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154 related items for PubMed ID: 2120440

  • 21. Synthesis and biological activity of some transition-state inhibitors of human renin.
    Bühlmayer P, Caselli A, Fuhrer W, Göschke R, Rasetti V, Rüeger H, Stanton JL, Criscione L, Wood JM.
    J Med Chem; 1988 Sep; 31(9):1839-46. PubMed ID: 3137345
    [Abstract] [Full Text] [Related]

  • 22. New inhibitors of human renin that contain novel Leu-Val replacements. Examination of the P1 site.
    Luly JR, Bolis G, BaMaung N, Soderquist J, Dellaria JF, Stein H, Cohen J, Perun TJ, Greer J, Plattner JJ.
    J Med Chem; 1988 Mar; 31(3):532-9. PubMed ID: 3279206
    [Abstract] [Full Text] [Related]

  • 23. Renin inhibitors. I. Synthesis and structure-activity relationships of transition-state inhibitors containing homostatine analogues at the scissile bond.
    Atsuumi S, Nakano M, Koike Y, Tanaka S, Matsuyama K, Nakano M, Morishima H.
    Chem Pharm Bull (Tokyo); 1992 Feb; 40(2):364-70. PubMed ID: 1606632
    [Abstract] [Full Text] [Related]

  • 24. Statine-containing dipeptide and tripeptide inhibitors of human renin.
    Kokubu T, Hiwada K, Nagae A, Murakami E, Morisawa Y, Yabe Y, Koike H, Iijima Y.
    Hypertension; 1986 Jun; 8(6 Pt 2):II1-5. PubMed ID: 3087874
    [Abstract] [Full Text] [Related]

  • 25. Design and synthesis of renin inhibitors: incorporation of transition-state isostere side chains that span from the S1 to the S3 binding pockets and examination of P3-modified renin inhibitors.
    Plummer MS, Shahripour A, Kaltenbronn JS, Lunney EA, Steinbaugh BA, Hamby JM, Hamilton HW, Sawyer TK, Humblet C, Doherty AM.
    J Med Chem; 1995 Jul 21; 38(15):2893-905. PubMed ID: 7636850
    [Abstract] [Full Text] [Related]

  • 26. New renin inhibitors containing novel analogues of statine.
    Jones DM, Sueiras-Diaz J, Szelke M, Leckie BJ, Beattie SR, Morton J, Neidle S, Kuroda R.
    J Pept Res; 1997 Aug 21; 50(2):109-21. PubMed ID: 9273895
    [Abstract] [Full Text] [Related]

  • 27. Inhibition of porcine pepsin by two substrate analogues containing statine. The effect of histidine at the P2 subsite on the inhibition of aspartic proteinases.
    Maibaum J, Rich DH.
    J Med Chem; 1988 Mar 21; 31(3):625-9. PubMed ID: 3126296
    [Abstract] [Full Text] [Related]

  • 28. Renin inhibitors. Dipeptide analogues of angiotensinogen utilizing a structurally modified phenylalanine residue to impart proteolytic stability.
    Plattner JJ, Marcotte PA, Kleinert HD, Stein HH, Greer J, Bolis G, Fung AK, Bopp BA, Luly JR, Sham HL.
    J Med Chem; 1988 Dec 21; 31(12):2277-88. PubMed ID: 3143010
    [Abstract] [Full Text] [Related]

  • 29. Renin inhibitors. Dipeptide analogues of angiotensinogen incorporating transition-state, nonpeptidic replacements at the scissile bond.
    Bolis G, Fung AK, Greer J, Kleinert HD, Marcotte PA, Perun TJ, Plattner JJ, Stein HH.
    J Med Chem; 1987 Oct 21; 30(10):1729-37. PubMed ID: 3309313
    [Abstract] [Full Text] [Related]

  • 30. Novel renin inhibitors containing a non-peptide aminoalkanoyl moiety at P1-P1' position.
    Winiecka I, Marszałek D, Goldnik A, Jaworski P, Mazurek AP.
    Pharmazie; 2014 Apr 21; 69(4):263-70. PubMed ID: 24791589
    [Abstract] [Full Text] [Related]

