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Journal Abstract Search

344 related items for PubMed ID: 21080725

  • 1. Synthesis and evaluation of azetidinone analogues of combretastatin A-4 as tubulin targeting agents.
    O'Boyle NM, Carr M, Greene LM, Bergin O, Nathwani SM, McCabe T, Lloyd DG, Zisterer DM, Meegan MJ.
    J Med Chem; 2010 Dec 23; 53(24):8569-84. PubMed ID: 21080725
    [Abstract] [Full Text] [Related]

  • 2. Lead identification of conformationally restricted β-lactam type combretastatin analogues: synthesis, antiproliferative activity and tubulin targeting effects.
    Carr M, Greene LM, Knox AJ, Lloyd DG, Zisterer DM, Meegan MJ.
    Eur J Med Chem; 2010 Dec 23; 45(12):5752-66. PubMed ID: 20933304
    [Abstract] [Full Text] [Related]

  • 3. Synthesis, evaluation and structural studies of antiproliferative tubulin-targeting azetidin-2-ones.
    O'Boyle NM, Greene LM, Bergin O, Fichet JB, McCabe T, Lloyd DG, Zisterer DM, Meegan MJ.
    Bioorg Med Chem; 2011 Apr 01; 19(7):2306-25. PubMed ID: 21397510
    [Abstract] [Full Text] [Related]

  • 4. Lead identification of conformationally restricted benzoxepin type combretastatin analogs: synthesis, antiproliferative activity, and tubulin effects.
    Barrett I, Carr M, O'Boyle N, Greene LM, Knox AJ, Lloyd DG, Zisterer DM, Meegan MJ.
    J Enzyme Inhib Med Chem; 2010 Apr 01; 25(2):180-94. PubMed ID: 20222762
    [Abstract] [Full Text] [Related]

  • 5. 2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents.
    Chang JY, Yang MF, Chang CY, Chen CM, Kuo CC, Liou JP.
    J Med Chem; 2006 Oct 19; 49(21):6412-5. PubMed ID: 17034147
    [Abstract] [Full Text] [Related]

  • 6. Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral β-lactam bridged combretastatin A-4 analogues as potent antitumor agents.
    Zhou P, Liang Y, Zhang H, Jiang H, Feng K, Xu P, Wang J, Wang X, Ding K, Luo C, Liu M, Wang Y.
    Eur J Med Chem; 2018 Jan 20; 144():817-842. PubMed ID: 29306206
    [Abstract] [Full Text] [Related]

  • 7. 1,5-Disubstituted 1,2,3-triazoles as cis-restricted analogues of combretastatin A-4: Synthesis, molecular modeling and evaluation as cytotoxic agents and inhibitors of tubulin.
    Odlo K, Hentzen J, dit Chabert JF, Ducki S, Gani OA, Sylte I, Skrede M, Flørenes VA, Hansen TV.
    Bioorg Med Chem; 2008 May 01; 16(9):4829-38. PubMed ID: 18396050
    [Abstract] [Full Text] [Related]

  • 8. Regioselective Suzuki coupling of dihaloheteroaromatic compounds as a rapid strategy to synthesize potent rigid combretastatin analogues.
    Theeramunkong S, Caldarelli A, Massarotti A, Aprile S, Caprioglio D, Zaninetti R, Teruggi A, Pirali T, Grosa G, Tron GC, Genazzani AA.
    J Med Chem; 2011 Jul 28; 54(14):4977-86. PubMed ID: 21696175
    [Abstract] [Full Text] [Related]

  • 9. Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents.
    Liou JP, Chang YL, Kuo FM, Chang CW, Tseng HY, Wang CC, Yang YN, Chang JY, Lee SJ, Hsieh HP.
    J Med Chem; 2004 Aug 12; 47(17):4247-57. PubMed ID: 15293996
    [Abstract] [Full Text] [Related]

  • 10. Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-41.
    Pettit GR, Rhodes MR, Herald DL, Hamel E, Schmidt JM, Pettit RK.
    J Med Chem; 2005 Jun 16; 48(12):4087-99. PubMed ID: 15943482
    [Abstract] [Full Text] [Related]

  • 11. Imidazolone-amide bridges and their effects on tubulin polymerization in cis-locked vinylogous combretastatin-A4 analogues: synthesis and biological evaluation.
    Li YW, Liu J, Liu N, Shi D, Zhou XT, Lv JG, Zhu J, Zheng CH, Zhou YJ.
    Bioorg Med Chem; 2011 Jun 01; 19(11):3579-84. PubMed ID: 21536450
    [Abstract] [Full Text] [Related]

