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247 related items for PubMed ID: 21177334

  • 1. Heat shock protein 90 maintains the tumour-like character of rheumatoid synovial cells by stabilizing integrin-linked kinase, extracellular signal-regulated kinase and protein kinase B.
    Hashiramoto A, Murata M, Kawazoe T, Yoshida K, Akiyama C, Shiozawa K, Shiozawa S.
    Rheumatology (Oxford); 2011 May; 50(5):852-61. PubMed ID: 21177334
    [Abstract] [Full Text] [Related]

  • 2. Inhibition of heat shock protein 90 function by 17-allylamino-17-demethoxy-geldanamycin in Hodgkin's lymphoma cells down-regulates Akt kinase, dephosphorylates extracellular signal-regulated kinase, and induces cell cycle arrest and cell death.
    Georgakis GV, Li Y, Rassidakis GZ, Martinez-Valdez H, Medeiros LJ, Younes A.
    Clin Cancer Res; 2006 Jan 15; 12(2):584-90. PubMed ID: 16428504
    [Abstract] [Full Text] [Related]

  • 3. Angiopoietin 1 directly induces destruction of the rheumatoid joint by cooperative, but independent, signaling via ERK/MAPK and phosphatidylinositol 3-kinase/Akt.
    Hashiramoto A, Sakai C, Yoshida K, Tsumiyama K, Miura Y, Shiozawa K, Nose M, Komai K, Shiozawa S.
    Arthritis Rheum; 2007 Jul 15; 56(7):2170-9. PubMed ID: 17599743
    [Abstract] [Full Text] [Related]

  • 4. Heat shock protein 90 inhibitor induces apoptosis and attenuates activation of hepatic stellate cells.
    Myung SJ, Yoon JH, Kim BH, Lee JH, Jung EU, Lee HS.
    J Pharmacol Exp Ther; 2009 Jul 15; 330(1):276-82. PubMed ID: 19329756
    [Abstract] [Full Text] [Related]

  • 5. Anti-apoptotic effect of heat shock protein 90 on hypoxia-mediated cardiomyocyte damage is mediated via the phosphatidylinositol 3-kinase/AKT pathway.
    Wang W, Peng Y, Wang Y, Zhao X, Yuan Z.
    Clin Exp Pharmacol Physiol; 2009 Sep 15; 36(9):899-903. PubMed ID: 19298537
    [Abstract] [Full Text] [Related]

  • 6. Heat shock protein 90 (Hsp90) regulates the stability of transforming growth factor beta-activated kinase 1 (TAK1) in interleukin-1beta-induced cell signaling.
    Shi L, Zhang Z, Fang S, Xu J, Liu J, Shen J, Fang F, Luo L, Yin Z.
    Mol Immunol; 2009 Feb 15; 46(4):541-50. PubMed ID: 18950863
    [Abstract] [Full Text] [Related]

  • 7. The heat-shock protein 90 inhibitor, geldanamycin, induces apoptotic cell death in Epstein-Barr virus-positive NK/T-cell lymphoma by Akt down-regulation.
    Jeon YK, Park CH, Kim KY, Li YC, Kim J, Kim YA, Paik JH, Park BK, Kim CW, Kim YN.
    J Pathol; 2007 Oct 15; 213(2):170-9. PubMed ID: 17768706
    [Abstract] [Full Text] [Related]

  • 8. Geldanamycin inhibits tyrosine phosphorylation-dependent NF-kappaB activation.
    Crèvecoeur J, Merville MP, Piette J, Gloire G.
    Biochem Pharmacol; 2008 Jun 01; 75(11):2183-91. PubMed ID: 18455150
    [Abstract] [Full Text] [Related]

  • 9. Necessary role of phosphatidylinositol 3-kinase in transforming growth factor beta-mediated activation of Akt in normal and rheumatoid arthritis synovial fibroblasts.
    Kim G, Jun JB, Elkon KB.
    Arthritis Rheum; 2002 Jun 01; 46(6):1504-11. PubMed ID: 12115180
    [Abstract] [Full Text] [Related]

  • 10. Regulation of tumor necrosis factor alpha-mediated apoptosis of rheumatoid arthritis synovial fibroblasts by the protein kinase Akt.
    Zhang HG, Wang Y, Xie JF, Liang X, Liu D, Yang P, Hsu HC, Ray RB, Mountz JD.
    Arthritis Rheum; 2001 Jul 01; 44(7):1555-67. PubMed ID: 11465707
    [Abstract] [Full Text] [Related]

