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Journal Abstract Search

811 related items for PubMed ID: 21143809

  • 1. Inhibition of the NEMO/IKKβ association complex formation, a novel mechanism associated with the NF-κB activation suppression by Withania somnifera's key metabolite withaferin A.
    Grover A, Shandilya A, Punetha A, Bisaria VS, Sundar D.
    BMC Genomics; 2010 Dec 02; 11 Suppl 4(Suppl 4):S25. PubMed ID: 21143809
    [Abstract] [Full Text] [Related]

  • 2. Hsp90/Cdc37 chaperone/co-chaperone complex, a novel junction anticancer target elucidated by the mode of action of herbal drug Withaferin A.
    Grover A, Shandilya A, Agrawal V, Pratik P, Bhasme D, Bisaria VS, Sundar D.
    BMC Bioinformatics; 2011 Feb 15; 12 Suppl 1(Suppl 1):S30. PubMed ID: 21342561
    [Abstract] [Full Text] [Related]

  • 3. Probing the anticancer mechanism of prospective herbal drug Withaferin A on mammals: a case study on human and bovine proteasomes.
    Grover A, Shandilya A, Bisaria VS, Sundar D.
    BMC Genomics; 2010 Dec 02; 11 Suppl 4(Suppl 4):S15. PubMed ID: 21143798
    [Abstract] [Full Text] [Related]

  • 4. Withaferin A inhibits NF-kappaB activation by targeting cysteine 179 in IKKβ.
    Heyninck K, Lahtela-Kakkonen M, Van der Veken P, Haegeman G, Vanden Berghe W.
    Biochem Pharmacol; 2014 Oct 15; 91(4):501-9. PubMed ID: 25159986
    [Abstract] [Full Text] [Related]

  • 5. Novel non-peptide small molecules preventing IKKβ/NEMO association inhibit NF-κB activation in LPS-stimulated J774 macrophages.
    De Falco F, Di Giovanni C, Cerchia C, De Stefano D, Capuozzo A, Irace C, Iuvone T, Santamaria R, Carnuccio R, Lavecchia A.
    Biochem Pharmacol; 2016 Mar 15; 104():83-94. PubMed ID: 26776306
    [Abstract] [Full Text] [Related]

  • 6. Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suppression of nuclear factor-kappaB (NF-kappaB) activation and NF-kappaB-regulated gene expression.
    Ichikawa H, Takada Y, Shishodia S, Jayaprakasam B, Nair MG, Aggarwal BB.
    Mol Cancer Ther; 2006 Jun 15; 5(6):1434-45. PubMed ID: 16818501
    [Abstract] [Full Text] [Related]

  • 7. Withaferin A disrupts ubiquitin-based NEMO reorganization induced by canonical NF-κB signaling.
    Jackson SS, Oberley C, Hooper CP, Grindle K, Wuerzberger-Davis S, Wolff J, McCool K, Rui L, Miyamoto S.
    Exp Cell Res; 2015 Feb 01; 331(1):58-72. PubMed ID: 25304104
    [Abstract] [Full Text] [Related]

  • 8. Thiol dependent NF-κB suppression and inhibition of T-cell mediated adaptive immune responses by a naturally occurring steroidal lactone Withaferin A.
    Gambhir L, Checker R, Sharma D, Thoh M, Patil A, Degani M, Gota V, Sandur SK.
    Toxicol Appl Pharmacol; 2015 Dec 01; 289(2):297-312. PubMed ID: 26408225
    [Abstract] [Full Text] [Related]

  • 9. Phosphorylation of serine 68 in the IkappaB kinase (IKK)-binding domain of NEMO interferes with the structure of the IKK complex and tumor necrosis factor-alpha-induced NF-kappaB activity.
    Palkowitsch L, Leidner J, Ghosh S, Marienfeld RB.
    J Biol Chem; 2008 Jan 04; 283(1):76-86. PubMed ID: 17977820
    [Abstract] [Full Text] [Related]

  • 10. NEMO-binding domains of both IKKalpha and IKKbeta regulate IkappaB kinase complex assembly and classical NF-kappaB activation.
    Solt LA, Madge LA, May MJ.
    J Biol Chem; 2009 Oct 02; 284(40):27596-608. PubMed ID: 19666475
    [Abstract] [Full Text] [Related]

  • 11. Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity.
    Kaileh M, Vanden Berghe W, Heyerick A, Horion J, Piette J, Libert C, De Keukeleire D, Essawi T, Haegeman G.
    J Biol Chem; 2007 Feb 16; 282(7):4253-4264. PubMed ID: 17150968
    [Abstract] [Full Text] [Related]

  • 12. Interleukin-1-induced NF-kappaB activation is NEMO-dependent but does not require IKKbeta.
    Solt LA, Madge LA, Orange JS, May MJ.
    J Biol Chem; 2007 Mar 23; 282(12):8724-33. PubMed ID: 17244613
    [Abstract] [Full Text] [Related]

  • 13. Regulation and function of IKK and IKK-related kinases.
    Häcker H, Karin M.
    Sci STKE; 2006 Oct 17; 2006(357):re13. PubMed ID: 17047224
    [Abstract] [Full Text] [Related]

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  • 16. Exogenous signal-independent nuclear IkappaB kinase activation triggered by Nkx3.2 enables constitutive nuclear degradation of IkappaB-alpha in chondrocytes.
    Yong Y, Choi SW, Choi HJ, Nam HW, Kim JA, Jeong DU, Kim DY, Kim YS, Kim DW.
    Mol Cell Biol; 2011 Jul 17; 31(14):2802-16. PubMed ID: 21606193
    [Abstract] [Full Text] [Related]

  • 17. Trichothecin induces cell death in NF-κB constitutively activated human cancer cells via inhibition of IKKβ phosphorylation.
    Su J, Zhao P, Kong L, Li X, Yan J, Zeng Y, Li Y.
    PLoS One; 2013 Jul 17; 8(8):e71333. PubMed ID: 23936501
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  • 19. Anti-cancer activity of withaferin A in B-cell lymphoma.
    McKenna MK, Gachuki BW, Alhakeem SS, Oben KN, Rangnekar VM, Gupta RC, Bondada S.
    Cancer Biol Ther; 2015 Jul 17; 16(7):1088-98. PubMed ID: 26020511
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