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PUBMED FOR HANDHELDS

Journal Abstract Search

217 related items for PubMed ID: 21134749

  • 61. Synthesis and structure-affinity relationships of 1-[omega-(4-aryl-1-piperazinyl)alkyl]-1-aryl ketones as 5-HT(7) receptor ligands.
    Perrone R, Berardi F, Colabufo NA, Lacivita E, Leopoldo M, Tortorella V.
    J Med Chem; 2003 Feb 13; 46(4):646-9. PubMed ID: 12570387
    [Abstract] [Full Text] [Related]

  • 62. Fluorination of 3-(3-(piperidin-1-yl)propyl)indoles and 3-(3-(piperazin-1-yl)propyl)indoles gives selective human 5-HT1D receptor ligands with improved pharmacokinetic profiles.
    van Niel MB, Collins I, Beer MS, Broughton HB, Cheng SK, Goodacre SC, Heald A, Locker KL, MacLeod AM, Morrison D, Moyes CR, O'Connor D, Pike A, Rowley M, Russell MG, Sohal B, Stanton JA, Thomas S, Verrier H, Watt AP, Castro JL.
    J Med Chem; 1999 Jun 17; 42(12):2087-104. PubMed ID: 10377215
    [Abstract] [Full Text] [Related]

  • 63. Correlating efficacy in rodent cognition models with in vivo 5-hydroxytryptamine1a receptor occupancy by a novel antagonist, (R)-N-(2-methyl-(4-indolyl-1-piperazinyl)ethyl)-N-(2-pyridinyl)-cyclohexane carboxamide (WAY-101405).
    Hirst WD, Andree TH, Aschmies S, Childers WE, Comery TA, Dawson LA, Day M, Feingold IB, Grauer SM, Harrison BL, Hughes ZA, Kao J, Kelly MG, van der Lee H, Rosenzweig-Lipson S, Saab AL, Smith DL, Sullivan K, Rizzo SJ, Tio C, Zhang MY, Schechter LE.
    J Pharmacol Exp Ther; 2008 Apr 17; 325(1):134-45. PubMed ID: 18182558
    [Abstract] [Full Text] [Related]

  • 64. 3-(Piperazinylpropyl)indoles: selective, orally bioavailable h5-HT1D receptor agonists as potential antimigraine agents.
    Chambers MS, Street LJ, Goodacre S, Hobbs SC, Hunt P, Jelley RA, Matassa VG, Reeve AJ, Sternfeld F, Beer MS, Stanton JA, Rathbone D, Watt AP, MacLeod AM.
    J Med Chem; 1999 Feb 25; 42(4):691-705. PubMed ID: 10052976
    [Abstract] [Full Text] [Related]

  • 65. Novel and selective 5-HT2C/2B receptor antagonists as potential anxiolytic agents: synthesis, quantitative structure-activity relationships, and molecular modeling of substituted 1-(3-pyridylcarbamoyl)indolines.
    Bromidge SM, Dabbs S, Davies DT, Duckworth DM, Forbes IT, Ham P, Jones GE, King FD, Saunders DV, Starr S, Thewlis KM, Wyman PA, Blaney FE, Naylor CB, Bailey F, Blackburn TP, Holland V, Kennett GA, Riley GJ, Wood MD.
    J Med Chem; 1998 May 07; 41(10):1598-612. PubMed ID: 9572885
    [Abstract] [Full Text] [Related]

  • 66. Structure-activity relationship studies of CNS agents. Part 24: New analogs of N-tert.-butyl-3-[4-(2-methoxyphenyl)-1-piperazinyl]-2-phenylpropanamide (WAY-100135).
    Boksa J, Klodzińska A, Charakchieva-Minol S, Chojnacka-Wójcik E, Mokrosz JL.
    Pharmazie; 1996 Feb 07; 51(2):72-6. PubMed ID: 8720802
    [Abstract] [Full Text] [Related]

  • 67. 3-(4-Fluoropiperidin-3-yl)-2-phenylindoles as high affinity, selective, and orally bioavailable h5-HT(2A) receptor antagonists.
    Rowley M, Hallett DJ, Goodacre S, Moyes C, Crawforth J, Sparey TJ, Patel S, Marwood R, Patel S, Thomas S, Hitzel L, O'Connor D, Szeto N, Castro JL, Hutson PH, MacLeod AM.
    J Med Chem; 2001 May 10; 44(10):1603-14. PubMed ID: 11334570
    [Abstract] [Full Text] [Related]

  • 68. 1-Sulfonyl-6-Piperazinyl-7-Azaindoles as potent and pseudo-selective 5-HT6 receptor antagonists.
    Fabritius CH, Pesonen U, Messinger J, Horvath R, Salo H, Gałęzowski M, Galek M, Stefańska K, Szeremeta-Spisak J, Olszak-Płachta M, Buda A, Adamczyk J, Król M, Prusis P, Sieprawska-Lupa M, Mikulski M, Kuokkanen K, Chapman H, Obuchowicz R, Korjamo T, Jalava N, Nowak M.
    Bioorg Med Chem Lett; 2016 Jun 01; 26(11):2610-5. PubMed ID: 27117428
    [Abstract] [Full Text] [Related]

  • 69. Synthesis and structure-activity relationships of new carbonyl guanidine derivatives as novel dual 5-HT₂B and 5-HT₇ receptor antagonists. Part 2.
    Moritomo A, Yamada H, Watanabe T, Itahana H, Koga Y, Akuzawa S, Okada M.
    Bioorg Med Chem; 2014 Aug 01; 22(15):4323-37. PubMed ID: 24916029
    [Abstract] [Full Text] [Related]

