 12. The pyrrolo-1,5-benzoxazepine, PBOX-6, inhibits the growth of breast cancer cells in vitro independent of estrogen receptor status and inhibits breast tumour growth in vivo.
    Greene LM, Fleeton M, Mulligan J, Gowda C, Sheahan BJ, Atkins GJ, Campiani G, Nacci V, Lawler M, Williams DC, Zisterer DM.
    Oncol Rep; 2005 Nov 01; 14(5):1357-63. PubMed ID: 16211309
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  • 13. STI-571 (imatinib mesylate) enhances the apoptotic efficacy of pyrrolo-1,5-benzoxazepine-6, a novel microtubule-targeting agent, in both STI-571-sensitive and -resistant Bcr-Abl-positive human chronic myeloid leukemia cells.
    Greene LM, Kelly L, Onnis V, Campiani G, Lawler M, Williams DC, Zisterer DM.
    J Pharmacol Exp Ther; 2007 Apr 01; 321(1):288-97. PubMed ID: 17202400
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  • 14. Novel pyrrolo-1,5-benzoxazepine compounds display significant activity against resistant chronic myeloid leukaemia cells in vitro, in ex vivo patient samples and in vivo.
    Bright SA, McElligott AM, O'Connell JW, O'Connor L, Carroll P, Campiani G, Deininger MW, Conneally E, Lawler M, Williams DC, Zisterer DM.
    Br J Cancer; 2010 May 11; 102(10):1474-82. PubMed ID: 20407438
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  • 15. The novel pyrrolo-1,5-benzoxazepine, PBOX-15, synergistically enhances the apoptotic efficacy of imatinib in gastrointestinal stromal tumours; suggested mechanism of action of PBOX-15.
    Kinsella P, Greene LM, Bright SA, Pollock JK, Butini S, Campiani G, Bauer S, Williams DC, Zisterer DM.
    Invest New Drugs; 2016 Apr 11; 34(2):159-67. PubMed ID: 26885657
    [Abstract] [Full Text] [Related]

  • 16. PBOX-15, a novel microtubule targeting agent, induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple myeloma cells.
    Maginn EN, Browne PV, Hayden P, Vandenberghe E, MacDonagh B, Evans P, Goodyer M, Tewari P, Campiani G, Butini S, Williams DC, Zisterer DM, Lawler MP, McElligott AM.
    Br J Cancer; 2011 Jan 18; 104(2):281-9. PubMed ID: 21179037
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  • 18. The microtubule targeting agent PBOX-15 inhibits integrin-mediated cell adhesion and induces apoptosis in acute lymphoblastic leukaemia cells.
    Lysaght J, Verma NK, Maginn EN, Ryan JM, Campiani G, Zisterer DM, Williams DC, Browne PV, Lawler MP, McElligott AM.
    Int J Oncol; 2013 Jan 18; 42(1):239-46. PubMed ID: 23135704
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  • 19. A new microtubule-targeting compound PBOX-15 inhibits T-cell migration via post-translational modifications of tubulin.
    Verma NK, Dempsey E, Conroy J, Olwell P, Mcelligott AM, Davies AM, Kelleher D, Butini S, Campiani G, Williams DC, Zisterer DM, Lawler M, Volkov Y.
    J Mol Med (Berl); 2008 Apr 18; 86(4):457-69. PubMed ID: 18270678
    [Abstract] [Full Text] [Related]

  • 20. Inhibition of late-stage autophagy synergistically enhances pyrrolo-1,5-benzoxazepine-6-induced apoptotic cell death in human colon cancer cells.
    Greene LM, Nolan DP, Regan-Komito D, Campiani G, Williams DC, Zisterer DM.
    Int J Oncol; 2013 Sep 18; 43(3):927-35. PubMed ID: 23799546
    [Abstract] [Full Text] [Related]

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