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Journal Abstract Search

451 related items for PubMed ID: 21198544

  • 1. γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent.
    Rajendran P, Li F, Manu KA, Shanmugam MK, Loo SY, Kumar AP, Sethi G.
    Br J Pharmacol; 2011 May; 163(2):283-98. PubMed ID: 21198544
    [Abstract] [Full Text] [Related]

  • 2. γ-Tocotrienol but not γ-tocopherol blocks STAT3 cell signaling pathway through induction of protein-tyrosine phosphatase SHP-1 and sensitizes tumor cells to chemotherapeutic agents.
    Kannappan R, Yadav VR, Aggarwal BB.
    J Biol Chem; 2010 Oct 22; 285(43):33520-33529. PubMed ID: 20720018
    [Abstract] [Full Text] [Related]

  • 3. Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1.
    Rajendran P, Li F, Shanmugam MK, Vali S, Abbasi T, Kapoor S, Ahn KS, Kumar AP, Sethi G.
    J Cell Physiol; 2012 May 22; 227(5):2184-95. PubMed ID: 21792937
    [Abstract] [Full Text] [Related]

  • 4. Butein suppresses constitutive and inducible signal transducer and activator of transcription (STAT) 3 activation and STAT3-regulated gene products through the induction of a protein tyrosine phosphatase SHP-1.
    Pandey MK, Sung B, Ahn KS, Aggarwal BB.
    Mol Pharmacol; 2009 Mar 22; 75(3):525-33. PubMed ID: 19103760
    [Abstract] [Full Text] [Related]

  • 5. Identification of beta-escin as a novel inhibitor of signal transducer and activator of transcription 3/Janus-activated kinase 2 signaling pathway that suppresses proliferation and induces apoptosis in human hepatocellular carcinoma cells.
    Tan SM, Li F, Rajendran P, Kumar AP, Hui KM, Sethi G.
    J Pharmacol Exp Ther; 2010 Jul 22; 334(1):285-93. PubMed ID: 20378717
    [Abstract] [Full Text] [Related]

  • 6. Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation.
    Bhutani M, Pathak AK, Nair AS, Kunnumakkara AB, Guha S, Sethi G, Aggarwal BB.
    Clin Cancer Res; 2007 May 15; 13(10):3024-32. PubMed ID: 17505005
    [Abstract] [Full Text] [Related]

  • 7. Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3.
    Subramaniam A, Shanmugam MK, Ong TH, Li F, Perumal E, Chen L, Vali S, Abbasi T, Kapoor S, Ahn KS, Kumar AP, Hui KM, Sethi G.
    Br J Pharmacol; 2013 Oct 15; 170(4):807-21. PubMed ID: 23848338
    [Abstract] [Full Text] [Related]

  • 8. Thymoquinone inhibits proliferation, induces apoptosis and chemosensitizes human multiple myeloma cells through suppression of signal transducer and activator of transcription 3 activation pathway.
    Li F, Rajendran P, Sethi G.
    Br J Pharmacol; 2010 Oct 15; 161(3):541-54. PubMed ID: 20880395
    [Abstract] [Full Text] [Related]

  • 9. Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells.
    Li F, Fernandez PP, Rajendran P, Hui KM, Sethi G.
    Cancer Lett; 2010 Jun 28; 292(2):197-207. PubMed ID: 20053498
    [Abstract] [Full Text] [Related]

  • 10. Capillarisin inhibits constitutive and inducible STAT3 activation through induction of SHP-1 and SHP-2 tyrosine phosphatases.
    Lee JH, Chiang SY, Nam D, Chung WS, Lee J, Na YS, Sethi G, Ahn KS.
    Cancer Lett; 2014 Apr 01; 345(1):140-8. PubMed ID: 24333736
    [Abstract] [Full Text] [Related]

