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330 related items for PubMed ID: 21114978

  • 1. Metformin reduces cisplatin-mediated apoptotic death of cancer cells through AMPK-independent activation of Akt.
    Janjetovic K, Vucicevic L, Misirkic M, Vilimanovich U, Tovilovic G, Zogovic N, Nikolic Z, Jovanovic S, Bumbasirevic V, Trajkovic V, Harhaji-Trajkovic L.
    Eur J Pharmacol; 2011 Jan 25; 651(1-3):41-50. PubMed ID: 21114978
    [Abstract] [Full Text] [Related]

  • 2. In vitro and in vivo anti-melanoma action of metformin.
    Janjetovic K, Harhaji-Trajkovic L, Misirkic-Marjanovic M, Vucicevic L, Stevanovic D, Zogovic N, Sumarac-Dumanovic M, Micic D, Trajkovic V.
    Eur J Pharmacol; 2011 Oct 15; 668(3):373-82. PubMed ID: 21806981
    [Abstract] [Full Text] [Related]

  • 3. Indomethacin induces apoptosis in 786-O renal cell carcinoma cells by activating mitogen-activated protein kinases and AKT.
    Ou YC, Yang CR, Cheng CL, Raung SL, Hung YY, Chen CJ.
    Eur J Pharmacol; 2007 Jun 01; 563(1-3):49-60. PubMed ID: 17341418
    [Abstract] [Full Text] [Related]

  • 4. Heat shock protein 27 protects L929 cells from cisplatin-induced apoptosis by enhancing Akt activation and abating suppression of thioredoxin reductase activity.
    Zhang Y, Shen X.
    Clin Cancer Res; 2007 May 15; 13(10):2855-64. PubMed ID: 17504983
    [Abstract] [Full Text] [Related]

  • 5. Metformin amplifies chemotherapy-induced AMPK activation and antitumoral growth.
    Rocha GZ, Dias MM, Ropelle ER, Osório-Costa F, Rossato FA, Vercesi AE, Saad MJ, Carvalheira JB.
    Clin Cancer Res; 2011 Jun 15; 17(12):3993-4005. PubMed ID: 21543517
    [Abstract] [Full Text] [Related]

  • 6. Metformin and the mTOR inhibitor everolimus (RAD001) sensitize breast cancer cells to the cytotoxic effect of chemotherapeutic drugs in vitro.
    Liu H, Scholz C, Zang C, Schefe JH, Habbel P, Regierer AC, Schulz CO, Possinger K, Eucker J.
    Anticancer Res; 2012 May 15; 32(5):1627-37. PubMed ID: 22593441
    [Abstract] [Full Text] [Related]

  • 7. Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells.
    Zakikhani M, Blouin MJ, Piura E, Pollak MN.
    Breast Cancer Res Treat; 2010 Aug 15; 123(1):271-9. PubMed ID: 20135346
    [Abstract] [Full Text] [Related]

  • 8. Metformin enhances cisplatin cytotoxicity by suppressing signal transducer and activator of transcription-3 activity independently of the liver kinase B1-AMP-activated protein kinase pathway.
    Lin CC, Yeh HH, Huang WL, Yan JJ, Lai WW, Su WP, Chen HH, Su WC.
    Am J Respir Cell Mol Biol; 2013 Aug 15; 49(2):241-50. PubMed ID: 23526220
    [Abstract] [Full Text] [Related]

  • 9. Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway.
    Vucicevic L, Misirkic M, Janjetovic K, Vilimanovich U, Sudar E, Isenovic E, Prica M, Harhaji-Trajkovic L, Kravic-Stevovic T, Bumbasirevic V, Trajkovic V.
    Autophagy; 2011 Jan 15; 7(1):40-50. PubMed ID: 20980833
    [Abstract] [Full Text] [Related]

  • 10. Failure of activation of caspase-9 induces a higher threshold for apoptosis and cisplatin resistance in testicular cancer.
    Mueller T, Voigt W, Simon H, Fruehauf A, Bulankin A, Grothey A, Schmoll HJ.
    Cancer Res; 2003 Jan 15; 63(2):513-21. PubMed ID: 12543810
    [Abstract] [Full Text] [Related]

  • 11. Metformin prevents endoplasmic reticulum stress-induced apoptosis through AMPK-PI3K-c-Jun NH2 pathway.
    Jung TW, Lee MW, Lee YJ, Kim SM.
    Biochem Biophys Res Commun; 2012 Jan 06; 417(1):147-52. PubMed ID: 22138650
    [Abstract] [Full Text] [Related]

  • 12. Metformin prevents an adaptive increase in GSH and induces apoptosis under the conditions of GSH deficiency in H4IIE cells.
    Bae EJ, Cho MJ, Kim SG.
    J Toxicol Environ Health A; 2007 Aug 06; 70(15-16):1371-80. PubMed ID: 17654257
    [Abstract] [Full Text] [Related]

  • 13. The altered apoptotic pathways in cisplatin and etoposide-resistant melanoma cells are drug specific.
    Kissel CK, Schadendorf D, Röckmann H.
    Melanoma Res; 2006 Dec 06; 16(6):527-35. PubMed ID: 17119454
    [Abstract] [Full Text] [Related]

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  • 15. Human melanoma cells selected for resistance to apoptosis by prolonged exposure to tumor necrosis factor-related apoptosis-inducing ligand are more vulnerable to necrotic cell death induced by cisplatin.
    Zhang XD, Wu JJ, Gillespie S, Borrow J, Hersey P.
    Clin Cancer Res; 2006 Feb 15; 12(4):1355-64. PubMed ID: 16489094
    [Abstract] [Full Text] [Related]

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  • 17. Human bladder cancer cells undergo cisplatin-induced apoptosis that is associated with p53-dependent and p53-independent responses.
    Konstantakou EG, Voutsinas GE, Karkoulis PK, Aravantinos G, Margaritis LH, Stravopodis DJ.
    Int J Oncol; 2009 Aug 15; 35(2):401-16. PubMed ID: 19578756
    [Abstract] [Full Text] [Related]

  • 18. Metformin-induced stimulation of AMP-activated protein kinase in beta-cells impairs their glucose responsiveness and can lead to apoptosis.
    Kefas BA, Cai Y, Kerckhofs K, Ling Z, Martens G, Heimberg H, Pipeleers D, Van de Casteele M.
    Biochem Pharmacol; 2004 Aug 01; 68(3):409-16. PubMed ID: 15242807
    [Abstract] [Full Text] [Related]

  • 19. Akt-mediated cisplatin resistance in ovarian cancer: modulation of p53 action on caspase-dependent mitochondrial death pathway.
    Yang X, Fraser M, Moll UM, Basak A, Tsang BK.
    Cancer Res; 2006 Mar 15; 66(6):3126-36. PubMed ID: 16540663
    [Abstract] [Full Text] [Related]

  • 20. Characterization of cell death events induced by anti-neoplastic drugs cisplatin, paclitaxel and 5-fluorouracil on human hepatoma cell lines: Possible mechanisms of cell resistance.
    Brenes O, Arce F, Gätjens-Boniche O, Díaz C.
    Biomed Pharmacother; 2007 Jul 15; 61(6):347-55. PubMed ID: 17399942
    [Abstract] [Full Text] [Related]

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