  • 70. Benzimidazolone-based serotonin 5-HT1A or 5-HT7R ligands: synthesis and biological evaluation.
    Badarau E, Suzenet F, Bojarski AJ, Fînaru AL, Guillaumet G.
    Bioorg Med Chem Lett; 2009 Mar 15; 19(6):1600-3. PubMed ID: 19237285
    [Abstract] [Full Text] [Related]

  • 71. N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-nitrophenyl) cyclohexanecarboxamide: a novel pre- and postsynaptic 5-hydroxytryptamine(1A) receptor antagonist active on the lower urinary tract.
    Leonardi A, Guarneri L, Poggesi E, Angelico P, Velasco C, Cilia A, Testa R.
    J Pharmacol Exp Ther; 2001 Dec 15; 299(3):1027-37. PubMed ID: 11714892
    [Abstract] [Full Text] [Related]

  • 72. Synthesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H(4) receptor antagonists.
    Terzioglu N, van Rijn RM, Bakker RA, De Esch IJ, Leurs R.
    Bioorg Med Chem Lett; 2004 Nov 01; 14(21):5251-6. PubMed ID: 15454206
    [Abstract] [Full Text] [Related]

  • 73. Optimization of the pharmacophore model for 5-HT7R antagonism. Design and synthesis of new naphtholactam and naphthosultam derivatives.
    López-Rodríguez ML, Porras E, Morcillo MJ, Benhamú B, Soto LJ, Lavandera JL, Ramos JA, Olivella M, Campillo M, Pardo L.
    J Med Chem; 2003 Dec 18; 46(26):5638-50. PubMed ID: 14667218
    [Abstract] [Full Text] [Related]

  • 74. Discovery of 7-arylsulfonyl-1,2,3,4, 4a,9a-hexahydro-benzo[4,5]furo[2,3-c]pyridines: identification of a potent and selective 5-HT₆ receptor antagonist showing activity in rat social recognition test.
    Tripathy R, McHugh RJ, Bacon ER, Salvino JM, Morton GC, Aimone LD, Huang Z, Mathiasen JR, DiCamillo A, Huffman MJ, McKenna BA, Kopec K, Lu LD, Qian J, Angeles TS, Connors T, Spais C, Holskin B, Duzic E, Schaffhauser H, Rossé GC.
    Bioorg Med Chem Lett; 2012 Feb 01; 22(3):1421-6. PubMed ID: 22226656
    [Abstract] [Full Text] [Related]

  • 75. Discovery of aryl-biphenyl-2-ylmethylpiperazines as novel scaffolds for 5-HT(7) ligands and role of the aromatic substituents in binding to the target receptor.
    Kim Y, Kim J, Tae J, Roth BL, Rhim H, Keum G, Nam G, Choo H.
    Bioorg Med Chem; 2013 May 01; 21(9):2568-76. PubMed ID: 23541835
    [Abstract] [Full Text] [Related]

  • 76. Novel arylsulfonamide derivatives with 5-HT₆/5-HT₇ receptor antagonism targeting behavioral and psychological symptoms of dementia.
    Kołaczkowski M, Marcinkowska M, Bucki A, Pawłowski M, Mitka K, Jaśkowska J, Kowalski P, Kazek G, Siwek A, Wasik A, Wesołowska A, Mierzejewski P, Bienkowski P.
    J Med Chem; 2014 Jun 12; 57(11):4543-57. PubMed ID: 24805037
    [Abstract] [Full Text] [Related]

  • 77. Novel 5-HT6 receptor antagonists/D2 receptor partial agonists targeting behavioral and psychological symptoms of dementia.
    Kołaczkowski M, Marcinkowska M, Bucki A, Śniecikowska J, Pawłowski M, Kazek G, Siwek A, Jastrzębska-Więsek M, Partyka A, Wasik A, Wesołowska A, Mierzejewski P, Bienkowski P.
    Eur J Med Chem; 2015 Mar 06; 92():221-35. PubMed ID: 25557493
    [Abstract] [Full Text] [Related]

  • 78. Dopamine/serotonin receptor ligands. Part IV [1]: synthesis and pharmacology of novel 3-benzazecines and 3-benzazonines as potential 5-HT2A and dopamine receptor ligands.
    El-Subbagh H, Wittig T, Decker M, Elz S, Nieger M, Lehmann J.
    Arch Pharm (Weinheim); 2002 Nov 06; 335(9):443-8. PubMed ID: 12447918
    [Abstract] [Full Text] [Related]

  • 79. 4-Aminoethylpiperazinyl aryl ketones with 5-HT₁A/5-HT₇ selectivity.
    Kim MK, Lee HS, Kim S, Cho SY, Roth BL, Chong Y, Choo H.
    Bioorg Med Chem; 2012 Jan 15; 20(2):1139-48. PubMed ID: 22196512
    [Abstract] [Full Text] [Related]

  • 80. Design, synthesis and preliminary screening of novel 3-(2-N,N-dimethylaminoethylthio) indole derivatives as potential 5-HT(6) receptor ligands.
    Kambhampati R, Konda J, Reballi V, Shinde AK, Dubey PK, Nirogi RV.
    J Enzyme Inhib Med Chem; 2008 Jun 15; 23(3):302-12. PubMed ID: 18569332
    [Abstract] [Full Text] [Related]

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