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154 related items for PubMed ID: 2110815

  • 1. The effects of three bioreductive drugs (mitomycin C, RSU-1069 and SR4233) on cell lines selected for their sensitivity to mitomycin C or ionising radiation.
    Keohane A, Godden J, Stratford IJ, Adams GE.
    Br J Cancer; 1990 May; 61(5):722-6. PubMed ID: 2110815
    [Abstract] [Full Text] [Related]

  • 2. The effect of low pH and hypoxia on the cytotoxic effects of SR4233 and mitomycin C in vitro.
    Skarsgard LD, Vinczan A, Skwarchuk MW, Chaplin DJ.
    Int J Radiat Oncol Biol Phys; 1994 May 15; 29(2):363-7. PubMed ID: 8195034
    [Abstract] [Full Text] [Related]

  • 3. The differential hypoxic cytotoxicity of bioreductive agents determined in vitro by the MTT assay.
    Stratford IJ, Stephens MA.
    Int J Radiat Oncol Biol Phys; 1989 Apr 15; 16(4):973-6. PubMed ID: 2495261
    [Abstract] [Full Text] [Related]

  • 4. Overexpression of human NADPH:cytochrome c (P450) reductase confers enhanced sensitivity to both tirapazamine (SR 4233) and RSU 1069.
    Patterson AV, Saunders MP, Chinje EC, Talbot DC, Harris AL, Strafford IJ.
    Br J Cancer; 1997 Apr 15; 76(10):1338-47. PubMed ID: 9374381
    [Abstract] [Full Text] [Related]

  • 5. Decreased NADPH:cytochrome P-450 reductase activity and impaired drug activation in a mammalian cell line resistant to mitomycin C under aerobic but not hypoxic conditions.
    Hoban PR, Walton MI, Robson CN, Godden J, Stratford IJ, Workman P, Harris AL, Hickson ID.
    Cancer Res; 1990 Aug 01; 50(15):4692-7. PubMed ID: 2114946
    [Abstract] [Full Text] [Related]

  • 6. Unusual oxygen concentration dependence of toxicity of SR-4233, a hypoxic cell toxin.
    Koch CJ.
    Cancer Res; 1993 Sep 01; 53(17):3992-7. PubMed ID: 8358728
    [Abstract] [Full Text] [Related]

  • 7. Bioreductive drugs and the selective induction of tumour hypoxia.
    Bremner JC, Stratford IJ, Bowler J, Adams GE.
    Br J Cancer; 1990 May 01; 61(5):717-21. PubMed ID: 2110814
    [Abstract] [Full Text] [Related]

  • 8. Enhancement of DNA damage in mammalian cells upon bioreduction of the nitroimidazole-aziridines RSU-1069 and RSU-1131.
    Jenner TJ, Sapora O, O'Neill P, Fielden EM.
    Biochem Pharmacol; 1988 Oct 15; 37(20):3837-42. PubMed ID: 3190731
    [Abstract] [Full Text] [Related]

  • 9. Studies on the toxicity of RSU-1069.
    Whitmore GF, Gulyas S.
    Int J Radiat Oncol Biol Phys; 1986 Jul 15; 12(7):1219-22. PubMed ID: 3755716
    [Abstract] [Full Text] [Related]

  • 10. Use of the comet assay to detect hypoxic cells in murine tumours and normal tissues exposed to bioreductive drugs.
    Olive PL.
    Acta Oncol; 1995 Jul 15; 34(3):301-5. PubMed ID: 7779413
    [Abstract] [Full Text] [Related]

  • 11. Effect of deficiencies in DNA repair on the toxicity of mitomycin C and porfiromycin to CHO cells under aerobic and hypoxic conditions.
    Hughes CS, Irvin CG, Rockwell S.
    Cancer Commun; 1991 Feb 15; 3(2):29-35. PubMed ID: 1899798
    [Abstract] [Full Text] [Related]

  • 12. Studies with bifunctional bioreductive drugs. II. Cytotoxicity assayed with A-549 lung carcinoma cells of human origin.
    Roizin-Towle L, Pirro JP, Hall EJ.
    Radiat Res; 1990 Oct 15; 124(1 Suppl):S50-5. PubMed ID: 2236511
    [Abstract] [Full Text] [Related]

  • 13. Assessment of micronucleus induction in SCCVII cells treated with bioreductive agents, WIN 59075 (SR 4233) and mitomycin C, under aerobic and hypoxic conditions.
    Shibata T, Shibamoto Y, Sasai K, Oya N, Takagi T, Murata R, Abe M.
    Mutat Res; 1995 Apr 15; 342(3-4):171-7. PubMed ID: 7715618
    [Abstract] [Full Text] [Related]

  • 14. Evaluation of bioreductive drugs in multicell spheroids.
    Durand RE, Olive PL.
    Int J Radiat Oncol Biol Phys; 1992 Apr 15; 22(4):689-92. PubMed ID: 1544838
    [Abstract] [Full Text] [Related]

  • 15. Studies on the mechanisms of the radiosensitizing and cytotoxic properties of RSU-1069 and its analogues.
    Walling JM, Stratford IJ, Adams GE, Silver AR, Ahmed I, Jenkins TC, Fielden EM.
    Int J Radiat Oncol Biol Phys; 1986 Jul 15; 12(7):1083-6. PubMed ID: 3755712
    [Abstract] [Full Text] [Related]

  • 16. Modulation of sensitivity to mitomycin C and a dithiol analogue by tempol in non-small-cell lung cancer cell lines under hypoxia.
    Bando T, Kasahara K, Shibata K, Numata Y, Heki U, Shirasaki H, Iwasa K, Fujimura M, Matsuda T.
    J Cancer Res Clin Oncol; 1996 Jul 15; 122(1):21-6. PubMed ID: 8543588
    [Abstract] [Full Text] [Related]

  • 17. Cytotoxicity of RSU 1069 in spheroids and murine tumors.
    Olive PL, Durand RE, Chaplin DJ.
    Int J Radiat Oncol Biol Phys; 1987 Sep 15; 13(9):1361-6. PubMed ID: 3624045
    [Abstract] [Full Text] [Related]

  • 18. Induction of mutations in V79-4 mammalian cells under hypoxic and aerobic conditions by the cytotoxic 2-nitroimidazole-aziridines, RSU-1069 and RSU-1131. The influence of cellular glutathione.
    Sapora O, Paone A, Maggi A, Jenner TJ, O'Neill P.
    Biochem Pharmacol; 1992 Oct 06; 44(7):1341-7. PubMed ID: 1417957
    [Abstract] [Full Text] [Related]

  • 19. Cytotoxicity and DNA lesions produced by mitomycin C and porfiromycin in hypoxic and aerobic EMT6 and Chinese hamster ovary cells.
    Fracasso PM, Sartorelli AC.
    Cancer Res; 1986 Aug 06; 46(8):3939-44. PubMed ID: 3089583
    [Abstract] [Full Text] [Related]

  • 20. Characterization of a set of Chinese hamster ovary variant cell lines demonstrating differing sensitivity to mitomycin C.
    Kuehl BL, Buchwald M, Rauth AM.
    Oncol Res; 1993 Aug 06; 5(6-7):213-21. PubMed ID: 8123941
    [Abstract] [Full Text] [Related]

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