These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Journal Abstract Search

549 related items for PubMed ID: 21073877

  • 1. Inhibiting β-secretase activity in Alzheimer's disease cell models with single-chain antibodies specifically targeting APP.
    Boddapati S, Levites Y, Sierks MR.
    J Mol Biol; 2011 Jan 14; 405(2):436-47. PubMed ID: 21073877
    [Abstract] [Full Text] [Related]

  • 2. Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo.
    Hussain I, Hawkins J, Harrison D, Hille C, Wayne G, Cutler L, Buck T, Walter D, Demont E, Howes C, Naylor A, Jeffrey P, Gonzalez MI, Dingwall C, Michel A, Redshaw S, Davis JB.
    J Neurochem; 2007 Feb 14; 100(3):802-9. PubMed ID: 17156133
    [Abstract] [Full Text] [Related]

  • 3. Immunotherapy against APP beta-secretase cleavage site improves cognitive function and reduces neuroinflammation in Tg2576 mice without a significant effect on brain abeta levels.
    Rakover I, Arbel M, Solomon B.
    Neurodegener Dis; 2007 Feb 14; 4(5):392-402. PubMed ID: 17536186
    [Abstract] [Full Text] [Related]

  • 4. Purification and cloning of amyloid precursor protein beta-secretase from human brain.
    Sinha S, Anderson JP, Barbour R, Basi GS, Caccavello R, Davis D, Doan M, Dovey HF, Frigon N, Hong J, Jacobson-Croak K, Jewett N, Keim P, Knops J, Lieberburg I, Power M, Tan H, Tatsuno G, Tung J, Schenk D, Seubert P, Suomensaari SM, Wang S, Walker D, Zhao J, McConlogue L, John V.
    Nature; 1999 Dec 02; 402(6761):537-40. PubMed ID: 10591214
    [Abstract] [Full Text] [Related]

  • 5. Bispecific tandem single chain antibody simultaneously inhibits β-secretase and promotes α-secretase processing of AβPP.
    Boddapati S, Levites Y, Suryadi V, Kasturirangan S, Sierks MR.
    J Alzheimers Dis; 2012 Dec 02; 28(4):961-9. PubMed ID: 22156046
    [Abstract] [Full Text] [Related]

  • 6. Inhibition of amyloid precursor protein processing by beta-secretase through site-directed antibodies.
    Arbel M, Yacoby I, Solomon B.
    Proc Natl Acad Sci U S A; 2005 May 24; 102(21):7718-23. PubMed ID: 15894613
    [Abstract] [Full Text] [Related]

  • 7. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
    Martone RL, Zhou H, Atchison K, Comery T, Xu JZ, Huang X, Gong X, Jin M, Kreft A, Harrison B, Mayer SC, Aschmies S, Gonzales C, Zaleska MM, Riddell DR, Wagner E, Lu P, Sun SC, Sonnenberg-Reines J, Oganesian A, Adkins K, Leach MW, Clarke DW, Huryn D, Abou-Gharbia M, Magolda R, Bard J, Frick G, Raje S, Forlow SB, Balliet C, Burczynski ME, Reinhart PH, Wan HI, Pangalos MN, Jacobsen JS.
    J Pharmacol Exp Ther; 2009 Nov 24; 331(2):598-608. PubMed ID: 19671883
    [Abstract] [Full Text] [Related]

  • 8. Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets.
    Evin G, Zhu A, Holsinger RM, Masters CL, Li QX.
    J Neurosci Res; 2003 Nov 01; 74(3):386-92. PubMed ID: 14598315
    [Abstract] [Full Text] [Related]

  • 9. Lactacystin decreases amyloid-beta peptide production by inhibiting beta-secretase activity.
    Kienlen-Campard P, Feyt C, Huysseune S, de Diesbach P, N'Kuli F, Courtoy PJ, Octave JN.
    J Neurosci Res; 2006 Nov 01; 84(6):1311-22. PubMed ID: 16941495
    [Abstract] [Full Text] [Related]

  • 10. Inhibition of amyloid beta-peptide production by blockage of beta-secretase cleavage site of amyloid precursor protein.
    Na CH, Jeon SH, Zhang G, Olson GL, Chae CB.
    J Neurochem; 2007 Jun 01; 101(6):1583-95. PubMed ID: 17542811
    [Abstract] [Full Text] [Related]