  • 31. KRI-1314: an orally effective inhibitor of human renin.
    Etoh Y, Miyazaki M, Saitoh H, Toda N.
    Jpn J Pharmacol; 1993 Sep 21; 63(1):109-19. PubMed ID: 8271523
    [Abstract] [Full Text] [Related]

  • 32. Structure-based drug design: the discovery of novel nonpeptide orally active inhibitors of human renin.
    Rahuel J, Rasetti V, Maibaum J, Rüeger H, Göschke R, Cohen NC, Stutz S, Cumin F, Fuhrer W, Wood JM, Grütter MG.
    Chem Biol; 2000 Jul 21; 7(7):493-504. PubMed ID: 10903938
    [Abstract] [Full Text] [Related]

  • 33. X-ray analysis at 2.0 A resolution of mouse submaxillary renin complexed with a decapeptide inhibitor CH-66, based on the 4-16 fragment of rat angiotensinogen.
    Dealwis CG, Frazao C, Badasso M, Cooper JB, Tickle IJ, Driessen H, Blundell TL, Murakami K, Miyazaki H, Sueiras-Diaz J.
    J Mol Biol; 1994 Feb 11; 236(1):342-60. PubMed ID: 8107115
    [Abstract] [Full Text] [Related]

  • 34. New inhibitors of renin that contain novel phosphostatine Leu-Val replacements.
    Dellaria JF, Maki RG, Stein HH, Cohen J, Whittern D, Marsh K, Hoffman DJ, Plattner JJ, Perun TJ.
    J Med Chem; 1990 Feb 11; 33(2):534-42. PubMed ID: 2105396
    [Abstract] [Full Text] [Related]

  • 35. Substrate specificity of porcine renin: P1', P1, and P3 residues of renin substrates are crucial for activity.
    Wang W, Liang TC.
    Biochemistry; 1994 Dec 06; 33(48):14636-41. PubMed ID: 7981226
    [Abstract] [Full Text] [Related]

  • 36. New renin inhibitors containing phenylalanylhistidyl-gamma-amino acid derivatives in P3 - P1' position.
    Winiecka I, Marszałek D, Goldnik A, Jaworski P, Mazurek AP.
    Acta Pol Pharm; 2014 Dec 06; 71(1):59-69. PubMed ID: 24779195
    [Abstract] [Full Text] [Related]

  • 37. Potent in vivo inhibitors of rat renin: analogues of human and rat angiotensinogen sequences containing different classes of pseudodipeptides at the scissile site.
    Sueiras-Diaz J, Jones DM, Szelke M, Leckie BJ, Beattie SR, Beattie C, Morton JJ.
    J Pept Res; 1997 Oct 06; 50(4):239-47. PubMed ID: 9352462
    [Abstract] [Full Text] [Related]

  • 38. Novel renin inhibitors containing analogues of statine retro-inverted at the C-termini: specificity at the P2 histidine site.
    Rosenberg SH, Plattner JJ, Woods KW, Stein HH, Marcotte PA, Cohen J, Perun TJ.
    J Med Chem; 1987 Jul 06; 30(7):1224-8. PubMed ID: 3298652
    [Abstract] [Full Text] [Related]

  • 39. Renin inhibitors. Design of angiotensinogen transition-state analogues containing novel. (2R,3R,4R,5S)-5-amino-3,4-dihydroxy-2-isopropyl-7-methyloctanoic acid.
    Thaisrivongs S, Pals DT, Kroll LT, Turner SR, Han FS.
    J Med Chem; 1987 Jun 06; 30(6):976-82. PubMed ID: 3295239
    [Abstract] [Full Text] [Related]

  • 40. Optimization and in vivo evaluations of a series of small, potent, and specific renin inhibitors containing a novel Leu-Val replacement.
    Dellaria JF, Maki RG, Bopp BA, Cohen J, Kleinert HD, Luly JR, Merits I, Plattner JJ, Stein HH.
    J Med Chem; 1987 Nov 06; 30(11):2137-44. PubMed ID: 3118024
    [Abstract] [Full Text] [Related]

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