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Journal Abstract Search

244 related items for PubMed ID: 21147780

  • 1. In vivo evidence that furin from hepatocytes inactivates PCSK9.
    Essalmani R, Susan-Resiga D, Chamberland A, Abifadel M, Creemers JW, Boileau C, Seidah NG, Prat A.
    J Biol Chem; 2011 Feb 11; 286(6):4257-63. PubMed ID: 21147780
    [Abstract] [Full Text] [Related]

  • 2. Thrombin activation of protein C requires prior processing by a liver proprotein convertase.
    Essalmani R, Susan-Resiga D, Guillemot J, Kim W, Sachan V, Awan Z, Chamberland A, Asselin MC, Ly K, Desjardins R, Day R, Prat A, Seidah NG.
    J Biol Chem; 2017 Jun 23; 292(25):10564-10573. PubMed ID: 28468828
    [Abstract] [Full Text] [Related]

  • 3. Dual mechanisms for the fibrate-mediated repression of proprotein convertase subtilisin/kexin type 9.
    Kourimate S, Le May C, Langhi C, Jarnoux AL, Ouguerram K, Zaïr Y, Nguyen P, Krempf M, Cariou B, Costet P.
    J Biol Chem; 2008 Apr 11; 283(15):9666-73. PubMed ID: 18245819
    [Abstract] [Full Text] [Related]

  • 4. Furin-cleaved proprotein convertase subtilisin/kexin type 9 (PCSK9) is active and modulates low density lipoprotein receptor and serum cholesterol levels.
    Lipari MT, Li W, Moran P, Kong-Beltran M, Sai T, Lai J, Lin SJ, Kolumam G, Zavala-Solorio J, Izrael-Tomasevic A, Arnott D, Wang J, Peterson AS, Kirchhofer D.
    J Biol Chem; 2012 Dec 21; 287(52):43482-91. PubMed ID: 23135270
    [Abstract] [Full Text] [Related]

  • 5. The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications.
    Benjannet S, Rhainds D, Hamelin J, Nassoury N, Seidah NG.
    J Biol Chem; 2006 Oct 13; 281(41):30561-72. PubMed ID: 16912035
    [Abstract] [Full Text] [Related]

  • 6. Asialoglycoprotein receptor 1 is a novel PCSK9-independent ligand of liver LDLR cleaved by furin.
    Susan-Resiga D, Girard E, Essalmani R, Roubtsova A, Marcinkiewicz J, Derbali RM, Evagelidis A, Byun JH, Lebeau PF, Austin RC, Seidah NG.
    J Biol Chem; 2021 Oct 13; 297(4):101177. PubMed ID: 34508778
    [Abstract] [Full Text] [Related]

  • 7. Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes.
    Essalmani R, Susan-Resiga D, Chamberland A, Asselin MC, Canuel M, Constam D, Creemers JW, Day R, Gauthier D, Prat A, Seidah NG.
    J Biol Chem; 2013 Sep 13; 288(37):26410-8. PubMed ID: 23918928
    [Abstract] [Full Text] [Related]

  • 8. Proprotein convertase subtilisin/kexin type 9 (PCSK9): hepatocyte-specific low-density lipoprotein receptor degradation and critical role in mouse liver regeneration.
    Zaid A, Roubtsova A, Essalmani R, Marcinkiewicz J, Chamberland A, Hamelin J, Tremblay M, Jacques H, Jin W, Davignon J, Seidah NG, Prat A.
    Hepatology; 2008 Aug 13; 48(2):646-54. PubMed ID: 18666258
    [Abstract] [Full Text] [Related]

  • 9. The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2.
    Poirier S, Mayer G, Benjannet S, Bergeron E, Marcinkiewicz J, Nassoury N, Mayer H, Nimpf J, Prat A, Seidah NG.
    J Biol Chem; 2008 Jan 25; 283(4):2363-72. PubMed ID: 18039658
    [Abstract] [Full Text] [Related]

  • 10. Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice.
    Lagace TA, Curtis DE, Garuti R, McNutt MC, Park SW, Prather HB, Anderson NN, Ho YK, Hammer RE, Horton JD.
    J Clin Invest; 2006 Nov 25; 116(11):2995-3005. PubMed ID: 17080197
    [Abstract] [Full Text] [Related]

  • 11. NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol.
    Benjannet S, Rhainds D, Essalmani R, Mayne J, Wickham L, Jin W, Asselin MC, Hamelin J, Varret M, Allard D, Trillard M, Abifadel M, Tebon A, Attie AD, Rader DJ, Boileau C, Brissette L, Chrétien M, Prat A, Seidah NG.
    J Biol Chem; 2004 Nov 19; 279(47):48865-75. PubMed ID: 15358785
    [Abstract] [Full Text] [Related]

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  • 13. Implication of the proprotein convertase NARC-1/PCSK9 in the development of the nervous system.
    Poirier S, Prat A, Marcinkiewicz E, Paquin J, Chitramuthu BP, Baranowski D, Cadieux B, Bennett HP, Seidah NG.
    J Neurochem; 2006 Aug 19; 98(3):838-50. PubMed ID: 16893422
    [Abstract] [Full Text] [Related]

  • 14. Function and distribution of circulating human PCSK9 expressed extrahepatically in transgenic mice.
    Luo Y, Warren L, Xia D, Jensen H, Sand T, Petras S, Qin W, Miller KS, Hawkins J.
    J Lipid Res; 2009 Aug 19; 50(8):1581-8. PubMed ID: 19060325
    [Abstract] [Full Text] [Related]

  • 15. Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9.
    Rashid S, Curtis DE, Garuti R, Anderson NN, Bashmakov Y, Ho YK, Hammer RE, Moon YA, Horton JD.
    Proc Natl Acad Sci U S A; 2005 Apr 12; 102(15):5374-9. PubMed ID: 15805190
    [Abstract] [Full Text] [Related]

  • 16. The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR.
    Nassoury N, Blasiole DA, Tebon Oler A, Benjannet S, Hamelin J, Poupon V, McPherson PS, Attie AD, Prat A, Seidah NG.
    Traffic; 2007 Jun 12; 8(6):718-32. PubMed ID: 17461796
    [Abstract] [Full Text] [Related]

  • 17. Inhibition of PCSK9 as a novel strategy for the treatment of hypercholesterolemia.
    Lopez D.
    Drug News Perspect; 2008 Jun 12; 21(6):323-30. PubMed ID: 18836590
    [Abstract] [Full Text] [Related]

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  • 19. The unique role of proprotein convertase subtilisin/kexin 9 in cholesterol homeostasis.
    Mousavi SA, Berge KE, Leren TP.
    J Intern Med; 2009 Dec 12; 266(6):507-19. PubMed ID: 19930098
    [Abstract] [Full Text] [Related]

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