  • 11. Anti-malarial agent artesunate inhibits TNF-alpha-induced production of proinflammatory cytokines via inhibition of NF-kappaB and PI3 kinase/Akt signal pathway in human rheumatoid arthritis fibroblast-like synoviocytes.
    Xu H, He Y, Yang X, Liang L, Zhan Z, Ye Y, Yang X, Lian F, Sun L.
    Rheumatology (Oxford); 2007 Jun 01; 46(6):920-6. PubMed ID: 17314215
    [Abstract] [Full Text] [Related]

  • 12. IL-17 induces production of IL-6 and IL-8 in rheumatoid arthritis synovial fibroblasts via NF-kappaB- and PI3-kinase/Akt-dependent pathways.
    Hwang SY, Kim JY, Kim KW, Park MK, Moon Y, Kim WU, Kim HY.
    Arthritis Res Ther; 2004 Jun 01; 6(2):R120-8. PubMed ID: 15059275
    [Abstract] [Full Text] [Related]

  • 13. Geldanamycin, an inhibitor of Hsp90, sensitizes human tumour cells to radiation.
    Machida H, Matsumoto Y, Shirai M, Kubota N.
    Int J Radiat Biol; 2003 Dec 01; 79(12):973-80. PubMed ID: 14713575
    [Abstract] [Full Text] [Related]

  • 14. [Study on signal transduction pathway in differentiation and apoptosis of leukemia cells induced by heat shock protein inhibitor].
    Yu WJ, Rao Q, Wang M, Tian Z, Xu ZF, Wang JX.
    Zhonghua Xue Ye Xue Za Zhi; 2007 Oct 01; 28(10):677-80. PubMed ID: 18399173
    [Abstract] [Full Text] [Related]

  • 15. NF-kappaB-regulated expression of cellular FLIP protects rheumatoid arthritis synovial fibroblasts from tumor necrosis factor alpha-mediated apoptosis.
    Bai S, Liu H, Chen KH, Eksarko P, Perlman H, Moore TL, Pope RM.
    Arthritis Rheum; 2004 Dec 01; 50(12):3844-55. PubMed ID: 15593196
    [Abstract] [Full Text] [Related]

  • 16. Geldanamycin interferes with the 90-kDa heat shock protein, affecting lipopolysaccharide-mediated interleukin-1 expression and apoptosis within macrophages.
    Hsu HY, Wu HL, Tan SK, Li VP, Wang WT, Hsu J, Cheng CH.
    Mol Pharmacol; 2007 Jan 01; 71(1):344-56. PubMed ID: 16868182
    [Abstract] [Full Text] [Related]

  • 17. Proteome-wide changes induced by the Hsp90 inhibitor, geldanamycin in anaplastic large cell lymphoma cells.
    Schumacher JA, Crockett DK, Elenitoba-Johnson KS, Lim MS.
    Proteomics; 2007 Aug 01; 7(15):2603-16. PubMed ID: 17610208
    [Abstract] [Full Text] [Related]

  • 18. Amplification of the synovial inflammatory response through activation of mitogen-activated protein kinases and nuclear factor kappaB using ligation of CD40 on CD14+ synovial cells from patients with rheumatoid arthritis.
    Harigai M, Hara M, Kawamoto M, Kawaguchi Y, Sugiura T, Tanaka M, Nakagawa M, Ichida H, Takagi K, Higami-Ohsako S, Shimada K, Kamatani N.
    Arthritis Rheum; 2004 Jul 01; 50(7):2167-77. PubMed ID: 15248214
    [Abstract] [Full Text] [Related]

  • 19. [Heat shock activated Rac-MEKK-JNK pathway and hsp90 beta gene expression].
    Li XY, Lu C, Wu NH, Shen YF.
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 2002 Jun 01; 24(3):264-8. PubMed ID: 12905631
    [Abstract] [Full Text] [Related]

  • 20. Genetic deletion of PKR abrogates TNF-induced activation of IkappaBalpha kinase, JNK, Akt and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activation.
    Takada Y, Ichikawa H, Pataer A, Swisher S, Aggarwal BB.
    Oncogene; 2007 Feb 22; 26(8):1201-12. PubMed ID: 16924232
    [Abstract] [Full Text] [Related]

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