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130 related items for PubMed ID: 21144749

  • 1. Preparation, in vitro screening and molecular modelling of symmetrical 4-tert-butylpyridinium cholinesterase inhibitors--analogues of SAD-128.
    Musilek K, Roder J, Komloova M, Holas O, Hrabinova M, Pohanka M, Dohnal V, Opletalova V, Kuca K, Jung YS.
    Bioorg Med Chem Lett; 2011 Jan 01; 21(1):150-4. PubMed ID: 21144749
    [Abstract] [Full Text] [Related]

  • 2. Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage-initial study for Myasthenia gravis implications.
    Musilek K, Komloova M, Zavadova V, Holas O, Hrabinova M, Pohanka M, Dohnal V, Nachon F, Dolezal M, Kuca K, Jung YS.
    Bioorg Med Chem Lett; 2010 Mar 01; 20(5):1763-6. PubMed ID: 20138518
    [Abstract] [Full Text] [Related]

  • 3. The preparation, in vitro screening and molecular docking of symmetrical bisquaternary cholinesterase inhibitors containing a but-(2E)-en-1,4-diyl connecting linkage.
    Musilek K, Pavlikova R, Marek J, Komloova M, Holas O, Hrabinova M, Pohanka M, Dohnal V, Dolezal M, Gunn-Moore F, Kuca K.
    J Enzyme Inhib Med Chem; 2011 Apr 01; 26(2):245-53. PubMed ID: 21406034
    [Abstract] [Full Text] [Related]

  • 4. Preparation and in vitro screening of symmetrical bis-isoquinolinium cholinesterase inhibitors bearing various connecting linkage--implications for early Myasthenia gravis treatment.
    Musilek K, Komloova M, Holas O, Hrabinova M, Pohanka M, Dohnal V, Nachon F, Dolezal M, Kuca K.
    Eur J Med Chem; 2011 Feb 01; 46(2):811-8. PubMed ID: 21236521
    [Abstract] [Full Text] [Related]

  • 5. Kinetic analysis of interactions of different sarin and tabun analogues with human acetylcholinesterase and oximes: is there a structure-activity relationship?
    Aurbek N, Herkert NM, Koller M, Thiermann H, Worek F.
    Chem Biol Interact; 2010 Sep 06; 187(1-3):215-9. PubMed ID: 20105433
    [Abstract] [Full Text] [Related]

  • 6. Preparation, in vitro evaluation and molecular modelling of pyridinium-quinolinium/isoquinolinium non-symmetrical bisquaternary cholinesterase inhibitors.
    Komloova M, Horova A, Hrabinova M, Jun D, Dolezal M, Vinsova J, Kuca K, Musilek K.
    Bioorg Med Chem Lett; 2013 Dec 15; 23(24):6663-6. PubMed ID: 24220173
    [Abstract] [Full Text] [Related]

  • 7. Mono-oxime bisquaternary acetylcholinesterase reactivators with prop-1,3-diyl linkage-Preparation, in vitro screening and molecular docking.
    Musilek K, Komloova M, Holas O, Horova A, Pohanka M, Gunn-Moore F, Dohnal V, Dolezal M, Kuca K.
    Bioorg Med Chem; 2011 Jan 15; 19(2):754-62. PubMed ID: 21215642
    [Abstract] [Full Text] [Related]

  • 8. Synthesis of asymmetrical bispyridinium compounds bearing cyano-moiety and evaluation of their reactivation activity against tabun and paraoxon-inhibited acetylcholinesterase.
    Musilek K, Holas O, Kuca K, Jun D, Dohnal V, Dolezal M.
    Bioorg Med Chem Lett; 2006 Nov 01; 16(21):5673-6. PubMed ID: 16934462
    [Abstract] [Full Text] [Related]

  • 9. Monoquaternary pyridinium salts with modified side chain-synthesis and evaluation on model of tabun- and paraoxon-inhibited acetylcholinesterase.
    Musilek K, Kucera J, Jun D, Dohnal V, Opletalova V, Kuca K.
    Bioorg Med Chem; 2008 Sep 01; 16(17):8218-23. PubMed ID: 18676153
    [Abstract] [Full Text] [Related]

  • 10. Crystal structures of acetylcholinesterase in complex with HI-6, Ortho-7 and obidoxime: structural basis for differences in the ability to reactivate tabun conjugates.
    Ekström F, Pang YP, Boman M, Artursson E, Akfur C, Börjegren S.
    Biochem Pharmacol; 2006 Aug 28; 72(5):597-607. PubMed ID: 16876764
    [Abstract] [Full Text] [Related]

  • 11. Synthesis and biological evaluation of a new series of berberine derivatives as dual inhibitors of acetylcholinesterase and butyrylcholinesterase.
    Huang L, Luo Z, He F, Lu J, Li X.
    Bioorg Med Chem; 2010 Jun 15; 18(12):4475-84. PubMed ID: 20471843
    [Abstract] [Full Text] [Related]

  • 12. Synthesis, biological activity, and docking studies of new acetylcholinesterase inhibitors of the bispyridinium type.
    Kapková P, Stiefl N, Sürig U, Engels B, Baumann K, Holzgrabe U.
    Arch Pharm (Weinheim); 2003 Nov 15; 336(11):523-40. PubMed ID: 14639745
    [Abstract] [Full Text] [Related]

  • 13. Structure-activity relationships and binding mode in the human acetylcholinesterase active site of pseudo-irreversible inhibitors related to xanthostigmine.
    Rizzo S, Cavalli A, Ceccarini L, Bartolini M, Belluti F, Bisi A, Andrisano V, Recanatini M, Rampa A.
    ChemMedChem; 2009 Apr 15; 4(4):670-9. PubMed ID: 19222043
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  • 16. Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors--implications for early myasthenia gravis treatment.
    Komloova M, Musilek K, Horova A, Holas O, Dohnal V, Gunn-Moore F, Kuca K.
    Bioorg Med Chem Lett; 2011 Apr 15; 21(8):2505-9. PubMed ID: 21397501
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  • 19. Extensive SAR and computational studies of 3-{4-[(benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) derivatives.
    Piazzi L, Cavalli A, Belluti F, Bisi A, Gobbi S, Rizzo S, Bartolini M, Andrisano V, Recanatini M, Rampa A.
    J Med Chem; 2007 Aug 23; 50(17):4250-4. PubMed ID: 17655212
    [Abstract] [Full Text] [Related]

  • 20. Affinities of bispyridinium non-oxime compounds to [(3)H]epibatidine binding sites of Torpedo californica nicotinic acetylcholine receptors depend on linker length.
    Niessen KV, Seeger T, Tattersall JE, Timperley CM, Bird M, Green C, Thiermann H, Worek F.
    Chem Biol Interact; 2013 Dec 05; 206(3):545-54. PubMed ID: 24157926
    [Abstract] [Full Text] [Related]

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