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305 related items for PubMed ID: 21135103

  • 1. Mechanistic insight into human ether-à-go-go-related gene (hERG) K+ channel deactivation gating from the solution structure of the EAG domain.
    Muskett FW, Thouta S, Thomson SJ, Bowen A, Stansfeld PJ, Mitcheson JS.
    J Biol Chem; 2011 Feb 25; 286(8):6184-91. PubMed ID: 21135103
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  • 3. A recombinant N-terminal domain fully restores deactivation gating in N-truncated and long QT syndrome mutant hERG potassium channels.
    Gustina AS, Trudeau MC.
    Proc Natl Acad Sci U S A; 2009 Aug 04; 106(31):13082-7. PubMed ID: 19651618
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  • 4. Two mutations at different positions in the CNBH domain of the hERG channel accelerate deactivation and impair the interaction with the EAG domain.
    Kume S, Shimomura T, Tateyama M, Kubo Y.
    J Physiol; 2018 Oct 04; 596(19):4629-4650. PubMed ID: 30086184
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  • 6. The N-terminal tail of hERG contains an amphipathic α-helix that regulates channel deactivation.
    Ng CA, Hunter MJ, Perry MD, Mobli M, Ke Y, Kuchel PW, King GF, Stock D, Vandenberg JI.
    PLoS One; 2011 Jan 13; 6(1):e16191. PubMed ID: 21249148
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  • 7. Voltage-dependent activation in EAG channels follows a ligand-receptor rather than a mechanical-lever mechanism.
    Malak OA, Gluhov GS, Grizel AV, Kudryashova KS, Sokolova OS, Loussouarn G.
    J Biol Chem; 2019 Apr 19; 294(16):6506-6521. PubMed ID: 30808709
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  • 8. hERG potassium channel gating is mediated by N- and C-terminal region interactions.
    Gustina AS, Trudeau MC.
    J Gen Physiol; 2011 Mar 19; 137(3):315-25. PubMed ID: 21357734
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  • 11. HERG potassium channel regulation by the N-terminal eag domain.
    Gustina AS, Trudeau MC.
    Cell Signal; 2012 Aug 19; 24(8):1592-8. PubMed ID: 22522181
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  • 12. Dynamic control of deactivation gating by a soluble amino-terminal domain in HERG K(+) channels.
    Wang J, Myers CD, Robertson GA.
    J Gen Physiol; 2000 Jun 19; 115(6):749-58. PubMed ID: 10828248
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  • 15. Multiple interactions between cytoplasmic domains regulate slow deactivation of Kv11.1 channels.
    Ng CA, Phan K, Hill AP, Vandenberg JI, Perry MD.
    J Biol Chem; 2014 Sep 12; 289(37):25822-32. PubMed ID: 25074935
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  • 18. Molecular determinants of interactions between the N-terminal domain and the transmembrane core that modulate hERG K+ channel gating.
    Fernández-Trillo J, Barros F, Machín A, Carretero L, Domínguez P, de la Peña P.
    PLoS One; 2011 Sep 12; 6(9):e24674. PubMed ID: 21935437
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  • 19. Regulation of deactivation by an amino terminal domain in human ether-à-go-go-related gene potassium channels.
    Wang J, Trudeau MC, Zappia AM, Robertson GA.
    J Gen Physiol; 1998 Nov 12; 112(5):637-47. PubMed ID: 9806971
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  • 20. Insight into the molecular interaction between the cyclic nucleotide-binding homology domain and the eag domain of the hERG channel.
    Li Q, Ng HQ, Yoon HS, Kang C.
    FEBS Lett; 2014 Aug 25; 588(17):2782-8. PubMed ID: 24931372
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