  • 11. Decrease in brain soluble amyloid precursor protein β (sAPPβ) in Alzheimer's disease cortex.
    Wu G, Sankaranarayanan S, Hsieh SH, Simon AJ, Savage MJ.
    J Neurosci Res; 2011 Jun 01; 89(6):822-32. PubMed ID: 21433051
    [Abstract] [Full Text] [Related]

  • 12. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity.
    Yan R, Bienkowski MJ, Shuck ME, Miao H, Tory MC, Pauley AM, Brashier JR, Stratman NC, Mathews WR, Buhl AE, Carter DB, Tomasselli AG, Parodi LA, Heinrikson RL, Gurney ME.
    Nature; 1999 Dec 02; 402(6761):533-7. PubMed ID: 10591213
    [Abstract] [Full Text] [Related]

  • 13. Promising multifunctional anti-Alzheimer's dimer bis(7)-Cognitin acting as an activator of protein kinase C regulates activities of alpha-secretase and BACE-1 concurrently.
    Fu H, Dou J, Li W, Cui W, Mak S, Hu Q, Luo J, Lam CS, Pang Y, Youdim MB, Han Y.
    Eur J Pharmacol; 2009 Nov 25; 623(1-3):14-21. PubMed ID: 19765582
    [Abstract] [Full Text] [Related]

  • 14. BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein.
    Farzan M, Schnitzler CE, Vasilieva N, Leung D, Choe H.
    Proc Natl Acad Sci U S A; 2000 Aug 15; 97(17):9712-7. PubMed ID: 10931940
    [Abstract] [Full Text] [Related]

  • 15. Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes.
    Kinoshita A, Fukumoto H, Shah T, Whelan CM, Irizarry MC, Hyman BT.
    J Cell Sci; 2003 Aug 15; 116(Pt 16):3339-46. PubMed ID: 12829747
    [Abstract] [Full Text] [Related]

  • 16. A novel beta-site amyloid precursor protein cleaving enzyme (BACE) isoform regulated by nonsense-mediated mRNA decay and proteasome-dependent degradation.
    Tanahashi H, Tabira T.
    Neurosci Lett; 2007 Nov 27; 428(2-3):103-8. PubMed ID: 17961921
    [Abstract] [Full Text] [Related]

  • 17. In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.
    Sankaranarayanan S, Price EA, Wu G, Crouthamel MC, Shi XP, Tugusheva K, Tyler KX, Kahana J, Ellis J, Jin L, Steele T, Stachel S, Coburn C, Simon AJ.
    J Pharmacol Exp Ther; 2008 Mar 27; 324(3):957-69. PubMed ID: 18156464
    [Abstract] [Full Text] [Related]

  • 18. BACE1 inhibition reduces endogenous Abeta and alters APP processing in wild-type mice.
    Nishitomi K, Sakaguchi G, Horikoshi Y, Gray AJ, Maeda M, Hirata-Fukae C, Becker AG, Hosono M, Sakaguchi I, Minami SS, Nakajima Y, Li HF, Takeyama C, Kihara T, Ota A, Wong PC, Aisen PS, Kato A, Kinoshita N, Matsuoka Y.
    J Neurochem; 2006 Dec 27; 99(6):1555-63. PubMed ID: 17083447
    [Abstract] [Full Text] [Related]

  • 19. Proteasome-mediated degradation of the C-terminus of the Alzheimer's disease beta-amyloid protein precursor: effect of C-terminal truncation on production of beta-amyloid protein.
    Nunan J, Williamson NA, Hill AF, Sernee MF, Masters CL, Small DH.
    J Neurosci Res; 2003 Nov 01; 74(3):378-85. PubMed ID: 14598314
    [Abstract] [Full Text] [Related]

  • 20. Expression and activity of beta-site amyloid precursor protein cleaving enzyme in Alzheimer's disease.
    Johnston JA, Liu WW, Todd SA, Coulson DT, Murphy S, Irvine GB, Passmore AP.
    Biochem Soc Trans; 2005 Nov 01; 33(Pt 5):1096-100. PubMed ID: 16246054
    [Abstract] [Full Text] [Related]

    Page: [Next] [New Search]
    of 28.