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Journal Abstract Search

129 related items for PubMed ID: 21145880

  • 1. Evaluation of in vitro PXR-based assays and in silico modeling approaches for understanding the binding of a structurally diverse set of drugs to PXR.
    Xiao L, Nickbarg E, Wang W, Thomas A, Ziebell M, Prosise WW, Lesburg CA, Taremi SS, Gerlach VL, Le HV, Cheng KC.
    Biochem Pharmacol; 2011 Mar 01; 81(5):669-79. PubMed ID: 21145880
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  • 2. Structural insights into the promiscuity and function of the human pregnane X receptor.
    Watkins RE, Noble SM, Redinbo MR.
    Curr Opin Drug Discov Devel; 2002 Jan 01; 5(1):150-8. PubMed ID: 11865669
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  • 3. Correlation of high-throughput pregnane X receptor (PXR) transactivation and binding assays.
    Zhu Z, Kim S, Chen T, Lin JH, Bell A, Bryson J, Dubaquie Y, Yan N, Yanchunas J, Xie D, Stoffel R, Sinz M, Dickinson K.
    J Biomol Screen; 2004 Sep 01; 9(6):533-40. PubMed ID: 15452340
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  • 5. The identification of ligand features essential for PXR activation by pharmacophore modeling.
    Schuster D, Langer T.
    J Chem Inf Model; 2005 Sep 01; 45(2):431-9. PubMed ID: 15807509
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  • 7. Development of in silico filters to predict activation of the pregnane X receptor (PXR) by structurally diverse drug-like molecules.
    Matter H, Anger LT, Giegerich C, Güssregen S, Hessler G, Baringhaus KH.
    Bioorg Med Chem; 2012 Sep 15; 20(18):5352-65. PubMed ID: 22560839
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  • 9. Human pregnane X receptor antagonists and agonists define molecular requirements for different binding sites.
    Ekins S, Chang C, Mani S, Krasowski MD, Reschly EJ, Iyer M, Kholodovych V, Ai N, Welsh WJ, Sinz M, Swaan PW, Patel R, Bachmann K.
    Mol Pharmacol; 2007 Sep 15; 72(3):592-603. PubMed ID: 17576789
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  • 13. The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity.
    Watkins RE, Wisely GB, Moore LB, Collins JL, Lambert MH, Williams SP, Willson TM, Kliewer SA, Redinbo MR.
    Science; 2001 Jun 22; 292(5525):2329-33. PubMed ID: 11408620
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  • 15. Repression of PXR-mediated induction of hepatic CYP3A gene expression by protein kinase C.
    Ding X, Staudinger JL.
    Biochem Pharmacol; 2005 Mar 01; 69(5):867-73. PubMed ID: 15710363
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  • 16. Activation of a tunicate (Ciona intestinalis) xenobiotic receptor orthologue by both natural toxins and synthetic toxicants.
    Fidler AE, Holland PT, Reschly EJ, Ekins S, Krasowski MD.
    Toxicon; 2012 Feb 01; 59(2):365-72. PubMed ID: 22206814
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  • 17. Structural model reveals key interactions in the assembly of the pregnane X receptor/corepressor complex.
    Wang CY, Li CW, Chen JD, Welsh WJ.
    Mol Pharmacol; 2006 May 01; 69(5):1513-7. PubMed ID: 16452398
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  • 18. Expression and transcriptional activities of nuclear receptors involved in regulation of drug-metabolizing enzymes are not altered by colchicine: focus on PXR, CAR, and GR in primary human hepatocytes.
    Dvorák Z, Maurel P, Vilarem MJ, Ulrichová J, Modrianský M.
    Cell Biol Toxicol; 2007 Mar 01; 23(2):63-73. PubMed ID: 16964586
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  • 19. QSAR model for human pregnane X receptor (PXR) binding: screening of environmental chemicals and correlations with genotoxicity, endocrine disruption and teratogenicity.
    Dybdahl M, Nikolov NG, Wedebye EB, Jónsdóttir SÓ, Niemelä JR.
    Toxicol Appl Pharmacol; 2012 Aug 01; 262(3):301-9. PubMed ID: 22627063
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