  • 11. Crocetin imparts antiproliferative activity via inhibiting STAT3 signaling in hepatocellular carcinoma.
    Mohan CD, Kim C, Siveen KS, Manu KA, Rangappa S, Chinnathambi A, Alharbi SA, Rangappa KS, Kumar AP, Ahn KS.
    IUBMB Life; 2021 Nov 01; 73(11):1348-1362. PubMed ID: 34514729
    [Abstract] [Full Text] [Related]

  • 12. 5-hydroxy-2-methyl-1,4-naphthoquinone, a vitamin K3 analogue, suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase, SHP-1: potential role in chemosensitization.
    Sandur SK, Pandey MK, Sung B, Aggarwal BB.
    Mol Cancer Res; 2010 Jan 01; 8(1):107-18. PubMed ID: 20068065
    [Abstract] [Full Text] [Related]

  • 13. β-Caryophyllene oxide inhibits constitutive and inducible STAT3 signaling pathway through induction of the SHP-1 protein tyrosine phosphatase.
    Kim C, Cho SK, Kapoor S, Kumar A, Vali S, Abbasi T, Kim SH, Sethi G, Ahn KS.
    Mol Carcinog; 2014 Oct 01; 53(10):793-806. PubMed ID: 23765383
    [Abstract] [Full Text] [Related]

  • 14. Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis.
    Ahn KS, Sethi G, Krishnan K, Aggarwal BB.
    J Biol Chem; 2007 Jan 05; 282(1):809-20. PubMed ID: 17114179
    [Abstract] [Full Text] [Related]

  • 15. First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathway.
    Manu KA, Shanmugam MK, Ramachandran L, Li F, Fong CW, Kumar AP, Tan P, Sethi G.
    Clin Cancer Res; 2012 Apr 15; 18(8):2220-9. PubMed ID: 22351692
    [Abstract] [Full Text] [Related]

  • 16. Dihydroxypentamethoxyflavone down-regulates constitutive and inducible signal transducers and activators of transcription-3 through the induction of tyrosine phosphatase SHP-1.
    Phromnoi K, Prasad S, Gupta SC, Kannappan R, Reuter S, Limtrakul P, Aggarwal BB.
    Mol Pharmacol; 2011 Nov 15; 80(5):889-99. PubMed ID: 21816954
    [Abstract] [Full Text] [Related]

  • 17. Y-tocotrienol inhibits angiogenesis-dependent growth of human hepatocellular carcinoma through abrogation of AKT/mTOR pathway in an orthotopic mouse model.
    Siveen KS, Ahn KS, Ong TH, Shanmugam MK, Li F, Yap WN, Kumar AP, Fong CW, Tergaonkar V, Hui KM, Sethi G.
    Oncotarget; 2014 Apr 15; 5(7):1897-911. PubMed ID: 24722367
    [Abstract] [Full Text] [Related]

  • 18. Negative regulation of signal transducer and activator of transcription-3 signalling cascade by lupeol inhibits growth and induces apoptosis in hepatocellular carcinoma cells.
    Siveen KS, Nguyen AH, Lee JH, Li F, Singh SS, Kumar AP, Low G, Jha S, Tergaonkar V, Ahn KS, Sethi G.
    Br J Cancer; 2014 Sep 23; 111(7):1327-37. PubMed ID: 25101566
    [Abstract] [Full Text] [Related]

  • 19. Evodiamine inhibits STAT3 signaling by inducing phosphatase shatterproof 1 in hepatocellular carcinoma cells.
    Yang J, Cai X, Lu W, Hu C, Xu X, Yu Q, Cao P.
    Cancer Lett; 2013 Jan 28; 328(2):243-51. PubMed ID: 23032719
    [Abstract] [Full Text] [Related]

  • 20. Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through induction of a protein tyrosine phosphatase SHP-1.
    Ahn KS, Sethi G, Sung B, Goel A, Ralhan R, Aggarwal BB.
    Cancer Res; 2008 Jun 01; 68(11):4406-15. PubMed ID: 18519703
    [Abstract] [Full Text] [Related]

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