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Journal Abstract Search

275 related items for PubMed ID: 21189350

  • 1. Novel bacterial NAD+-dependent DNA ligase inhibitors with broad-spectrum activity and antibacterial efficacy in vivo.
    Mills SD, Eakin AE, Buurman ET, Newman JV, Gao N, Huynh H, Johnson KD, Lahiri S, Shapiro AB, Walkup GK, Yang W, Stokes SS.
    Antimicrob Agents Chemother; 2011 Mar; 55(3):1088-96. PubMed ID: 21189350
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  • 2. Mechanistic assessment of DNA ligase as an antibacterial target in Staphylococcus aureus.
    Podos SD, Thanassi JA, Pucci MJ.
    Antimicrob Agents Chemother; 2012 Aug; 56(8):4095-102. PubMed ID: 22585221
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  • 3. Identification and characterization of an inhibitor specific to bacterial NAD+-dependent DNA ligases.
    Meier TI, Yan D, Peery RB, McAllister KA, Zook C, Peng SB, Zhao G.
    FEBS J; 2008 Nov; 275(21):5258-71. PubMed ID: 18795946
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  • 4. Discovery of bacterial NAD+-dependent DNA ligase inhibitors: optimization of antibacterial activity.
    Stokes SS, Huynh H, Gowravaram M, Albert R, Cavero-Tomas M, Chen B, Harang J, Loch JT, Lu M, Mullen GB, Zhao S, Liu CF, Mills SD.
    Bioorg Med Chem Lett; 2011 Aug 01; 21(15):4556-60. PubMed ID: 21719282
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  • 10. New class of bacterial phenylalanyl-tRNA synthetase inhibitors with high potency and broad-spectrum activity.
    Beyer D, Kroll HP, Endermann R, Schiffer G, Siegel S, Bauser M, Pohlmann J, Brands M, Ziegelbauer K, Haebich D, Eymann C, Brötz-Oesterhelt H.
    Antimicrob Agents Chemother; 2004 Feb 01; 48(2):525-32. PubMed ID: 14742205
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  • 11. Structure based identification of first-in-class fragment inhibitors that target the NMN pocket of M. tuberculosis NAD+-dependent DNA ligase A.
    Shukla A, Afsar M, Kumar N, Kumar S, Ramachandran R.
    J Struct Biol; 2021 Mar 01; 213(1):107655. PubMed ID: 33197566
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  • 12. Identification through structure-based methods of a bacterial NAD(+)-dependent DNA ligase inhibitor that avoids known resistance mutations.
    Murphy-Benenato K, Wang H, McGuire HM, Davis HE, Gao N, Prince DB, Jahic H, Stokes SS, Boriack-Sjodin PA.
    Bioorg Med Chem Lett; 2014 Jan 01; 24(1):360-6. PubMed ID: 24287382
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  • 13. Negishi cross-coupling enabled synthesis of novel NAD(+)-dependent DNA ligase inhibitors and SAR development.
    Murphy-Benenato KE, Gingipalli L, Boriack-Sjodin PA, Martinez-Botella G, Carcanague D, Eyermann CJ, Gowravaram M, Harang J, Hale MR, Ioannidis G, Jahic H, Johnstone M, Kutschke A, Laganas VA, Loch JT, Miller MD, Oguto H, Patel SJ.
    Bioorg Med Chem Lett; 2015 Nov 15; 25(22):5172-7. PubMed ID: 26463129
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  • 18. Pharmacokinetics/Pharmacodynamics of Peptide Deformylase Inhibitor GSK1322322 against Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus in Rodent Models of Infection.
    Hoover J, Lewandowski T, Straub RJ, Novick SJ, DeMarsh P, Aubart K, Rittenhouse S, Zalacain M.
    Antimicrob Agents Chemother; 2016 Jan 15; 60(1):180-9. PubMed ID: 26482300
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  • 19. The kinetic mechanism of S. pneumoniae DNA ligase and inhibition by adenosine-based antibacterial compounds.
    Jahić H, Liu CF, Thresher J, Livchak S, Wang H, Ehmann DE.
    Biochem Pharmacol; 2012 Sep 01; 84(5):654-60. PubMed ID: 22743594
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  • 20. Pharmacodynamics of a new cephalosporin, PPI-0903 (TAK-599), active against methicillin-resistant Staphylococcus aureus in murine thigh and lung infection models: identification of an in vivo pharmacokinetic-pharmacodynamic target.
    Andes D, Craig WA.
    Antimicrob Agents Chemother; 2006 Apr 01; 50(4):1376-83. PubMed ID: 16569855
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