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Journal Abstract Search

175 related items for PubMed ID: 21074294

  • 1. Receptor-dependent (RD) 3D-QSAR approach of a series of benzylpiperidine inhibitors of human acetylcholinesterase (HuAChE).
    Araújo JQ, de Brito MA, Hoelz LV, de Alencastro RB, Castro HC, Rodrigues CR, Albuquerque MG.
    Eur J Med Chem; 2011 Jan; 46(1):39-51. PubMed ID: 21074294
    [Abstract] [Full Text] [Related]

  • 2. A comparative molecular field analysis study of N-benzylpiperidines as acetylcholinesterase inhibitors.
    Tong W, Collantes ER, Chen Y, Welsh WJ.
    J Med Chem; 1996 Jan 19; 39(2):380-7. PubMed ID: 8558505
    [Abstract] [Full Text] [Related]

  • 3. Design and synthesis of N-benzylpiperidine-purine derivatives as new dual inhibitors of acetyl- and butyrylcholinesterase.
    Rodríguez-Franco MI, Fernández-Bachiller MI, Pérez C, Castro A, Martínez A.
    Bioorg Med Chem; 2005 Dec 15; 13(24):6795-802. PubMed ID: 16183292
    [Abstract] [Full Text] [Related]

  • 4. Development of 3D-QSAR Model for Acetylcholinesterase Inhibitors Using a Combination of Fingerprint, Molecular Docking, and Structure-Based Pharmacophore Approaches.
    Lee S, Barron MG.
    Toxicol Sci; 2015 Nov 15; 148(1):60-70. PubMed ID: 26202430
    [Abstract] [Full Text] [Related]

  • 5. Quinolone-benzylpiperidine derivatives as novel acetylcholinesterase inhibitor and antioxidant hybrids for Alzheimer disease.
    Pudlo M, Luzet V, Ismaïli L, Tomassoli I, Iutzeler A, Refouvelet B.
    Bioorg Med Chem; 2014 Apr 15; 22(8):2496-507. PubMed ID: 24657052
    [Abstract] [Full Text] [Related]

  • 6. Consensus superiority of the pharmacophore-based alignment, over maximum common substructure (MCS): 3D-QSAR studies on carbamates as acetylcholinesterase inhibitors.
    Chaudhaery SS, Roy KK, Saxena AK.
    J Chem Inf Model; 2009 Jun 15; 49(6):1590-601. PubMed ID: 19441865
    [Abstract] [Full Text] [Related]

  • 7. 3D QSAR studies of AChE inhibitors based on molecular docking scores and CoMFA.
    Akula N, Lecanu L, Greeson J, Papadopoulos V.
    Bioorg Med Chem Lett; 2006 Dec 15; 16(24):6277-80. PubMed ID: 17049234
    [Abstract] [Full Text] [Related]

  • 8. Quantifying ligand-receptor interactions for gorge-spanning acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.
    Martis EA, Chandarana RC, Shaikh MS, Ambre PK, D'Souza JS, Iyer KR, Coutinho EC, Nandan SR, Pissurlenkar RR.
    J Biomol Struct Dyn; 2015 Dec 15; 33(5):1107-25. PubMed ID: 24905476
    [Abstract] [Full Text] [Related]

  • 9. Ligand-based 3D-QSAR studies of physostigmine analogues as acetylcholinesterase inhibitors.
    Ul-Haq Z, Mahmood U, Jehangir B.
    Chem Biol Drug Des; 2009 Dec 15; 74(6):571-81. PubMed ID: 19843075
    [Abstract] [Full Text] [Related]

  • 10. An investigation of structurally diverse carbamates for acetylcholinesterase (AChE) inhibition using 3D-QSAR analysis.
    Roy KK, Dixit A, Saxena AK.
    J Mol Graph Model; 2008 Sep 15; 27(2):197-208. PubMed ID: 18515163
    [Abstract] [Full Text] [Related]

  • 11. Novel alkyl- and arylcarbamate derivatives with N-benzylpiperidine and N-benzylpiperazine moieties as cholinesterases inhibitors.
    Więckowska A, Bajda M, Guzior N, Malawska B.
    Eur J Med Chem; 2010 Dec 15; 45(12):5602-11. PubMed ID: 20926161
    [Abstract] [Full Text] [Related]

  • 12. The simulated binding of (+/-)-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]meth yl] -1H-inden-1-one hydrochloride (E2020) and related inhibitors to free and acylated acetylcholinesterases and corresponding structure-activity analyses.
    Inoue A, Kawai T, Wakita M, Iimura Y, Sugimoto H, Kawakami Y.
    J Med Chem; 1996 Oct 25; 39(22):4460-70. PubMed ID: 8893840
    [Abstract] [Full Text] [Related]

  • 13. Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Abeta1-42 aggregation for Alzheimer's disease therapeutics.
    Kwon YE, Park JY, No KT, Shin JH, Lee SK, Eun JS, Yang JH, Shin TY, Kim DK, Chae BS, Leem JY, Kim KH.
    Bioorg Med Chem; 2007 Oct 15; 15(20):6596-607. PubMed ID: 17681794
    [Abstract] [Full Text] [Related]

  • 14. The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design.
    Greenblatt HM, Guillou C, Guénard D, Argaman A, Botti S, Badet B, Thal C, Silman I, Sussman JL.
    J Am Chem Soc; 2004 Dec 01; 126(47):15405-11. PubMed ID: 15563167
    [Abstract] [Full Text] [Related]

  • 15. A combinatorial feature selection approach to describe the QSAR of dual site inhibitors of acetylcholinesterase.
    Asadabadi EB, Abdolmaleki P, Barkooie SM, Jahandideh S, Rezaei MA.
    Comput Biol Med; 2009 Dec 01; 39(12):1089-95. PubMed ID: 19854437
    [Abstract] [Full Text] [Related]

  • 16. Construction of the pharmacophore model of acetylcholinesterase inhibitor.
    Zhu Y, Tong XY, Zhao Y, Chen H, Jiang FC.
    Yao Xue Xue Bao; 2008 Mar 01; 43(3):267-76. PubMed ID: 18630262
    [Abstract] [Full Text] [Related]

  • 17. Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE.
    Alonso D, Dorronsoro I, Rubio L, Muñoz P, García-Palomero E, Del Monte M, Bidon-Chanal A, Orozco M, Luque FJ, Castro A, Medina M, Martínez A.
    Bioorg Med Chem; 2005 Dec 15; 13(24):6588-97. PubMed ID: 16230018
    [Abstract] [Full Text] [Related]

  • 18. Discovery of novel 2,6-disubstituted pyridazinone derivatives as acetylcholinesterase inhibitors.
    Xing W, Fu Y, Shi Z, Lu D, Zhang H, Hu Y.
    Eur J Med Chem; 2013 May 15; 63():95-103. PubMed ID: 23466605
    [Abstract] [Full Text] [Related]

  • 19. Synthesis and in vitro evaluation of N-alkyl-7-methoxytacrine hydrochlorides as potential cholinesterase inhibitors in Alzheimer disease.
    Korabecny J, Musilek K, Holas O, Binder J, Zemek F, Marek J, Pohanka M, Opletalova V, Dohnal V, Kuca K.
    Bioorg Med Chem Lett; 2010 Oct 15; 20(20):6093-5. PubMed ID: 20817518
    [Abstract] [Full Text] [Related]

  • 20. Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs.
    Kryger G, Silman I, Sussman JL.
    Structure; 1999 Mar 15; 7(3):297-307. PubMed ID: 10368299
    [Abstract] [Full Text] [Related]

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