  • 12. Synthesis and biological evaluation of 2-amino-3-(3',4',5'-trimethoxybenzoyl)-5-aryl thiophenes as a new class of potent antitubulin agents.
    Romagnoli R, Baraldi PG, Pavani MG, Tabrizi MA, Preti D, Fruttarolo F, Piccagli L, Jung MK, Hamel E, Borgatti M, Gambari R.
    J Med Chem; 2006 Jun 29; 49(13):3906-15. PubMed ID: 16789746
    [Abstract] [Full Text] [Related]

  • 13. Design, synthesis, and biological evaluation of thiophene analogues of chalcones.
    Romagnoli R, Baraldi PG, Carrion MD, Cara CL, Cruz-Lopez O, Preti D, Tolomeo M, Grimaudo S, Di Cristina A, Zonta N, Balzarini J, Brancale A, Sarkar T, Hamel E.
    Bioorg Med Chem; 2008 May 15; 16(10):5367-76. PubMed ID: 18440234
    [Abstract] [Full Text] [Related]

  • 14. Potent antitubulin tumor cell cytotoxins based on 3-aroyl indazoles.
    Duan JX, Cai X, Meng F, Lan L, Hart C, Matteucci M.
    J Med Chem; 2007 Mar 08; 50(5):1001-6. PubMed ID: 17286393
    [Abstract] [Full Text] [Related]

  • 15. Synthesis and antitumor activity of benzils related to combretastatin A-4.
    Mousset C, Giraud A, Provot O, Hamze A, Bignon J, Liu JM, Thoret S, Dubois J, Brion JD, Alami M.
    Bioorg Med Chem Lett; 2008 Jun 01; 18(11):3266-71. PubMed ID: 18477509
    [Abstract] [Full Text] [Related]

  • 16. Examination of the 1,4-disubstituted azetidinone ring system as a template for combretastatin A-4 conformationally restricted analogue design.
    Sun L, Vasilevich NI, Fuselier JA, Hocart SJ, Coy DH.
    Bioorg Med Chem Lett; 2004 May 03; 14(9):2041-6. PubMed ID: 15080975
    [Abstract] [Full Text] [Related]

  • 17. Design, synthesis, and biological evaluation of novel combretastatin A-4 thio derivatives as microtubule targeting agents.
    Stefański T, Mikstacka R, Kurczab R, Dutkiewicz Z, Kucińska M, Murias M, Zielińska-Przyjemska M, Cichocki M, Teubert A, Kaczmarek M, Hogendorf A, Sobiak S.
    Eur J Med Chem; 2018 Jan 20; 144():797-816. PubMed ID: 29291446
    [Abstract] [Full Text] [Related]

  • 18. 2-amino-3,4,5-trimethoxybenzophenones as potent tubulin polymerization inhibitors.
    Chuang HY, Chang JY, Lai MJ, Kuo CC, Lee HY, Hsieh HP, Chen YJ, Chen LT, Pan WY, Liou JP.
    ChemMedChem; 2011 Mar 07; 6(3):450-6. PubMed ID: 21360819
    [Abstract] [Full Text] [Related]

  • 19. Synthesis and evaluation of 4/5-hydroxy-2,3-diaryl(substituted)-cyclopent-2-en-1-ones as cis-restricted analogues of combretastatin A-4 as novel anticancer agents.
    Gurjar MK, Wakharkar RD, Singh AT, Jaggi M, Borate HB, Shinde PD, Verma R, Rajendran P, Dutt S, Singh G, Sanna VK, Singh MK, Srivastava SK, Mahajan VA, Jadhav VH, Dutta K, Krishnan K, Chaudhary A, Agarwal SK, Mukherjee R, Burman AC.
    J Med Chem; 2007 Apr 19; 50(8):1744-53. PubMed ID: 17373779
    [Abstract] [Full Text] [Related]

  • 20. Isoxazole-type derivatives related to combretastatin A-4, synthesis and biological evaluation.
    Kaffy J, Pontikis R, Carrez D, Croisy A, Monneret C, Florent JC.
    Bioorg Med Chem; 2006 Jun 15; 14(12):4067-77. PubMed ID: 16510288
    [Abstract] [Full Text] [Related]

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